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Nutrition
Volume 26, Issue 6
, Pages 624-633
, June 2010
Intranasal insulin: From nose to brain
References
- . Inhaled insulin. Adv Drug Deliv Rev. 1999;35:235–247
- . Technosphere/insulin—a new approach for effective delivery of human insulin via the pulmonary route. Diabetes Technol Ther. 2002;4:589–594
- . The lung as a route for systemic delivery of therapeutic proteins and peptides. Respir Res. 2001;2:198–209
- . Liquid-spray or dry powder systems for inhaled delivery of peptide and proteins?. Am J Drug Deliv. 2005;3:29–45
- . Dry powder inhalation systems for pulmonary delivery of therapeutic peptides and proteins. Expert Opin Ther Pat. 2008;18:429–442
- . Inhaled cyclosporine—a breath of fresh air?. N Engl J Med. 2006;354:191–193
- . Central nervous system effects of intranasally administered insulin during euglycemia in men. Diabetes. 1999;48:557–563
- . Insulin given intranasally induces hypoglycaemia in normal and diabetic subjects. Br Med J (Clin Res Ed). 1982;284:303–306
- . Insulin administered intranasally as an insulin-bile salt aerosol: effectiveness and reproducibility in normal and diabetic subjects. Diabetes. 1983;32:1040–1047
- Intranasal aerosolized insulin. Mixed-meal studies and long-term use in type I diabetes. N Engl J Med. 1985;312:1078–1084
- . A new approach to the oral administration of insulin and other peptide drugs. Science. 1986;233:1081–1084
- . Preprandial intranasal insulin. Lancet. 1988;1:367–368
- Six month administration of gelified intranasal insulin in 16 type 1 diabetic patients under multiple injections: efficacy vs subcutaneous injections and local tolerance. Diabetes Metab. 2001;27:372–377
- . Intranasal administration of insulin with phospholipids as absorption enhancer: pharmacokinetics in normal subjects. Diabet Med. 1992;9:335–340
- . Long term use of intranasal insulin in insulin-dependent diabetic patients. Diabetes Care. 1987;10:573–578
- . Effects of intranasal insulin in non-obese type 2 diabetes. Diabetes Res Clin. 1987;3:197–202
- . Alternative routes of insulin delivery. Diabet Med. 2003;20:886–898
- . Alternative routes of administration as an approach to improve insulin therapy: update on dermal, oral, nasal and pulmonary insulin delivery. Curr Pharm Des. 2001;7:1327–1351
- . Exubera inhaled insulin: a review. Int J Clin Pract. 2004;58:394–401
- . Arguments against the use of inhaled insulin. Diabetes Technol Ther. 2007;9:S111–S114
- . Exubera gets lung cancer warning. Available at Medscape Medical News. April 9, 2008;http://www.medscape.comAccessed April 15, 2009
- . New insulin analogues and insulin delivery devices for the perioperative management of diabetic patients. Curr Opin Anaesthesiol. 2008;21:401–405
- . Postprandial physiology and the pathogenesis of type 2 diabetes mellitus. Insulin. 2008;3(suppl 2):132–140
- Intranasal insulin improves memory in humans. Psychoneuroendocrinology. 2004;29:1326–1334
- Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging. 2006;27:451–458
- Towards the therapeutic use of intranasal neuropeptide administration in metabolic and cognitive disorders. Regul Pept. 2008;149:79–83
- . Intranasal administration of insulin-like growth factor-I bypasses the blood–brain barrier and protects against focal cerebral ischemic damage. J Neurol Sci. 2001;187:91–97
- . Non-invasive intranasal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion. Neurosci Lett. 2001;308:91–94
- . Olfactory absorption of insulin to the brain. Drug Deliv. 1997;4:195–200
- . Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience. 2004;127:481–496
- Delivery of 125I-NGF to the brain via the olfactory route. Drug Deliv. 1997;4:87–92
- . Insulin-like growth factor-I and neurogenesis in the adult mammalian brain. Dev Brain Res. 2002;134:115–122
- . Nasal seroproteins, their physiology and pathology. Am J Rhinol. 2000;14:A–82
- . Nasal seroproteins: a new frontier in the exploration of physiology and pathology of nasal and sinus disease. In: Veldman JE, Passàli D, Lim DJ editor. New frontiers in immunobiology in otolaryngology. The Hague: Kugler; 2000;p. 127–152
- . Insulin is present in human saliva and nasal mucus. J Invest Med. 2006;54(suppl 2):S385
- . Insulin receptors as well as insulin are present in saliva and nasal mucus. J Invest Med. 2006;54(suppl 2):S378
- . A zinc protein isolated from human parotid saliva. Proc Natl Acad Sci U S A. 1975;72:488–492
- . cAMP and cGMP in nasal mucus: relationships to taste and smell dysfunction, gender and age. Clin Invest Med. 2008;31:E71–E77
- . cAMP and cGMP in nasal mucus related to severity of smell loss in patients with smell dysfunction. Clin Invest Med. 2008;31:E78–E84
- . Child to adult body mass index in the 1958 British birth cohort: associations with parental obesity. Arch Dis Child. 1997;77:376–381
- . Presence of insulin-like immunoreactivity and its biosynthesis in rat and human parotid gland. Diabetologia. 1982;22:358–361
- Detection of insulin and insulin-like growth factors I and II in saliva and potential synthesis in the salivary glands of mice. Effects of type 1 diabetes mellitus. Biochem Pharmacol. 1995;49:1521–1531
- . Salivary and plasma insulin levels in man. Biochem Mol Biol Int. 1993;30:623–629
- . Immunoreactive insulin in rat salivary glands and its dependence on age and serum insulin levels. Proc Soc Exp Biol Med. 1995;209:245–250
- Salivary immunoreactive insulin: a new entry in clinical chemistry?. Clin Chem. 1988;34:1478–1480
- . Characterization of immunoreactive insulin in human saliva: evidence against production in situ. Diebetologia. 1984;27:437–440
- Salivary insulin concentrations in type 2 (non–insulin-dependent) diabetic patients and obese non-diabetic subjects: relationship to changes in plasma insulin levels after an oral glucose load. Diabetologia. 1986;29:695–698
- . Turner's syndrome and carbohydrate metabolism. II. Parotid salivary insulin concentration in normal subjects and in patients with gonadal dysgenesis. Am J Med Sci. 1979;227:153–162
- Determination of insulin in human saliva using a more sensitive sandwich enzyme immunoassay. Anal Lett. 1988;21:381–394
- . The presence of immunologically reactive insulin in parotid saliva and its relation to changes in serum insulin concentration. Vox Sang. 1967;13:54–56
- . Salivary immunoreactive insulin concentrations are related to plasma free-insulin levels in insulin-treated diabetic patients. Diabetes Metab. 1990;16:16–20
- . Free insulin-like growth factor I (IGF-I) and IGF-II in human saliva. J Clin Endocrinol Metab. 1988;66:1014–1018
- . A normal population study of human salivary insulin-like growth factor 1 (IGF 1) concentrations from birth through puberty. J Clin Endocrinol Metab. 1992;74:774–778
- . Salivary insulin-like growth factor-I originates from local synthesis. J Endocrinol. 1992;135:85–90
- . Salivary gland hyperglycemic factor: an extrapancreatic source of glucagon-like material. Science. 1977;195:70–72
- Identification of ghrelin in human saliva: production by the salivary glands and potential role in proliferation of oral keratinocytes. Clin Chem. 2005;51:997–1006
- . Salivary EGF levels reduced in diabetic patients. J Diabetes Complications. 2000;14:140–145
- Total antioxidant capacity and levels of epidermal growth factor and nitric oxide in blood and saliva of insulin-dependent diabetic patients. Arch Med Res. 2005;36:376–381
- . Low parotid saliva calmodulin in patients with taste and smell dysfunction. Biochem Med Metab Biol. 1986;36:118–124
- . Calmodulin in saliva (letter to the editor). J Dent Res. 1997;76:1430
- . Fractionation of human parotid saliva. J Biol Chem. 1978;253:7556–7565
- . cAMP and cGMP in human parotid saliva: relationships to taste and smell dysfunction, gender and age. Am J Med Sci. 2007;334:431–440
- . Insulin is ubiquitous in extrapancreatic tissues of rats and humans. Proc Natl Acad Sci U S A. 1980;77:572–576
- . Extrapancreatic insulin-producing cells in multiple organs in diabetes. Proc Natl Acad Sci U S A. 2004;101:2458–2463
- The endocrine secretion of human insulin and growth hormone by exocrine glands of the gastrointestinal tract. Nat Biotechnol. 1997;15:1378–1382
- . Identification of insulin in the tear film and insulin receptor and IGF-1 receptor on the human ocular surface. Invest Ophthalmol Vis Sci. 2002;43:963–967
- . Synthesis and secretion of insulin-like growth factor and its binding protein by the perfused rat liver: dependence on growth hormone status. Endocrinology. 1983;113:297–305
- Regulated expression of human insulin in the liver of transgenic mice corrects diabetic alterations. FASEB J. 1994;8:440–447
- . Identification of human nasal mucous proteins using proteomics. Proteomics. 2005;5:2949–2959
- . Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa. Biochem Biophys Res Commun. 2004;323:429–436
- Purification, cloning and characterisation of odorant- and pheromone-binding proteins from pig nasal epithelium. Cell Mol Life Sci. 2001;58:823–834
- . Mucus of the human olfactory epithelium contains the insulin-like growth factor-I system which is altered in some neurodegenerative diseases. Brain Res. 1999;835:306–314
- . Insulin-like growth factor I is a possible pathogenic mechanism in nasal polyps. Acta Otolaryngol. 1988;106:156–160
- . Resorption of insulin and asthmolysin by the nasal mucous membrane. Acta Med Acad Sci Hung. 1958;12:107–114
- Localization and characterization of insulin receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry. Endocrinology. 1987;121:1562–1570
- . Localization of insulin-like immunoreactivity in the neurons from primary cultures of rat brain. Exp Cell Res. 1983;143:351–357
- . Identification of insulin in rat brain. Proc Natl Acad U S A. 1978;75:5737–5741
- . Insulin and insulin receptors in rodent brain. Diabetologia. 1981;20:268–273
- . Insulin in the brain. Annu Rev Physiol. 1987;49:335–347
- . Insulin receptors are widely distributed in the central nervous system of the rat. Nature. 1978;272:827–829
- . Autoradiographic localization of insulin receptors in rat brain: prominence in olfactory and limbic areas. Neuroscience. 1986;17:1127–1138
- . Localization of insulin receptor mRNA in rat brain by in situ hybridization. Endocrinology. 1990;127:3234–3236
- . Quantitative autoradiographic localization of [125I]insulin-like growth factor I, [125I]insulin-like growth factor II, and [125I]insulin receptor binding sites in developing and adult rat brain. J Comp Neurol. 1993;333:375–397
- . Receptors for insulin-like growth factors I and II: autoradiographic localization in rat brain and comparison to receptors for insulin. Endocrinology. 1988;123:2089–2099
- . Insulin receptors and insulin action in the brain: review and clinical implications. Neurosci Biobehav Rev. 2000;24:855–872
- . Regional concentrations of insulin in the rat brain. Endocrinology. 1983;112:898–903
- . Concentrations of insulin and insulin receptors in the brain are independent of peripheral insulin levels. Studies of obese and streptozotocin-treated rodents. J Clin Invest. 1979;64:636–642
- . Structural differences between insulin receptors in the brain and peripheral target tissues. J Bio Chem. 1983;258:8527–8530
- . Unique features of the insulin receptor in rat brain. J Neurochem. 1984;43:1302–1309
- Discrete brain areas express the insulin-responsive glucose transporter GLUT4. Mol Brain Res. 1996;38:45–53
- . Expression and localization of insulin-regulatable glucose transporter (GLUT4) in rat brain. Neurosci Lett. 1996;213:103–106
- . Glucose transporter proteins in brain: delivery of glucose to neurons and glia. Glia. 1997;21:2–21
- . Intracerebroventricular insulin produces nonuniform regional increases in sympathetic nerve activity. Am J Physiol Regul Integr Comp Physiol. 1994;267:R1350–R1355
- . Direct insulin signaling of neurons reverses diabetic neuropathy. Diabetes. 2004;53:1824–1830
- . Insulin and insulin-like growth factor II permit nerve growth factor binding and the neurite formation response in cultured human neuroblastoma cells. Proc Natl Acad Sci U S A. 1984;81:2562–2566
- . Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons. J Neurosci. 1986;6:1211–1219
- . Insulin receptor binding kinetics: modeling and simulation studies. J Theor Biol. 2000;205:355–364
- . Central insulin administration maintains reproductive behavior in diabetic female rats. Neuroendocrinology. 2003;78:90–95
- . Brain glucose sensing, counterregulation, and energy homeostasis. Physiology (Bethesda). 2007;22:241–251
- . Brain insulin: regulation, mechanisms of action and functions. Cell Mol Neurobiol. 2003;23:873–874
- . Insulin attenuates ischemic brain damage independent of its hypoglycemic effect. J Cereb Blood Flow Metab. 1991;11:1006–1014
- Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease. J Neural Transm. 1998;105:423–438
- . Insulin protects brain tissue against focal ischemia in rats. Neurosci Lett. 1992;144:121–123
- . Signaling by insulin-like growth factor 1 in brain. Eur J Pharmacol. 2004;490:25–31
- . The insulin receptor of rat brain is coupled to tyrosine kinase activity. J Biol Chem. 1984;259:3470–3474
- . Impairment of hippocampal neurogenesis in streptozotocin-treated diabetic rats. Acta Neurol Scand. 2008;117:205–210
- . Neurophysiological changes in the central and peripheral nervous system of streptozotocin-diabetic rats. Brain. 1999;122:757–768
- . NMDA receptor subunits are modified transcriptionally and post-translationally in the brain of streptozotocin-diabetic rats. Diabetologia. 1999;42:693–701
- . Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein. J Neurochem. 2007;101:757–770
- . Experimental diabetic neuropathy: an update. Diabetologia. 1999;42:773–788
- . Nerve blood flow in early experimental diabetes in rats: relation to conduction deficits. Am J Physiol Endocrinol Metab. 1991;261:E1–E8
- . Death of retinal neurons in streptozotocin-induced diabetic mice. Invest Ophthalmol Vis Sci. 2004;45:3330–3336
- . Selective delivery of insulin into the brain: intraolfactory absorption. Int J Pharm. 1996;140:77–83
- . Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans. Physiol Behav. 2004;83:47–54
- Role of brain insulin receptor in control of body weight and reproduction. Science. 2000;289:2122–2125
- . Insulin receptors in brain tied to appetite and weight gain. Available at Health Newsletter. October 2000;http://www.mercola.comAccessed April 15, 2009
- . Transfer of dopamine in the olfactory pathway following nasal administration in mice. Pharm Res. 2000;17:737–742
- . Role of dopamine transporter (DAT) in dopamine transport across the nasal mucosa. Life Sci. 2006;79:1391–1398
- Delivery of 125I-NGF to the brain via the olfactory route. Int J Pharm Drug Del. 1997;4:87–92
- . Direct nose-to-brain transfer of morphine after nasal administration to rats. Pharm Res. 2006;23:565–572
- . Evaluation of direct transport pathways of glycine receptor antagonists and an angiotensin antagonist from the nasal cavity to the central nervous system in the rat model. Pharm Res. 2008;25:1531–1543
- Intranasally delivered TGF-β1 enters brain and regulates gene expressions of its receptors in rats. Brain Res Bull. 2007;74:271–277
- . Transport of hydroxyzine and triprolidine across bovine olfactory mucosa: role of passive diffusion in the direct nose-to-brain uptake of small molecules. Int J Pharm. 2005;302:133–144
- . Intranasal drug delivery for brain targeting. Curr Drug Deliv. 2005;2:165–175
- Enhanced brain targeting efficiency of intranasally administered plasmid DNA: an alternative route for brain gene therapy. J Mol Med. 2007;85:75–83
- . Pharmacokinetics of substrate uptake and distribution in murine brain after nasal instillation. Pharm Res. 2005;22:235–244
- . Transport of molecules from nose to brain: transneuronal anterograde and retrograde labeling in the rat olfactory system by wheat germ agglutinin-horseradish peroxidase applied to the nasal epithelium. Brain Res Bull. 1983;15:129–142
- . From nose to brain: understanding transport capacity and transport rate of drugs. Expert Opin Drug Deliv. 2008;5:1159–1168
- Daily nasal inoculation with the insulin gene ameliorates diabetes in mice. Diabetes Res Clin Pract. 2004;63:1–9
- . Levels of dopamine in blood and brain following nasal administration to rats. Eur J Pharm Sci. 2001;14:75–80
- . Quantitative analysis of the olfactory pathway for drug delivery to the brain. Brain Res. 1995;692:278–282
- . Bioavailability of intranasal scopolamine in normal subjects. J Pharm Sci. 1996;85:899–902
- . Issues in intranasal neuropeptide uptake. In: Kobiler D, Lustig S, Shapiro S editor. Blood–brain barrier: drug delivery and brain pathology. New York: Springer; 2001;p. 331
- . Is nose-to-brain transport of drugs in man a reality?. J Pharm Pharmacol. 2004;56:3–17
- . Inhaled iron, unlike manganese, is not transported to the rat brain via the olfactory pathway. Toxicol Appl Pharmacol. 2003;193:116–126
- . Olfactory uptake of manganese requires DMT1 and is enhanced by anemia. FASEB J. 2007;21:223–230
- . Accumulation of Cd(II) in the CNS depending on the route of administration: intraperitoneal, intratracheal, or intranasal. Toxicol Sci. 1992;19:275–278
- . Direct transport of cocaine from the nasal cavity to the brain following intranasal cocaine administration in rats. J Pharm Sci. 1995;88:754–758
- . Olfactory transport: a direct route of delivery of inhaled manganese phosphate to the rat brain. J Toxicol Environ Health A. 2002;65:1493–1511
- . Correlation of brain magnetic resonance imaging changes with pallidal manganese concentrations in rhesus monkeys following subchronic manganese inhalation. Toxicol Sci. 2006;92:219–227
- . Pheromones in mice: reciprocal interaction between the nose and brain. Nature. 1982;296:148–150
- Detection of mouse-adapted human influenza virus in the olfactory bulbs of mice within hours after intranasal infection. J Neurovirol. 2007;13:399–409
- . Nasal toxicity, carcinogenicity, and olfactory uptake of metals. Ann Clin Lab Sci. 2001;31:3–24
- Trigeminal uptake and clearance of inhaled manganese chloride in rats and mice. Neurotoxicology. 2005;26:113–123
- . Olfactory perception, communication, and the nose-to-brain pathway. Physiol Behav. 2004;83:3–11
- . Insulin-like growth factors cross the blood–brain barrier. Endocrinology. 1994;135:1753–1761
- . Intranasal leptin: blood–brain barrier bypass (BBBB) for obesity?. Endocrinology. 2006;147:2086–2087
- . Nasal absorption of (S)-UH-301 and its transport into the cerebrospinal fluid in rats. Int J Pharm. 2000;195:197–205
- . The source of cerebral insulin. Eur J Pharm. 2004;490:5–12
- . Human blood–brain barrier insulin receptor. J Neurochem. 1985;44:1771–1778
- . Microspheres as nasal drug delivery systems. Adv Drug Deliv Rev. 1998;29:185–194
- . Dextran microspheres as a potential nasal drug delivery system for insulin–in vitro and in vivo properties. Int J Pharm. 1995;124:37–44
- . Preparation and in vitro characterization of mucoadhesive polymeric microspheres as intra-nasal delivery systems. Eur J Pharm Biopharm. 1997;44:53–60
- . Cyclodextrins as nasal absorption promoters of insulin: mechanistic evaluations. Pharm Res. 1992;9:1157–1163
- . Chitosan as a novel delivery system for peptide drugs. Pharm Res. 1994;11:1186–1189
- . Effects of absorption enhancers on human nasal tissue ciliary movement in vitro. Pharm Res. 1990;7:144–146
- Intranasal delivery of recombinant human growth hormone (somatropin) in sheep using chitosan-based powder formulations. Eur J Pharm Sci. 2005;26:9–15
- . Distribution and clearance of bioadhesive formulations from the olfactory region in man: effect of polymer type and nasal delivery device. Eur J Pharm Sci. 2007;30:295–302
- . Preparation of nimodipine-loaded microemulsion for intranasal delivery and evaluation on the targeting efficiency to the brain. Int J Pharm. 2004;275:85–96
- . Scintigraphic method to quantify the passage from brain parenchyma to the deep cervical lymph nodes in rats. Eur J Nucl Med. 1987;13:456–461
- . Albumin outflow into deep cervical lymph from different regions of rabbit brain. Am Physiol Heart Circ Physiol. 1991;261:H1197–H1204
- . Pheromones and animal behaviour: communication by smell and taste. New York: Cambridge University Press; 2003;
- . Menstrual synchorony and suppression. Nature. 1971;329:244–245
- In: Houck LD, Drickamer LC editor. Foundations of animal behavior: classic papers with commentaries. Chicago: University of Chicago Press; 1996;
- . Pheromones (ectohormones) in insects. Annu Rev Entomol. 1959;4:39–58
- . Primate sex pheromones of vaginal origin. Nature. 1970;225:84–85
- . Brain potential changes after intranasal vs. intravenous administration of vasopressin: evidence for a direct nose–brain pathway for peptide in humans. Biol Psychiatry. 1996;39:332–340
- . Nasal drug delivery system–factors affecting and applications. Curr Drug Deliv. 2007;2:27–38
PII: S0899-9007(09)00333-5
doi: 10.1016/j.nut.2009.08.003
© 2010 Elsevier Inc. All rights reserved.
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Nutrition
Volume 26, Issue 6
, Pages 624-633
, June 2010
