Nutrition
Volume 26, Issue 11 , Pages 1176-1180 , November 2010

Mitochondrial HMG-CoA synthase partially contributes to antioxidant protection in the kidney of stroke-prone spontaneously hypertensive rats

  • Weijie Yi, M.D.

      Affiliations

    • Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
  • ,
  • Ping Fu, M.D.

      Affiliations

    • Tongji Medical College Hospital, Huazhong University of Science and Technology, Wuhan, People's Republic of China
  • ,
  • Zhiliang Fan, M.D.

      Affiliations

    • Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
  • ,
  • Hiroaki Aso, Ph.D.

      Affiliations

    • Department of Biological Pharmacy, School of Pharmacy, Shujitsu University, Okayama, Japan
  • ,
  • Chong Tian, M.D.

      Affiliations

    • Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
  • ,
  • Yi Meng, M.D.

      Affiliations

    • Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
  • ,
  • Jian Liu, Ph.D., M.D.

      Affiliations

    • Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
  • ,
  • Yukio Yamori, Ph.D., M.D.

      Affiliations

    • Institute for World Health Development, Mukogawa Women's University, Nishinomiya, Japan
  • ,
  • Yasuo Nara, Ph.D.

      Affiliations

    • Department of Biological Pharmacy, School of Pharmacy, Shujitsu University, Okayama, Japan
  • ,
  • Chenjiang Ying, Ph.D., M.D.

      Affiliations

    • Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
    • Corresponding Author InformationCorresponding author. Tel.: +86-027-8369-2711; fax: +86-027-8369-3307.

Received 11 June 2009 ,Accepted 21 October 2009.

References 

  1. Huttenlocher PR. Ketonemia and seizures: metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res. 1976;10:536–540
  2. Likhodii SS, Serbanescu I, Cortez MA, Murphy P, Snead OC, Burnham WM. Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet. Ann Neurol. 2003;54:219–226
  3. Denny CA, Kasperzyk JL, Gorham KN, Bronson RT, Seyfried TN. Influence of caloric restriction on motor behavior, longevity, and brain lipid composition in Sandhoff disease mice. J Neurosci Res. 2006;83:1028–1038
  4. Stafstrom CE. Animal models of the ketogenic diet: what have we learned, what can we learn?. Epilepsy Res. 1999;37:241–259
  5. Kashiwaya Y, Takeshima T, Mori N, Nakashima K, Clarke K, Veech RL. D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease. Proc Natl Acad Sci U S A. 2000;97:5440–5444
  6. Dardzinski BJ, Smith SL, Towfighi J, Williams GD, Vannucci RC, Smith MB. Increased plasma beta-hydroxybutyrate, preserved cerebral energy metabolism, and amelioration of brain damage during neonatal hypoxia ischemia with dexamethasone pretreatment. Pediatr Res. 2000;48:248–255
  7. Girard J, Ferre P, Pegorier JP, Duee PH. Adaptations of glucose and fatty acid metabolism during perinatal period and suckling-weaning transition. Physiol Rev. 1992;72:507–562
  8. McGarry JD, Foster DW. Regulation of hepatic fatty acid oxidation and ketone body production. Annu Rev Biochem. 1980;49:395–420
  9. Quant PA. Activity and expression of hepatic mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase during the starved-to-fed transition. Biochem Soc Trans. 1990;18:994–995
  10. Juge-Aubry C, Pernin A, Favez T, Burger AG, Wahli W, Meier CA, et al. DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5′-flanking region. J Biol Chem. 1997;272:25252–25259
  11. Stachowska E, Baskiewicz-Masiuk M, Dziedziejko V, Gutowska I, Baranowska-Bosiacka I, Marchlewicz M, et al. Conjugated linoleic acid increases intracellular ROS synthesis and oxygenation of arachidonic acid in macrophages. Nutrition. 2008;24:187–199
  12. Nadal A, Marrero PF, Haro D. Down-regulation of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by insulin: the role of the forkhead transcription factor FKHRL1. Biochem J. 2002;366:289–297
  13. Rojo AI, Salinas M, Martín D, Perona R, Cuadrado A. Regulation of Cu/Zn-superoxide dismutase expression via the phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-kappaB. J Neurosci. 2004;24:7324–7334
  14. Nogueira V, Park Y, Chen CC, Xu PZ, Chen ML, Tonic I, et al. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell. 2008;14:458–470
  15. Fornage M, Swank MW, Boerwinkle E, Doris PA. Gene expression profiling and functional proteomic analysis reveal perturbed kinase-mediated signaling in genetic stroke susceptibility. Physiol Genomics. 2003;15:75–83
  16. Okamoto K, Yamori Y, Nagaoka A. Establishment of the stroke-prone spontaneously hypertensive rat (SHR). Circ Res. 1974;34–35(Suppl I):I-143–I-153
  17. Kerr S, Brosnan MJ, McIntyre M, Reid JL, Dominiczak AF, Hamilton CA. Superoxide anion production is increased in a model of genetic hypertension. Hypertension. 1999;33:1353–1358
  18. Ying CJ, Noguchi T, Aso H, Ikeda K, Yamori Y, Nara Y. The role of cytochrome p-450 in salt-sensitive stroke in stroke-prone spontaneously hypertensive rats. Hypertens Res. 2008;31:1821–1827
  19. Physiological Society of Japan . Guiding principles for the care and use of animals in the field of physiological sciences. J Physiol Soc Jpn. 1998;60:vii–viii
  20. Krapfenbauer K, Berger M, Lubec G, Fountoulakis M. Changes in the brain protein levels following administration of kainic acid. Electrophoresis. 2001;22:2086–2091
  21. Ying CJ, Xu JW, Ikeda K, Takahashi K, Nara Y, Yamori Y. Tea polyphenols regulate nicotinamide adenine dinucleotide phosphate oxidase subunit expression and ameliorate angiotensin II–induced hyperpermeability in endothelial cells. Hypertens Res. 2003;26:823–828
  22. Yuan GJ, Ma JC, Gong ZJ, Sun XM, Zheng SH, Li X. Modulation of liver oxidant-antioxidant system by ischemic preconditioning during ischemia/reperfusion injury in rats. World J Gastroenterol. 2005;11:1825–1828
  23. Kishi T, Hirooka Y, Kimura Y, Ito K, Shimokawa H, Takeshita A. Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats. Circulation. 2004;109:2357–2362
  24. Tanito M, Nakamura H, Kwon YW, Teratani A, Masutani H, Shioji K, et al. Enhanced oxidative stress and impaired thioredoxin expression in spontaneously hypertensive rats. Antioxid Redox Signal. 2004;6:89–97
  25. Yamamoto M, Suzuki A, Jokura H, Yamamoto N, Hase T. Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats. Nutrition. 2008;24:470–476
  26. Valera A, Pelegrin M, Asins G, Fillat C, Sabater J, Pujol A, et al. Overexpression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in transgenic mice causes hepatic hyperketogenesis. J Biol Chem. 1994;269:6267–6270
  27. Kim Do Y, Davis LM, Sullivan PG, Maalouf M, Simeone TA, van Brederode J, et al. Ketone bodies are protective against oxidative stress in neocortical neurons. J Neurochem. 2007;101:1316–1326
  28. Maalouf M, Sullivan PG, Davis L, Kim DY, Rho JM. Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation. Neuroscience. 2007;145:256–264
  29. Rodriguez JC, Gil-Gomez G, Hegardt FG, Haro D. Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids. J Biol Chem. 1994;269:18767–18772
  30. Rajaraman G, Wang GQ, Yan J, Jiang P, Gong Y, Burczynski FJ. Role of cytosolic liver fatty acid binding protein in hepatocellular oxidative stress: effect of dexamethasone and clofibrate treatment. Mol Cell Biochem. 2007;295:27–34
  31. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell. 2005;120:513–522
  32. Brownawell AM, Kops GJ, Macara IG, Burgering BM. Inhibition of nuclear import by protein kinase b (akt) regulates the subcellular distribution and activity of the forkhead transcription factor afx. Mol Cell Biol. 2001;21:3534–3546
  33. Kops GJ, de Ruiter ND, De Vries-Smits AM, Powell DR, Bos JL, Burgering BM. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature. 1999;398:630–634
  34. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 1999;96:857–868
  35. Li R, Zheng W, Pi R, Gao J, Zhang H, Wang P, et al. Activation of peroxisome proliferator-activated receptor-alpha prevents glycogen. FEBS Lett. 2007;581:3311–3316
  36. Grabacka M, Plonka PM, Urbanska K, Reiss K. Peroxisome proliferator-activated receptor alpha activation decreases metastatic potential of melanoma cells in vitro via down-regulation of Akt. Clin Cancer Res. 2006;12:3028–3036

 This work was supported in part by the Japan-China Sasagawa Medical Fellowship and by grant 30471461 (C. Ying) from the National Natural Science Foundation of China.

PII: S0899-9007(09)00434-1

doi: 10.1016/j.nut.2009.10.010

Nutrition
Volume 26, Issue 11 , Pages 1176-1180 , November 2010