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Nutrition
Volume 26, Issue 1
, Pages 33-39
, January 2010
Inhaled insulin—Intrapulmonary, intranasal, and other routes of administration: Mechanisms of action
References
- . Pancreatic extracts in the treatment of diabetes mellitus. Can Med Assoc J. 1922;12:141–146
- . Inhaled insulin. Adv Drug Deliv Rev. 1999;35:235–247
- . The lung as a route for systemic delivery of therapeutic proteins and peptides. Respir Res. 2001;2:198–209
- . Liquid-spray or dry powder systems for inhaled delivery of peptide and proteins?. Am J Drug Deliv. 2005;3:29–45
- . Dry powder inhalation systems for pulmonary delivery of therapeutic peptides and proteins. Expert Opin Ther Pat. 2008;18:429–442
- . Technosphere/Insulin—a new approach for effective delivery of human insulin via the pulmonary route. Diabetes Technol Ther. 2002;4:589–594
- . Variability of insulin absorption and insulin action. Diabetes Technol Ther. 2002;4:673–682
- . Sustained release of insulin from insoluble inhaled particles. Drug Dev Res. 1999;48:178–185
- . Bioengineering of therapeutic aerosols. Annu Rev Biomed Eng. 2002;4:93–107
- Inhaled insulin improves glycemic control when substituted for or added to oral combination therapy in type 2 diabetes: a randomized, controlled trial. Ann Intern Med. 2005;143:549–558
- . About inhalation of insulin. Klin Wochenschr. 1925;4:71
- . Intrapulmonary administration of insulin to healthy volunteers. J Intern Med. 1996;240:93–98
- . The lung as an alternative route of delivery for insulin in controlling postprandial glucose levels in patients with diabetes. Chest. 1998;114:1734–1739
- . Results of a dose-response study with a new insulin inhaler formulation. Diabetes. 2000;49:A75
- . Exubera inhaled insulin: a review. Int J Clin Pract. 2004;58:394–401
- Efficacy of inhaled human insulin in type 1 diabetes mellitus: a randomised proof-of-concept study. Lancet. 2001;357:331–335
- . Clinical pharmacokinetics and pharmacodynamics of inhaled insulin. Clin Pharmacokinet. 2004;43:781–801
- Dose–response relation of liquid aerosol inhaled insulin in Type I diabetic patients. Diabetologia. 2001;44:305–308
- . Inhaled insulin. Diabetes Technol Ther. 1999;1:307–313
- . New insulin analogues and routes of delivery: pharmacodynamic and clinical consideration. Clin Pharmacokinet. 2008;47:595–610
- . Factors affecting the deposition of aerosolized insulin. Diabetes Technol Ther. 2001;3:387–397
- . Tennis anyone? The lungs as a new court for systemic therapy. CMAJ. 1999;161:1287–1288
- . Mechanisms of macromolecule absorption by the lungs. Adv Drug Deliv Rev. 1996;19:3–36
- . Antibody response to inhaled insulin in patients with type 1 or type 2 diabetes. An analysis of initial phase II and III inhaled insulin (Exubera) trials and a two-year extension trial. J Clin Endocrinol Metab. 2005;90:3287–3294
- . Time–action profile of inhaled insulin. Diabet Med. 1997;14:63–72
- . Time to peak insulin level, relative bioavailability, and effect of site of deposition of nebulized insulin in patients with noninsulin-dependent diabetes mellitus. J Aerosol Med. 1998;11:153–173
- . Inhaled insulin: Exubera. Ann Pharmacother. 2005;39:843–853
- . Effects of intrapulmonary insulin in patients with non-insulin–dependent diabetes. Scand J Clin Lab Invest. 1996;56:555–561
- Efficacy and safety of inhaled insulin (Exubera) compared with subcutaneous insulin therapy in patients with type 2 diabetes: results of a 6-month, randomized, comparative trial. Diabetes Care. 2004;27:2356–2362
- . Clinical evaluation of inhaled insulin. Adv Drug Deliv Rev. 2006;58:1061–1075
- . Arguments against the use of inhaled insulin. Diabetes Technol Ther. 2007;9:S111–S114
- Waknine Y. Exubera gets lung cancer warning. Medscape Medical News, April 9, 2008. Available at: http://www.medscape.com. Accessed February 12, 2009.
- . The science behind Exubera. Drug Dev Res. 2008;69:130–137
- . Inhaled insulin's last gasp?. Nat Biotechnol. 2008;26:479–480
- . Inhaled insulin for diabetes mellitus. N Engl J Med. 2007;356:2107
- . Insulin is present in human saliva and nasal mucus. J Invest Med. 2006;54:S385
- . Insulin receptors as well as insulin are present in saliva and nasal mucus. J Invest Med. 2006;54:S378
- . Mucus of the human olfactory epithelium contains the insulin-like growth factor-I system which is altered in some neurodegenerative diseases. Brain Res. 1999;835:306–314
- . Nasal seroproteins: a new frontier in the exploration of physiology and pathology of nasal and sinus disease. In: Veldman JE, Passàli D, Lim DJ editor. New frontiers in immunobiology in otolaryngology. The Hague: Kugler; 2000;p. 127–152
- . Central nervous system effects of intranasally administered insulin during euglycemia in men. Diabetes. 1999;48:557–563
- . Olfactory absorption of insulin to the brain. Drug Deliv. 1997;4:195–200
- . Intranasal insulin improves memory in humans. Psychoneuroendocrinology. 2004;29:1326–1334
- Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging. 2006;27:451–458
- Towards the therapeutic use of intranasal neuropeptide administration in metabolic and cognitive disorders. Regul Pept. 2008;149:79–83
- . Intranasal administration of insulin-like growth factor-I bypasses the blood–brain barrier and protects against focal cerebral ischemic damage. J Neurol Sci. 2001;187:91–97
- . Non-invasive intranasal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion. Neurosci Lett. 2001;308:91–94
- . Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience. 2004;127:481–496
- . Insulin given intranasally induces hypoglycaemia in normal and diabetic subjects. Br Med J (Clin Res Ed). 1982;284:303–306
- . Insulin administered intranasally as an insulin-bile salt aerosol: effectiveness and reproducibility in normal and diabetic subjects. Diabetes. 1983;32:1040–1047
- Intranasal aerosolized insulin. Mixed-meal studies and long-term use in type I diabetes. N Engl J Med. 1985;312:1078–1084
- . A new approach to the oral administration of insulin and other peptide drugs. Science. 1986;233:1081–1084
- . Preprandial intranasal insulin. Lancet. 1988;1:367–368
- Six month administration of gelified intranasal insulin in 16 type 1 diabetic patients under multiple injections: efficacy vs subcutaneous injections and local tolerance. Diabetes Metab. 2001;27:372–377
- . Intranasal administration of insulin with phospholipids as absorption enhancer: pharmacokinetics in normal subjects. Diabet Med. 1992;9:335–340
- . Long term use of intranasal insulin in insulin-dependent diabetic patients. Diabetes Care. 1987;10:573–578
- . Effects of intranasal insulin in non-obese type 2 diabetes. Diabetes Res Clin. 1987;3:197–202
- Intranasal insulin therapy: the clinical realities. J Control Release. 1996;41:69–75
- . Drug metabolism in the nasal mucosa. Pharm Res. 1992;9:1–9
- . Enhancement of nasal absorption of insulin using chitosan nanoparticles. Pharm Res. 1999;16:1576–1581
- . Insulin delivery in nosedrops: new formulations containing alkylglycosides. Endocrinology. 1994;135:2386–2391
- . Nasal drug delivery—possibilities, problems and solutions. J Control Release. 2003;87:187–198
- Immediate but not long-term intranasal administration of insulin raises blood pressure in human beings. Metabolism. 2005;54:1356–1361
- . Are disease-modifying drugs for Alzheimer's already on the market?. Pract Neurol. 2008;7:14–15
- Intranasal insulin improves cognition and modulates beta-amyloid in early Alzheimer disease. Neurology. 2008;70:440–448
- . Alternative routes of insulin delivery. Diabet Med. 2003;20:886–898
- Biokinetics of buccal spray insulin in patients with type 1 diabetes. Metabolism. 2005;54:930–934
- . Comparison of nasal, rectal, buccal, sublingual and intramuscular insulin efficacy and the effects of a bile sale absorption promoter. J Pharmacol Exp Ther. 1988;244:23–27
- . Biopharmaceutic aspects of buccal absorption of insulin. Methods Find Exp Clin Pharmacol. 1990;12:205–212
- . Alternative routes of administration as an approach to improve insulin therapy: update on dermal, oral, nasal and pulmonary insulin delivery. Curr Pharm Des. 2001;7:1327–1351
PII: S0899-9007(09)00330-X
doi: 10.1016/j.nut.2009.08.001
© 2010 Elsevier Inc. All rights reserved.
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Nutrition
Volume 26, Issue 1
, Pages 33-39
, January 2010
