Elsevier

Nutrition

Volume 31, Issue 3, March 2015, Pages 430-436
Nutrition

Review
Therapeutic value of oral supplementation with melon superoxide dismutase and wheat gliadin combination

https://doi.org/10.1016/j.nut.2014.10.006Get rights and content
Under a Creative Commons license
open access

Highlights

  • The intake of melon superoxide dismutase (SOD) combined with gliadin increases endogenous antioxidant levels.

  • SOD–gliadin supplementation acts as an auxiliary treatment to improve life quality.

  • Large-scale trials are required to reinforce the recommendation to supplement with SOD–gliadin.

Abstract

Dietary antioxidant supplementation has been popular in Western countries. Various supplements have been developed in recent years, and research has been gathered from both animal and clinical research trials. In this review, the therapeutic value of oral administration of a combination of melon superoxide dismutase (SOD) and a vegetable polymer (gliadin) is evaluated. Critical examination of the effects of SOD–gliadin supplementation is carried out, with an emphasis on its impact on oxidative stress levels and on endogenous antioxidant pathways. Overall analysis of peer-reviewed published data suggests that intake of SOD–gliadin might have advantageous health effects. These conclusions are dependent on the condition or pathology under consideration. In general, the authors, who analyzed SOD-gliadin supplementation, support the use of SOD–gliadin supplementation as a complementary treatment rather than a therapeutic treatment. To further clarify the importance of dietary SOD–gliadin administration, additional large-scale clinical trials are recommended.

Keywords

Antioxidant
Gliadin
Nutrition
Reactive oxygen species
Superoxide anion
Superoxide dismutase

Cited by (0)

Consultation and manuscript preparation was funded by Isocell Nutra, which produces and commercializes SOD–gliadin supplements (GliSODin®).