Nutrition
Volume 26, Issue 7 , Pages 823-828 , July 2010

Effect of whole walnuts and walnut-skin extracts on oxidant status in mice

  • Mónica Bulló, Ph.D.

      Affiliations

    • Human Nutrition Unit, Department of Biochemistry and Biotechnology, Facultat de Medicinia i Ciències de la Salut, ISPV, Universitat Rovira i Virgili, Reus, Spain
    • CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Santiago de Compostela, Spain
    • Corresponding Author InformationCorresponding author. Tel.: +34-977-75-93-12; fax: +34-977-75-93-22.
    • ,
  • M. Rosa Nogués, Ph.D.

      Affiliations

    • Unit of Pharmacology, Facultat de Medicinia i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain
    • ,
  • Patricia López-Uriarte, B.Sc.

      Affiliations

    • Human Nutrition Unit, Department of Biochemistry and Biotechnology, Facultat de Medicinia i Ciències de la Salut, ISPV, Universitat Rovira i Virgili, Reus, Spain
    • ,
  • Jordi Salas-Salvadó, Ph.D.

      Affiliations

    • Human Nutrition Unit, Department of Biochemistry and Biotechnology, Facultat de Medicinia i Ciències de la Salut, ISPV, Universitat Rovira i Virgili, Reus, Spain
    • CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Santiago de Compostela, Spain
    • Nutrition and Dietetics Unit, Internal Medicine Department, Hospital Universitari de Sant Joan, Reus, Spain
    • ,
  • Marta Romeu, Ph.D.

      Affiliations

    • Unit of Pharmacology, Facultat de Medicinia i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain

Received 4 February 2009 ,Accepted 2 September 2009.

References 

  1. Goldstein JL, Ho YK, Basu SK, Brown MS. Binding site on macrophages that mediates uptake and degradation of acetylated density lipoprotein, producing massive cholesterol deposition. Proc Nat Acad Sci U S A. 1979;76:333–337
  2. Willcox BJ, Curb JD, Rodriguez BL. Antioxidants in cardiovascular health and disease: key lessons from epidemiologic studies. Am J Cardiol. 2008;101(suppl 10A):75D–86D
  3. Spranger T, Finckh B, Fingerhut R, Kohlschütter A, Beisiegel U, Kontush A. How different constituents of human plasma and low density lipoprotein determine plasma oxidizability by copper. Chem Phys Lipids. 1998;91:39–52
  4. Hissin PJ, Hilf R. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem. 1976;74:214–226
  5. Cao G, Alessio HM, Cutler RG. Oxygen-radical absorbance capacity assay for antioxidants. Free Radic Biol Med. 1993;14:303–311
  6. Ou B, Hampsch-Woodill M, Prior RL. Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe. J Agric Food Chem. 2001;49:4619–4626
  7. Wu X, Gu L, Holden J, Haytowitz DB, Gebhardt SE, Beecher G, et al. Development of a database for total antioxidant capacity in foods: a preliminary study. J Food Comp Anal. 2004;17:407–422
  8. Benzie IFF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Ann Biochem. 1996;239:70–76
  9. Richard D, Kefi K, Barbe U, Bausero P, Visioli F. Polyunsaturated fatty acids as antioxidants. Pharmacol Res. 2008;57:451–455
  10. Ros E, Mataix J. Fatty acid composition of nuts-implications for cardiovascular health. Br J Nutr. 2006;96(suppl 2):S29–S35
  11. Reiter RJ, Manchester LC, Tan DX. Melatonin in walnuts: Influence on levels of melatonin and total antioxidant capacity of blood. Nutrition. 2005;21:920–924
  12. Chen CY, Milbury PE, Lapsley K, Blumberg JB. Flavonoids from almond skins are bioavailable and act synergistically with vitamins C and E to enhance hamster and human LDL resistance to oxidation. J Nutr. 2005;135:1366–1373
  13. Jia X, Li N, Zhang W, Zhang X, Lapsley K, Huang G, et al. A pilot study on the effects of almond consumption on DNA damage and oxidative stress in smokers. Nutr Cancer. 2006;54:179–183
  14. Jenkins DJ, Kendall CW, Marchie A, Josse AR, Nguyen TH, Faulkner DA, et al. Almonds reduce biomarkers of lipid peroxidation in older hyperlipidemic subjects. J Nutr. 2008;138:908–913
  15. Muñoz S, Merlos M, Zambón D, Rodríguez C, Sabaté J, Ros E, et al. Walnut-enriched diet increases the association of LDL from hypercholesterolemic men with human HepG2 cells. J Lipid Res. 2001;42:2069–2076
  16. Iwamoto M, Imaizumi K, Sato M, Hirooka Y, Sakai K, Takeshita A, et al. Serum lipid profiles in Japanese women and men during consumption of walnuts. Eur J Clin Nutr. 2002;56:629–637
  17. Davis L, Stonehouse W, Loots du T, Mukuddem-Petersen J, van der Westhuizen FH, Hanekom SM, et al. The effects of high walnut and cashew nut diets on the antioxidant status of subjects with metabolic syndrome. Eur J Nutr. 2007;46:155–164
  18. Reaven P, Parthasarathy S, Grasse BJ, Miller E, Almazan F, Mattson FH, et al. Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans. Am J Clin Nutr. 1991;54:701–706
  19. Bonanome A, Pagnan A, Biffanti S, Opportuno A, Sorgato F, Dorella M, et al. Effect of dietary monounsaturated and polyunsaturated fatty acids on the susceptibility of plasma low density lipoproteins to oxidative modification. Arterioscler Thromb. 1992;12:529–533
  20. Mata P, Alonso R, Lopez-Farre A, Ordovas JM, Lahoz C, Garces C, et al. Effect of dietary fat saturation on LDL oxidation and monocyte adhesion to human endothelial cells in vitro. Arterioscler Thromb Vasc Biol. 1996;16:1347–1355
  21. Hargrove RL, Etherton TD, Pearson TA, Harrison EH, Kris-Etherton PM. Low fat and high monounsaturated fat diets decrease human low density lipoprotein oxidative susceptibility in vitro. J Nutr. 2001;131:1758–1763
  22. Parthasarathy S, Khoo JC, Miller E, Barnett J, Witztum JL, Steinberg D. Low density lipoprotein rich in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis. Proc Nat Acad Sci U S A. 1990;87:3894–3898
  23. Zambón D, Sabaté J, Muñoz S, Campero B, Casals E, Merlos M, et al. Substituting walnuts for monounsaturated fat improves the serum lipid profile of hypercholesterolemic men and women. A randomized crossover trial. Ann Intern Med. 2000;132:538–546
  24. Ros E, Núñez I, Pérz-Heras A, Serra M, Gilabert R, Casals E, et al. A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. Circulation. 2004;109:1609–1614
  25. Wilson T, Knight TJ, Beitz DC, Lewis DS, Engen RL. Resveratrol promotes atherosclerosis in hypercholesterolemic rabbits. Life Sci. 1996;59:PL15–PL21
  26. Auger C, Gérain P, Laurent-Bichon F, Portet K, Bornet A, Caporiccio B, et al. Phenolics from commercialized grape extracts prevent early atherosclerotic lesions in hamsters by mechanisms other than antioxidant effect. J Agric Food Chem. 2004;52:5297–5302
  27. Acín S, Navarro MA, Arbonés-Mainar JM, Guillén N, Sarría AJ, Carnicer R, et al. Hydroxytyrosol administration enhances atherosclerotic lesion development in apo E deficient mice. J Biochem. 2006;140:383–391
  28. Shimoi K, Yoshizumi K, Kido T, Usui Y, Yumoto T. Absorption and urinary excretion of quercetin, rutin, and alphaG-rutin, a water soluble flavonoid, in rats. J Agric Food Chem. 2003;51:2785–2789
  29. Lesser S, Cermak R, Wolffram S. Bioavailability of quercetin in pigs is influenced by the dietary fat content. J Nutr. 2004;134:1508–1511

 Patricia López-Uriarte is the recipient of a predoctoral fellowship from the Catalan government's Department of Universities, Research, and the Information Society.

PII: S0899-9007(09)00371-2

doi: 10.1016/j.nut.2009.09.002

Nutrition
Volume 26, Issue 7 , Pages 823-828 , July 2010

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