Research LetterGuanidinoacetic acid increases skeletal muscle creatine stores in healthy men
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Cited by (20)
Dietary guanidinoacetic acid supplementation improves water holding capacity and lowers free amino acid concentration of fresh meat in finishing pigs fed with various dietary protein levels
2022, Animal NutritionCitation Excerpt :It was hypothesized that dietary supplementation of GAA could increase serum creatine and improve metabolic utilization of arginine (Baker, 2009; McBreairty et al., 2015). GAA supplementation raises creatine and phosphocreatine content in skeletal muscle (Ostojic et al., 2016; J.L. Li et al., 2018), and promotes cellular bioenergetic efficiency in skeletal muscle (McBreairty et al., 2015). Muscular bioenergetic efficiency is supposed to be associated with the meat quality of finishing pigs (Wang et al., 2012; Liu et al., 2015; J.L. Li et al., 2018).
Effects of guanidinoacetic acid and betaine on growth performance, energy and nitrogen metabolism, and rumen microbial protein synthesis in lambs
2022, Animal Feed Science and TechnologyCitation Excerpt :Guanidinoacetic acid (GAA) is naturally biosynthesized from arginine and glycine in the kidneys or pancreas of vertebrates and is a direct precursor of creatine (Joncquel-Chevalier Curt et al., 2015; Ostojic et al., 2017). Creatine produces phosphocreatine, which plays a vital role in energy metabolism (Ostojic, 2016; Ostojic et al., 2016). Plant-origin feeds lack creatine, which is primarily derived from animal products, such as fish meal or bone meal (Wyss and Kaddurah-Daouk, 2000).
Guanidinoacetic acid as a novel food for skeletal muscle health
2020, Journal of Functional FoodsExperimental and computational study of guanidinoacetic acid self-aggregation in aqueous solution
2017, Food ChemistryCitation Excerpt :as a feed substance for animals. As an experimental food additive in human nutrition, supplemental GAA enhances cellular bioenergetics in energy demanding tissues, such as the brain and skeletal muscle (Ostojić, Ostojić, Drid, Vraneš, & Jovanov, 2017; Ostojić, 2017; Ostojić, Drid, & Ostojić, 2016; Ostojić, Ostojić, Drid, & Vraneš, 2016). In addition, oral GAA seems to be superior to creatine in facilitating creatine levels in healthy men (Ostojić et al., 2016), with GAA being considered as a preferred alternative to creatine.
Co-administration of creatine and guanidinoacetic acid for augmented tissue bioenergetics: A novel approach?
2017, Biomedicine and PharmacotherapyCitation Excerpt :This simple reaction takes place mainly in the liver, but also in high energy-demanding tissues (e.g. brain, skeletal muscle, myocardium) [4]. GAA has been shown to effectively increase tissue levels of creatine after exogenous administration [5,6], suggesting its important role in cellular bioenergetics. Besides transported through CRT1, GAA might be also transferred into the cell via protein carriers for taurine (SLC6A6) and γ-aminobutyric acid (GAT2), and via passive diffusion through plasmalemma [7].
This study was supported by the Serbian Ministry of Education, Science and Technological Development (Grant No. 175037), and the Faculty of Sport and Physical Education, University of Novi Sad (2015 Annual Award). The authors have no conflicts of interest to declare.