Nutrition
Volume 27, Issue 1 , Pages 65-72 , January 2011

Iron deficiency anemia: Pregnancy outcomes with or without iron supplementation

  • Ferenc Bánhidy, Ph.D.

      Affiliations

    • Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, Budapest, Hungary
  • ,
  • Nándor Ács, Ph.D.

      Affiliations

    • Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, Budapest, Hungary
  • ,
  • Erzsébet H. Puhó, Ph.D.

      Affiliations

    • Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
  • ,
  • Andrew E. Czeizel, Ph.D., Doct.Sci.

      Affiliations

    • Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
    • Corresponding Author InformationCorresponding author. Tel.: +36-1-3944-712; fax: +36-1-3944-712.

Received 13 July 2009 ,Accepted 7 December 2009.

References 

  1. Kilpatrick SJ, Laros RK. Maternal hematologic disorders. In:  Creasy RK,  Resnik R,  Iams JD editor. Maternal-fetal medicine. 5th ed. Philadelphia: Saunders; 2004;p. 975–1004
  2. Scholl TO. Maternal nutrition and preterm delivery. In:  Bendich A,  Deckelbaum RJ editor. Preventive nutrition. Totowa, NJ: Humana Press; 2005;p. 629–663
  3. Scholl TO, Hediger ML, Fischer RL, Shearer JW. Anemia vs iron deficiency: increased risk of preterm delivery in a prospective study. Am J Clin Nutr. 1992;55:985–988
  4. Garn SM, Keating MT, Falkner F. Hematologic status and pregnancy outcomes. Am J Clin Nutr. 1981;34:115–117
  5. Murphy JF, O'Riordan J, Newcombe RG, Coles EC, Pearson JF. Relation of haemoglobin levels in the first and second trimester to pregnancy outcomes. Lancet. 1986;i:992–994
  6. Klebanoff MA, Shiono PH, Shelby JV, Trachtenberg AI, Graubard BI. Anemia and spontaneous preterm birth. Am J Obstet Gynecol. 1991;164:59–63
  7. Lu ZM, Goldenberg RL, Cliver SP, Cutter G, Blankson M. The relationship between maternal hematocrit and pregnancy outcomes. Obstet Gynecol. 1991;77:190–194
  8. Goldenberg RJ, Tamura T, DuBard M, Johnston KE, Copper RL, Neggers Y. Plasma ferritin and pregnancy outcome. Am J Obstet Gynecol. 1996;175:1356–1359
  9. Scanlon KS, Yip R, Schieve LA, Cogswell ME. High and low hemoglobin levels during pregnancy. Differential risks for preterm birth and small for gestational age. Obstet Gynecol. 2000;96:741–748
  10. Bondevik GT, Lie RT, Ulstein M, Kvale G. Maternal hematological status and risk of low birth weight and preterm delivery in Nepal. Acta Obstet Gynaecol Scand. 2001;80:402–408
  11. Sagen N, Nilsen ST, Kim HC, Bergsjo P, Koller O. Maternal hemoglobin concentration is closely related to birth weight in normal pregnancy. Acta Obstet Gynecol. 1984;63:245–250
  12. Steer P, Alam MA, Wadsworth J, Welch A. Relation between hemoglobin concentration and birth weight in different ethnic groups. BMJ. 1995;310:489–491
  13. Allen LH. Anemia and iron deficiency: Effects on pregnancy outcomes. Am J Clin Nutr. 2000;71:1280S–1284S
  14. Yip R. Significance of an abnormally low or high hemoglobin concentration during pregnancy. Special consideration of iron nutrition. Am J Clin Nutr. 2000;72:272S–279S
  15. Rasmussen KM. Is there a causal relationship between iron deficiency or iron deficiency anemia and weight at birth, length of gestation, and perinatal mortality?. J Nutr. 2001;131:590S–603S
  16. Brabin BJ, Hakimi M, Pelletier D. An analysis of anemia and pregnancy-related maternal mortality. J Nutr. 2001;131:604S–615S
  17. Czeizel AE, Rockenbauer M, Siffel CS, Varga E. Description and mission evaluation of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980–1996. Teratology. 2001;63:176–185
  18. Czeizel AE. The first 25 years of the Hungarian Congenital Abnormality Registry. Teratology. 1997;55:299–305
  19. Czeizel AE, Intõdy ZS, Modell B. What proportion of congenital abnormalities can be prevented?. BMJ. 1993;306:499–503
  20. Czeizel AE, Petik D, Vargha P. Validation studies of drug exposures in pregnant women. Pharmacoepidemiology Drug Safety. 2003;12:409–416
  21. Czeizel AE, Vargha P. Periconceptional folic acid/multivitamin supplementation and twin pregnancy. Am J Obstet Gynecol. 2004;191:790–794
  22. In:  Laros RK editors. Blood disorders in pregnancy. Philadelphia: Lea and Febiger; 1986;
  23. Alper BS, Kimber R, Reddy AK. Using ferritin levels to determine iron deficiency anemia in pregnancy. J Fam Practice. 2000;49:829–834
  24. CDC . Centers for Disease Control and Prevention: Recommendation to prevent and control iron deficiency anemia in the Unites States. MMWR (Morb Mortal Wkly Rep). 1988;47:1–11
  25. Czeizel AE, Puho HE, Ács N, Bánhidy F. Use of specified critical periods of different congenital abnormalities instead of the first trimester concept. Birth Defects Res (Part A). 2008;82:139–146
  26. Puho HE, Métneki J, Czeizel AE. Maternal employment status and isolated orofacial clefts in Hungary. Cent Eur J Publ Health. 2004;13:144–148
  27. Scott DE, Pritchard JA. Iron deficiency in healthy young college women. JAMA. 1967;199:897–900
  28. Pritchard JA, Whalley PJ, Scott DE. The influence of maternal folate and iron deficiency on intrauterine life. Am J Obstet Gynecol. 1969;104:388–392
  29. Stephansson O, Dickman PW, Johansson A, Cnattingius S. Maternal hemoglobin concentration during pregnancy and risk of stillbirth. JAMA. 2000;284:2611–2617
  30. Allen LH. Biological mechanism that might underline iron's effects on fetal growth and preterm birth. J Nutr. 2001;131:581–589
  31. Scholl TO, Hediger ML. Anemia and iron-deficiency anemia: Compilation of data on pregnancy outcome. Am J Clin Nutr. 1994;59(suppl):492S–501S
  32. Xiong X, Buekens P, Alexander S, Demianczuk N, Wollast E. Anemia during pregnancy and birth outcomes: a meta-analysis. Am J Perinatol. 2000;17:137–141
  33. Williamson C. Gastrointestinal disease. Best Pract Res Clin Obstet and Gynaecol. 2001;15(No. 5):937–952
  34. Welsh A. Hyperemesis, gastrointestinal and liver disorders in pregnancy. Curr Obstet Gynaecol. 2005;15:123–131
  35. Czeizel AE, Dudás I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med. 1992;327:1832–1835
  36. Czeizel AE, Dobo M, Vargha P. Hungarian cohort-controlled trial of periconceptional multivitamin supplementation shows reduction in certain congenital abnormalities. Birth Defects Res (Part A). 2004;70:853–861
  37. Czeizel AE. Periconceptional folic acid/multivitamin supplementation and the prevention of NTD and other congenital abnormalities. Birth Defects Res (Part A). 2009;85:260–268
  38. Czeizel AE, Puho E. Maternal use of nutritional supplements during the first month of pregnancy and a reduced risk of Down's syndrome. A case-control study. Nutrition. 2005;21:698–704
  39. Czeizel AE, Petik D, Puho AE. Smoking and alcohol drinking during pregnancy. The reliability of retrospective maternal self-reported information. Cent Eur J Publ Health. 2004;12:179–183
  40. Czeizel AE, Kodaj I, Lenz WC. Smoking during pregnancy and congenital limb deficiency. BMJ. 1994;308:1473–1476

PII: S0899-9007(10)00003-1

doi: 10.1016/j.nut.2009.12.005

Nutrition
Volume 27, Issue 1 , Pages 65-72 , January 2011