Nutrition
Volume 26, Issue 7 , Pages 818-822 , July 2010

Effects of different arginine concentrations on angiogenic protein production induced by HeLa cells

  • Szu-Yuan Chou, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei Medical University–Associated Wan Fang Hospital, Taipei, Taiwan
  • ,
  • Chun-Sen Hsu, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei Medical University–Associated Wan Fang Hospital, Taipei, Taiwan
    • Corresponding Author InformationCorresponding author. C.-S. Hsu: Tel.: 8862-2930-7930, ext. 2501; S.-L. Yeh: Tel.: +8862-2736-1661, ext. 6547; fax: +8862-2737-3112.
  • ,
  • Ming-Yi Hsu, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei Medical University–Associated Wan Fang Hospital, Taipei, Taiwan
  • ,
  • So-Jung Liang, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei Medical University–Associated Wan Fang Hospital, Taipei, Taiwan
  • ,
  • Chiu-Li Yeh, Ph.D.

      Affiliations

    • Institute of Nutrition and Health Sciences, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan
  • ,
  • Sung-Ling Yeh, Ph.D.

      Affiliations

    • School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan
    • Corresponding Author InformationCorresponding author. C.-S. Hsu: Tel.: 8862-2930-7930, ext. 2501; S.-L. Yeh: Tel.: +8862-2736-1661, ext. 6547; fax: +8862-2737-3112.

Received 6 February 2009 ,Accepted 9 August 2009.

References 

  1. de Jonge WJ, Marescau B, D'Hooge R, De Deyn PP, Hallemeesch MM, Deutz NE, et al. Overexpression of arginase alters circulating and tissue amino acids and guanidino compounds and affects neuromotor behavior in mice. J Nutr. 2001;131:2732–2740
  2. Barbul A, Lazarou SA, Efron DT, Wasserkrug HL, Efron G. Arginine enhances wound healing and lymphocyte immune responses in humans. Surgery. 1990;108:331–336
  3. Yeh CL, Lee CH, Chen SC, Hou YC, Yeh SL. Effects of arginine-containing total parenteral nutrition on N balance and phagocytic activity in rats undergoing a partial gastrectomy. Br J Nutr. 2005;93:267–272
  4. Gianotti L, Alexander JW, Pyles T, Fukushima R. Arginine-supplemented diets improve survival in gut-derived sepsis and peritonitis by modulating bacterial clearance. The role of nitric oxide. Ann Surg. 1993;217:644–653
  5. Evoy D, Lieberman MD, Fahey TJ, Daly JM. Immunonutrition: the role of arginine. Nutrition. 1998;14:611–617
  6. De-Souza DA, Greene LJ. Pharmacological nutrition after burn injury. J Nutr. 1998;128:797–803
  7. Kirk SJ, Regan MC, Wasserkrug HL, Sodeyama M, Barbul A. Arginine enhances T-cell responses in athymic nude mice. JPEN. 1992;16:429–432
  8. Ochoa JB, Bernard AC, Mistry SK, Morris SM, Figert PL, Maley ME, et al. Trauma increases extrahepatic arginase activity. Surgery. 2000;127:419–426
  9. Gattinoni L, Powell DJ, Rosenberg SA, Restifo NP. Adoptive immunotherapy for cancer: building on success. Nat Rev Immunol. 2006;6:383–393
  10. Casas-Rodera P, Gomez-Candela C, Benitez S, Mateo R, Armero M, Castillo R, et al. Immunoenhanced enteral nutrition formulas in head and neck cancer surgery: a prospective, randomized clinical trial. Nutr Hosp. 2008;23:105–110
  11. Park KG, Heys SD, Blessing K, Kelly P, McNurlan MA, Eremin O, et al. Stimulation of human breast cancers by dietary L-arginine. Clin Sci (Lond). 1992;82:413–417
  12. Philip R, Campbell E, Wheatley DN. Arginine deprivation, growth inhibition and tumor cell death: 2. enzymatic degradation of arginine in normal and malignant cell cultures. Br J Cancer. 2003;88:613–623
  13. Wheatley DN, Philip R, Campbell E. Arginine deprivation, and tumor cell death: arginase and its inhibition. Mol Cell Biochem. 2003;244:177–185
  14. Fukumura D, Yonei Y, Kurose I, Saito H, Ohishi T, Higuchi H, et al. Role in nitric oxide in Kupffer cell–mediated hepatoma cell cytotoxicity in vitro and ex vivo. Hepatology. 1996;24:141–149
  15. Cifone MG, Festuccia C, Cironi L, Cavallo G, Chessa MA, Pensa V, et al. Induction of the nitric oxide–synthesizing pathway in fresh and interleukin 2–cultured rat natural killer cells. Cell Immunol. 1994;157:181–194
  16. Mordan LJ, Burnett TS, Zhang LX, Tom J, Cooney RV. Inhibitors of endogenous nitrogen oxide formation block the promotion of neoplastic transformation in C3H 10T1/2 fibroblasts. Carcinogenesis. 1993;14:1555–1559
  17. Gottke M, Chadee K. Exogenous nitric oxide stimulates mucin secretion from LS174T colonic adenocarcinoma cells. Inflamm Res. 1996;45:209–212
  18. Department of Health, Taiwan. Top 10 leading causes of death in Taiwan; 2009. Available at: www.doh.gov.tw.
  19. Vissers YL, Dejong CH, Luiking YC, Fearon KC, von Meyenfeldt MF, Deutz NE. Plasma arginine concentrations are reduced in cancer patients: evidence for arginine deficiency?. Am J Clin Nutr. 2005;81:1142–1146
  20. Thomsen LL, Lawton FG, Knowles RG, Beesley JE, Riveros-Moreno V, Moncada S. Nitric oxide synthase activity in human gynecological cancer. Cancer Res. 1994;54:1352–1354
  21. Wheatley DN, Scott L, Lamb J, Smith S. Single amino acid (arginine) restriction: growth and death of cultured HeLa and human diploid fibroblasts. Cell Physiol Biochem. 2000;10:37–55
  22. Thomsen LL, Scott JM, Topley P, Knowles RG, Keerie AJ, Frend AJ. Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor. Cancer Res. 1997;57:3300–3304
  23. Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest. 1973;52:2745–2756
  24. Malinda KM, Sidhu GS, Banaudha KK, Gaddipati JP, Maheshwari RK, Goldstein AL, et al. Thymosin alpha 1 stimulates endothelial cell migration, angiogenesis, and wound healing. J Immunol. 1998;160:1001–1006
  25. Efron D, Barbul A. Role of arginine in immunonutrition. J Gastroenterol. 2000;35(suppl 12):20–23
  26. Braga M, Gianotti L, Vignali A, Carlo VD. Preoperative oral arginine and n-3 fatty acid supplementation improves the immunometabolic host response and outcome after colorectal resection for cancer. Surgery. 2002;132:805–814
  27. Rose DP, Connolly JM. Regulation of tumor angiogenesis by dietary fatty acids and eicosanoids. Nutr Cancer. 2000;37:119–127
  28. Dobbs SP, Hewett PW, Johnson IR, Carmichael J, Murray JC. Angiogenesis is associated with vascular endothelial growth factor expression in cervical intraepithelial neoplasia. Br J Cancer. 1997;76:1410–1415
  29. Asahara T, Bauters C, Zheng LP, Takeshita S, Bunting S, Ferrara N, et al. Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo. Circulation. 1995;92(suppl):II365–71
  30. Messina EJ, Weiner R, Kaley G. Prostaglandins and local circulatory control. Fed Proc. 1976;35:2367–2375
  31. Cheng T, Cao W, Wen R, Steinberg RH, LaVail MM. Prostaglandin E2 induces vascular endothelial growth factor and basic fibroblast growth factor mRNA expression in cultured rat Muller cells. Invest Ophthalmol Vis Sci. 1998;39:581–591
  32. Vihinen P, Kahari VM. Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets. Int J Cancer. 2002;99:157–166
  33. Brooks PC, Clark RA, Cheresh DA. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science. 1994;264:569–571
  34. Sipkins DA, Cheresh DA, Kazemi MR, Nevin LM, Bednarski MD, Li KC. Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging. Nat Med. 1998;4:623–626
  35. Ma Q, Wang Y, Gao X, Ma Z, Song Z. L-arginine reduces cell proliferation and ornithine decarboxylase activity in patients with colorectal adenoma and adenocarcinoma. Clin Cancer Res. 2007;13:7407–7412
  36. Jenkins DC, Charles IG, Thomsen LL, Moss DW, Holmes LS, Baylis SA, et al. Roles of nitric oxide in tumor growth. Proc Natl Acad Sci U S A. 1995;92:4392–4396
  37. Wink DA, Vodovotz Y, Laval J, Laval F, Dewhirst MW, Mitchell JB. The multifaceted roles of nitric oxide in cancer. Carcinogenesis. 1998;19:711–721
  38. Montrucchio G, Lupia E, de Martino A, Battaglia E, Arese M, Tizzani A, et al. Nitric oxide mediates angiogenesis induced in vivo by platelet-activating factor and tumor necrosis factor-alpha. Am J Pathol. 1997;151:557–563
  39. Maeda H, Noguchi Y, Sato K, Akaike T. Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthase inhibitor. Jpn J Cancer Res. 1994;85:331–334

 This study was supported by research grant 95TMU-WFH-06 from Taipei Medical University–Associated Wan Fang Hospital, Taipei, Taiwan.

PII: S0899-9007(09)00338-4

doi: 10.1016/j.nut.2009.08.004

Nutrition
Volume 26, Issue 7 , Pages 818-822 , July 2010