Nutrition
Volume 26, Issue 9 , Pages 902-909 , September 2010

Dietary effect of lactoferrin-enriched fermented milk on skin surface lipid and clinical improvement of acne vulgaris

  • Jungmin Kim, M.S.

      Affiliations

    • Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin-si, Gyeonggi-do, Korea
  • ,
  • Yeonjeong Ko, M.S.

      Affiliations

    • Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin-si, Gyeonggi-do, Korea
  • ,
  • Yu-Kyung Park, Ph.D.

      Affiliations

    • Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin-si, Gyeonggi-do, Korea
  • ,
  • Nack-In Kim, M.D.

      Affiliations

    • Department of Dermatology, Kyung Hee Medical Center, Seoul, Korea
  • ,
  • Woel-Kyu Ha, Ph.D.

      Affiliations

    • Pasteur Milk Co., Ltd., Gangwon-do, Korea
  • ,
  • Yunhi Cho, Ph.D.

      Affiliations

    • Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin-si, Gyeonggi-do, Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82-31-201-3817; fax: +82-31-204-8119.

Received 21 December 2009 ,Accepted 24 May 2010.

References 

  1. Leyden JJ. New understandings of the pathogenesis of acne. J Am Acad Dermatol. 1995;32:S15–S25
  2. Tan HH, Tan AW, Barkhan T, Yan XY, Zhu M. Community-based study of acne vulgaris in adolescents in Singapore. Br J Dermatol. 2007;157:547–551
  3. Kellet SC, Gawkrodger DJ. The psychological and emotional impact of acne and the effect of treatment with isotretinoin. Br J Dermatol. 1999;140:273–282
  4. Aktan S, Ozmen E, Sanli B. Anxiety, depression, and nature of acne vulgaris in adolescents. Int J Dermatol. 2000;39:354–357
  5. Gollnick HPM, Zouboulis CC, Akamatsu H, Kurokawa I, Schulte A. Pathogenesis and pathogenesis-related treatment of acne. J Dermatol. 1991;18:489–499
  6. Cunliffe WJ, Holland DB, Clark SM, Stables GI. Comedogenesis: some new aetiological, clinical and therapeutic strategies. Br J Dermatol. 2000;142:1084–1091
  7. Boelsma E, Hendriks HF, Roza L. Nutritional skin care: health effects of micronutrients and fatty acids. Am J Clin Nutr. 2001;73:853–864
  8. Smith RN, Mann NJ, Braue A, Makelainen H, Varigos GA. A low–glycemic-load diet improves symptoms in acne vulgaris patients: a randomized controlled trial. Am J Clin Nutr. 2007;86:107–115
  9. Zouboulis CC, Nestoris S, Adler YD, Orth M, Orfanos CE, Picardo M, et al. A new concept for acne therapy: a pilot study with zileuton, an oral 5-lipoxygenase inhibitor. Arch Dermatol. 2003;139:668–670
  10. Silver RH. Lactobacillus for the control of acne. J Med Soc N J. 1961;58:52–53
  11. Yalcin AS. Emerging therapeutic potential of whey proteins and peptides. Curr Pharm Des. 2006;12:1637–1643
  12. Zimecki M, Kruzel ML. Milk-derived proteins and peptides of potential therapeutic and nutritive value. J Exp Ther Oncol. 2007;6:89–106
  13. Ling JML, Schryvers AB. Perspectives on interactions between lactoferrin and bacteria. Biochem Cell Biol. 2006;84:275–281
  14. Haversen L, Ohlsson BG, Hahn-Zoric M, Hanson LA, Mattsby-Baltzer I. Lactoferrin down-regulates the LPS-induced cytokine production in monocytic cells via NF-kappa B. Cell Immunol. 2002;220:83–95
  15. Machnicki M, Zimecki M, Zagulski T. Lactoferrin regulates the release of tumor necrosis factor alpha and interleukin 6 in vivo. Int J Exp Pathol. 1993;74:433–439
  16. Crouch SP, Slater KJ, Fletcher J. Regulation of cytokine release from mononuclear cells by the iron-binding protein lactoferrin. Blood. 1992;80:235–240
  17. O'Brien SC, Lewis JB, Cunliffe WJ. The Leeds revised acne grading system. J Dermatol Treat. 1998;9:215–220
  18. Folch J, Lees M, Sloane-Stanely GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem. 1957;226:497–509
  19. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265–275
  20. Uchida Y, Hara M, Nishio H, Sidransky E, Inoue S, Otsuka F, et al. Epidermal sphingomyelins are precursors for selected stratum corneum ceramides. J Lipid Res. 2000;41:2071–2082
  21. Serizawa S, Osawa K, Togashi K, Yamamoto A, Ito M, Hamanaka S, et al. Relationship between cholesterol sulfate and intercellular cohesion of the stratum corneum: demonstration using a push–pull meter and an improved high performance thin- layer chromatographic separation system of all major stratum corneum lipids. J Invest Dermatol. 1992;99:232–236
  22. Fonollá J, López-Huertas E, Machado FJ, Molina D, Álvarez I, Mármol E, et al. Milk enriched with “healthy fatty acids” improves cardiovascular risk markers and nutritional status in human volunteers. Nutrition. 2009;25:408–414
  23. Kwon DY, Hong SM, Ahn IS, Kim YS, Shin DW, Park S. Kochujang, a Korean fermented red pepper plus soybean paste, improves glucose homeostasis in 90% pancreatectomized diabetic rats. Nutrition. 2009;25:790–799
  24. Shin K, Wakabayashi H, Yamauchi K, Teraguchi S, Tamura Y, Kurokawa M, et al. Effects of orally administered bovine lactoferrin and lactoperoxidase on influenza virus infection in mice. J Med Microbiol. 2005;54:717–723
  25. Yamamoto A, Takenouchi K, Ito M. Impaired water barrier function in acne vulgaris. Arch Dermatol Res. 1995;287:214–218
  26. Webster GF. Inflammation in acne vulgaris. J Am Acad Dermatol. 1995;33:247–253
  27. Layton AM, Henderson CA, Cunliffe WJ. A clinical evaluation of acne scarring and its incidence. Clin Exp Dermatol. 1994;19:303–308
  28. Di Felice G, Barletta B, Butteroni C, Corinti S, Tinghino R, Colombo P, et al. Use of probiotic bacteria for prevention and therapy of allergic diseases: studies in mouse model of allergic sensitization. J Clin Gastroenterol. 2008;42:S130–S132
  29. Chapat L, Chemin K, Dubois B, Bourdet-Sicard R, Kaiserlian D. Lactobacillus casei reduces CD8+ T cell–mediated skin inflammation. Eur J Immunol. 2004;34:2520–2528
  30. Ewaschuk JB, Walker JW, Diaz H, Madsen KL. Bioproduction of conjugated linoleic acid by probiotic bacteria occurs in vitro and in vivo in mice. J Nutr. 2006;136:1483–1487
  31. Yagi M, Suzuki N, Takayama T, Arisue M, Kodama T, Yoda Y, et al. Lactoferrin suppress the adipogenic differentiation of MC3T3-G2/PA6 cells. J Oral Sci. 2008;50:419–425
  32. Wakabayashi H, Kuwata H, Yamauchi K, Teraguchi S, Tamura Y. No detectable transfer of dietary lactoferrin or its functional fragments to portal blood in healthy adult rats. Biosci Biotechnol Biochem. 2004;68:853–860
  33. Teraguchi S, Wakabayashi H, Kuwata H, Yamauchi K, Tamura Y. Protection against infections by oral lactoferrin: evaluation in animal models. Biometals. 2004;17:231–234
  34. Wakabayashi H, Takakura N, Teraguchi S, Tamura Y. Lactoferrin feeding augments peritoneal macrophage activities in mice intraperitoneally injected with inactivated Candida albicans. Microbiol Immunol. 2003;47:37–43
  35. Wakabayashi H, Kurokawa M, Shin K, Teraguchi S, Tamura Y, Shiraki K. Oral lactoferrin prevents body weight loss and increases cytokine responses during herpes simplex virus type 1 infection of mice. Biosci Biotechnol Biochem. 2004;68:537–544
  36. Kuhara T, Yamauchi K, Tamura Y, Okamura H. Orally administration of lactoferrin increases NK cell activity in mice via increased production of IL-18 and type-1 IFN in the small intestine. J Interferon Cytokine Res. 2006;26:489–499
  37. Pierard GE, Pierard-Franchimont C, Marks R, Paye M, Rogiers V. EEMCO guidance for the in vivo assessment of skin greasiness. Skin Pharmacol Appl Skin Physiol. 2000;13:372–389
  38. Clarys P, Barel A. Quantitative evaluation of skin surface lipids. Clin Dermatol. 1995;13:307–321
  39. Ito A, Kitamura K, Sato K, Akamatsu H. A novel enzymatic assay for the quantification of skin surface lipids. J Int Med Res. 1996;24:69–83

 This study was supported by a research grant from Pasteur Milk Co., Ltd., and Whanee Corp.

PII: S0899-9007(10)00169-3

doi: 10.1016/j.nut.2010.05.011

Nutrition
Volume 26, Issue 9 , Pages 902-909 , September 2010