Nutrition
Volume 26, Issue 7 , Pages 811-817 , July 2010

Effects of different ratios of monounsaturated and polyunsaturated fatty acids to saturated fatty acids on regulating body fat deposition in hamsters

  • Fang-Hsuean Liao, M.S.

      Affiliations

    • School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan, Republic of China
  • ,
  • Tsan-Hon Liou, M.D., Ph.D.

      Affiliations

    • Obesity Research Center and Department of Physical Medicine and Rehabilitation, Taipei Medical University–Shuang Ho Hospital, Taipei, Taiwan; Graduate Institute of Injury Prevention, Taipei Medical University, Taipei, Taiwan, Republic of China
  • ,
  • Ming-Jer Shieh, Ph.D.

      Affiliations

    • School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan, Republic of China
  • ,
  • Yi-Wen Chien, Ph.D.

      Affiliations

    • School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan, Republic of China
    • Corresponding Author InformationCorresponding author. Tel.: +886-2-2736-1661, ext. 6556; fax: +886-2-2737-3112.

Received 24 October 2008 ,Accepted 13 September 2009.

References 

  1. Bray GA, Popkin BM. Dietary fat intake does affect obesity!. Am J Clin Nutr. 1998;68:1157–1173
  2. James WP, Rigby N, Leach R. Obesity and the metabolic syndrome: the stress on society. Ann N Y Acad Sci. 2006;1083:1–10
  3. Hill JO, Peters JC, Lin D, Yakubu F, Greene H, Swift L. Lipid accumulation and body fat distribution is influenced by type of dietary fat fed to rats. Int J Obes Relat Metab Disord. 1993;17:223–236
  4. Ikemoto S, Takahashi M, Tsunoda N, Maruyama K, Itakura H, Ezaki O. High-fat diet-induced hyperglycemia and obesity in mice: differential effects of dietary oils. Metabolism. 1996;45:1539–1546
  5. Dulloo AG, Mensi N, Seydoux J, Girardier L. Differential effects of high-fat diets varying in fatty acid composition on the efficiency of lean and fat tissue deposition during weight recovery after low food intake. Metabolism. 1995;44:273–279
  6. Nagao K, Yanagita T. Bioactive lipids in metabolic syndrome. Prog Lipid Res. 2008;47:127–146
  7. Jones PJ, Ridgen JE, Phang PT, Birmingham CL. Influence of dietary fat polyunsaturated to saturated ratio on energy substrate utilization in obesity. Metabolism. 1992;41:396–401
  8. Clandinin MT, Wang LC, Rajotte RV, French MA, Goh YK, Kielo ES. Increasing the dietary polyunsaturated fat content alters whole-body utilization of 16:0 and 10:0. Am J Clin Nutr. 1995;61:1052–1057
  9. Buettner R, Parhofer KG, Woenckhaus M, Wrede CE, Kunz-Schughart LA, Schölmerich J, et al. Defining high-fat-diet rat models: metabolic and molecular effects of different fat types. J Mol Endocrinol. 2006;36:485–501
  10. Takeuchi H, Nakamoto T, Mori Y, Kawakami M, Mabuchi H, Ohishi Y, et al. Comparative effects of dietary fat types on hepatic enzyme activities related to the synthesis and oxidation of fatty acid and to lipogenesis in rats. Biosci Biotechnol Biochem. 2001;65:1748–1754
  11. Bes-Rastrollo M, Sanchez-Villegas A, de la Fuente C, de Irala J, Martinez JA, Martinez-Gonzalez MA. Olive oil consumption and weight change: the SUN prospective cohort study. Lipids. 2006;41:249–256
  12. Clifton PM, Noakes M, Keogh JB. Very low-fat (12%) and high monounsaturated fat (35%) diets do not differentially affect abdominal fat loss in overweight, nondiabetic women. J Nutr. 2004;134:1741–1745
  13. Jones PJ, Pencharz PB, Clandinin MT. Whole body oxidation of dietary fatty acids: implications for energy utilization. Am J Clin Nutr. 1985;42:769–777
  14. Fernandez ML, West KL. Mechanisms by which dietary fatty acids modulate plasma lipids. J Nutr. 2005;135:2075–2078
  15. Shimomura I, Bashmakov Y, Ikemoto S, Horton JD, Brown MS, Goldstein JL. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. Proc Natl Acad Sci U S A. 1999;96:13656–13661
  16. Field FJ, Born E, Mathur SN. Fatty acid flux suppresses fatty acid synthesis in hamster intestine independently of SREBP-1 expression. J Lipid Res. 2003;44:1199–1208
  17. Xu J, Nakamura MT, Cho HP, Clarke SD. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats. J Biol Chem. 1999;274:23577–23583
  18. Jump DB, Botolin D, Wang Y, Xu J, Christian B, Demeure O. Fatty acid regulation of hepatic gene transcription. J Nutr. 2005;135:2503–2506
  19. Schoonjans K, Staels B, Auwerx J. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res. 1996;37:907–925
  20. Duplus E, Glorian M, Forest C. Fatty acid regulation of gene transcription. J Biol Chem. 2000;275:30749–30752
  21. Lee JH, Fukumoto M, Nishida H, Ikeda I, Sugano M. The interrelated effects of n-6/n-3 and polyunsaturated/saturated ratios of dietary fats on the regulation of lipid metabolism in rats. J Nutr. 1989;119:1893–1899
  22. Lu YF, Wu HL. Effect of monounsaturated fatty acids under fixed P/S and n-6/n-3 ratios on lipid metabolism in rats. J Nutr Sci Vitaminol (Tokyo). 1994;40:189–200
  23. Chang NW, Huang PC. Comparative effects of polyunsaturated- to saturated fatty acid ratio versus polyunsaturated- and monounsaturated fatty acids to saturated fatty acid ratio on lipid metabolism in rats. Atherosclerosis. 1999;142:185–191
  24. Kang MJ, Shin MS, Park JN, Lee SS. The effects of polyunsaturated:saturated fatty acids ratios and peroxidisability index values of dietary fats on serum lipid profiles and hepatic enzyme activities in rats. Br J Nutr. 2005;94:526–532
  25. Arbeeny CM, Meyers DS, Bergquist KE, Gregg RE. Inhibition of fatty acid synthesis decreases very low density lipoprotein secretion in the hamster. J Lipid Res. 1992;33:843–851
  26. Wade GN. Obesity without overeating in golden hamsters. Physiol Behav. 1982;29:701–707
  27. Reeves PG, Nielsen FH, Fahey GC. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition Ad Hoc Writing Committee on the reformulation of the AIN-76 rodent diet. J Nutr. 1993;123:1939–1951
  28. Morisson W, Smith L. Preparation of fatty acid methyl esters and dimetylacetals from lipids with boron fluoride methanol. J Lipid Res. 1964;5:600–608
  29. National Science Council. Guide for the care and use of laboratory animals. Taipei, Taiwan: ROC: National Science Council; 1994;
  30. Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem. 1957;226:497–509
  31. Kelley DS, Nelson GJ, Hunt JE. Effect of prior nutritional status on the activity of lipogenic enzymes in primary monolayer cultures of rat hepatocytes. Biochem J. 1986;235:87–90
  32. Numa S, Ringelmann E, Lynen F. On inhibition of acetyl-CoA-carboxylase by fatty acid–coenzyme A compounds. Biochem Z. 1965;343:243–257
  33. Small GM, Burdett K, Connock MJ. A sensitive spectrophotometric assay for peroxisomal acyl-CoA oxidase. Biochem J. 1985;227:205–210
  34. Hsu RY, Lardy HA. Pigeon liver malic enzyme. II. Isolation, crystallization, and some properties. J Biol Chem. 1967;242:520–526
  35. Bieber LL, Abraham T, Helmrath T. A rapid spectrophotometric assay for carnitine palmitoyltransferase. Anal Biochem. 1972;50:509
  36. Zabala A, Churruca I, Fernández-Quintela A, Rodríguez VM, Macarulla MT, Martínez JA, et al. Trans-10, cis-12 conjugated linoleic acid inhibits lipoprotein lipase but increases the activity of lipogenic enzymes in adipose tissue from hamsters fed an atherogenic diet. Br J Nutr. 2006;95:1112–1119
  37. Kien CL, Bunn JY, Ugrasbul F. Increasing dietary palmitic acid decreases fat oxidation and daily energy expenditure. Am J Clin Nutr. 2005;82:320–326
  38. Bueno AA, Oyama LM, de Oliveira C, Pisani LP, Ribeiro EB, Silveira VL. Oller do Nascimento CM. Effects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissue. Pflugers Arch. 2008;455:701–709
  39. Okada T, Furuhashi N, Kuromori Y, Miyashita M, Iwata F, Harada K. Plasma palmitoleic acid content and obesity in children. Am J Clin Nutr. 2005;82:747–750
  40. Lee JS, Pinnamaneni SK, Eo SJ, Cho IH, Pyo JH, Kim CK, et al. Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites. J Appl Physiol. 2006;100:1467–1474
  41. Wilding JP. The importance of free fatty acids in the development of type 2 diabetes. Diabet Med. 2007;24:934–945
  42. Frayn KN, Williams CM, Arner P. Are increased plasma non-esterified fatty acid concentrations a risk marker for coronary heart disease and other chronic diseases?. Clin Sci. 1996;90:243–253
  43. Takeuchi H, Matsuo T, Tokuyama K, Shimomura Y, Suzuki M. Diet-induced thermogenesis is lower in rats fed a lard diet than in those fed a high oleic acid safflower oil diet, a safflower oil diet or a linseed oil diet. J Nutr. 1995;125:920–925
  44. Schröder H. Protective mechanisms of the Mediterranean diet in obesity and type 2 diabetes. J Nutr Biochem. 2007;18:149–160
  45. Rodríguez VM, Portillo MP, Picó C, Macarulla MT, Palou A. Olive oil feeding up-regulates uncoupling protein genes in rat brown adipose tissue and skeletal muscle. Am J Clin Nutr. 2002;75:213–220
  46. Palou A, Picó C, Bonet ML, Oliver P. Molecules in focus: the uncoupling protein thermogenin. Int J Biochem Cell Biol. 1998;30:7–11
  47. Kelly LJ, Vicario PP, Thompson GM, Candelore MR, Doebber TW, Ventre J, et al. Peroxisome proliferator-activated receptors gamma and alpha mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression. Endocrinology. 1998;139:4920–4927
  48. Soriguer F, Moreno F, Rojo-Martínez G, García-Fuentes E, Tinahones F, Gómez-Zumaquero JM, et al. Monounsaturated n-9 fatty acids and adipocyte lipolysis in rats. Br J Nutr. 2003;90:1015–1022
  49. Madsen L, Petersen RK, Kristiansen K. Regulation of adipocyte differentiation and function by polyunsaturated fatty acids. Biochim Biophys Acta. 2005;1740:266–286
  50. Ren B, Thelen AP, Peters JM, Gonzalez FJ, Jump DB. Polyunsaturated fatty acid suppression of hepatic fatty acid synthase and S14 gene expression does not require peroxisome proliferator-activated receptor alpha. J Biol Chem. 1997;272:26827–26832
  51. Banner CD, Gottlicher M, Widmark E, Sjovall J, Rafter JJ, Gustafsson JA. A systematic analytical chemistry/cell assay approach to isolate activators of orphan nuclear receptors from biological extracts: characterization of peroxisome proliferator-activated receptor activators in plasma. J Lipid Res. 1993;34:1583–1591

 This study was supported by a grant from the National Science Council of Taiwan (NSC95-2320-B-038-039).

PII: S0899-9007(09)00401-8

doi: 10.1016/j.nut.2009.09.009

Nutrition
Volume 26, Issue 7 , Pages 811-817 , July 2010