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Nutrition
Volume 26, Issue 5
, Pages 482-490
, May 2010
Three targets of branched-chain amino acid supplementation in the treatment of liver disease
References
- . Does leucine, leucyl-tRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle?. J Biol Chem. 1982;257:1613–1621
- . Regulation of protein synthesis by branched-chain amino acids. Curr Opin Clin Nutr Metab Care. 2001;4:39–43
- . Hormonal and signaling role of branched-chain amino acids. J Nutr. 2005;135:1547S–1552S
- . Metabolism of branched chain amino acids. In: Waterlow JC, Stephen JM editor. Nitrogen metabolism in man. London: Applied Science; 1981;p. 109–110
- . Ammonia production in muscle and other tissues. The purine nucleotide cycle. Physiol Rev. 1972;52:382–414
- . Mechanisms responsible for regulation of branched-chain amino acid catabolism. Biochem Biophys Res Commun. 2004;313:391–396
- . Branched-chain amino acids: enzyme and substrate regulation. J Nutr. 2006;136:207S–211S
- . Branched-chain amino acid metabolism. Annu Rev Nutr. 1984;4:409–454
- . Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat. J Clin Invest. 1989;83:1614–1622
- . Administration of endotoxin, tumor necrosis factor, or interleukin 1 to rats activates skeletal muscle branched-chain α-keto acid dehydrogenase. J Clin Invest. 1990;85:256–263
- . Leucine metabolism in TNF-α- and endotoxin-treated rats: contribution of hepatic tissue. Am J Physiol Endocrinol Metab. 1997;273:E1052–E1058
- Branched chain metabolic support. A prospective, randomized, double-blind trial in surgical stress. Ann Surg. 1984;199:286–291
- . General and specialized parenteral amino acid formulations for nutrition support. J Am Diet Assoc. 1990;90:401–408
- . The metabolic role of branched-chain amino acids. Nutrition. 2002;18:287–288
- . Therapeutic use of branched-chain amino acids in burn, trauma and sepsis. J Nutr. 2006;136:308S–313S
- . Pharmacological activities of branched-chain amino acids: augmentation of albumin synthesis in liver and improvement of glucose metabolism in skeletal muscle. Hepatol Res. 2004;30S:19–24
- Nutritional supplementation with branched-chain amino acids in advanced cirrhosis: a double-blind, randomized trial. Gastroenterology. 2003;124:1792–1801
- . Branched-chain amino acid supplementation in patients with liver diseases. J Nutr. 2005;135:1596S–1601S
- . Role of branched-chain amino acids in liver disease: the evidence for and against. Curr Opin Clin Nutr Metab Care. 2007;10:297–303
- Hepatic Nutritional Therapy (HNT) Study Group. BCAA-enriched snack improves nutritional state of cirrhosis. Nutrition. 2007;23:113–120
- . Attempting to predict the unpredictable in acute liver injury. J Hepatol. 2005;42:5–6
- . Plasma amino acid patterns in hepatic encephalopathy of differing etiology. Gastroenterology. 1977;72:483–487
- . Amino acid disturbances in experimental hepatic coma rats. Int J Artif Org. 1984;7:197–202
- Abnormal phenylalanine hydroxylation and tyrosine oxidation in a patient with acute fulminant liver disease with correction by liver transplantation. Gastroenterology. 1985;89:659–663
- . Plasma amino acids in four models of experimental liver injury in rats. Amino Acids. 1996;10:229–241
- . Plasma amino acid levels after carbon tetrachloride induced acute liver damage. A dose–response and time–response study in rats. Amino Acids. 1999;16:1–11
- . Plasma and brain amino acids in fulminant hepatic failure and their relationship to hepatic encephalopathy. Eur J Clin Invest. 1976;6:387–394
- . Free amino acids in plasma and muscle following total removal of the liver. J Biol Chem. 1951;192:293–300
- . The plasma amino acids in patients with liver failure. J Lab Clin Med. 1957;50:417–425
- . Why are plasma branched chain amino acid levels diminished in patients with liver cirrhosis?. In: Adibi SA, Fekl W, Langenbeck U, Schauder P editor. Branched chain amino and keto acids in health and disease. Basel: Karger; 1984;p. 483–496
- Insulin and glucagon levels in liver cirrhosis. Relationship with plasma amino acid imbalance of chronic hepatic encephalopathy. Dig Dis Sci. 1979;24:594–601
- . Intravenous infusion of alpha-oxoisocaproate: influence on amino acid and nitrogen metabolism in patients with liver cirrhosis. Clin Sci (Lond). 1982;62:285–293
- Evaluation of the effects of combination therapy with branched-chain amino acid and zinc supplements on nitrogen metabolism in liver cirrhosis. Hepatol Res. 2007;37:615–619
- . Clearance rate of plasma branched-chain amino acids correlates significantly with blood ammonia level in patients with liver cirrhosis. Int Hepatol Commun. 1995;3:91–96
- . Hyperammonemia-induced depletion of glutamate and branched-chain amino acids in muscle and plasma. J Hepatol. 1996;25:756–762
- . Effect of hyperammonemia on leucine and protein metabolism in rats. Metabolism. 2000;49:1330–1334
- . The cerebral and peripheral uptake of ammonia in liver disease with a hypothesis for the mechanism of hepatic coma. J Clin Invest. 1955;34:622–628
- . Pathogenesis and treatment of portal-systemic encephalopathy: an update. Dig Dis Sci. 1992;37:321–327
- . Branched chain amino acids in hepatic encephalopathy. Am J Surg. 2002;183:424–429
- . Mechanisms of hyperammonemia. Clin Chem Lab Med. 2002;40:653–662
- . Glutamine in the central nervous system: function and dysfunction. Front Biosci. 2007;12:332–343
- NMDA receptors in hyperammonemia and hepatic encephalopathy. Metab Brain Dis. 2007;22:321–335
- . Role of NMDA receptors in acute liver failure and ammonia toxicity: therapeutical implications. Neurochem Int. 2009;55:113–118
- . Chronic hyperammonemia impairs the glutamate-nitric oxide-cyclic GMP pathway in cerebellar neurons in culture and in the rat in vivo. Eur J Neurosci. 1998;10:3201–3209
- . False neurotransmitters and hepatic failure. Lancet. 1971;ii:75–80
- The role of plasma amino acids in hepatic encephalopathy. Surgery. 1975;78:276–290
- . The effect of normalization of plasma amino acids on hepatic encephalopathy in man. Surgery. 1976;80:77–91
- . Branched-chain–enriched amino acid solutions in patients with liver failure: an early example of nutritional pharmacology. JPEN. 1990;14(suppl):249S–256S
- . Amino acid, ammonia and neurotransmitter concentrations in hepatic encephalopathy: serial analysis in plasma and cerebrospinal fluid during treatment with an adapted amino acid solution. Klin Wochenschr. 1984;62:867–875
- . Visual evoked potential recordings in hepatic encephalopathy and their variations during branched chain amino-acid treatment. Hepatogastroenterology. 1985;32:3–7
- . Use of branched chain amino acids for treating hepatic encephalopathy: clinical experiences. Gut. 1986;27(suppl 1):111–115
- Long-term treatment of latent portosystemic encephalopathy with branched-chain amino acids. A double-blind placebo-controlled crossover study. J Hepatol. 1993;17:308–314
- Is intravenous administration of branched chain amino acids effective in the treatment of hepatic encephalopathy? A multicenter study. Hepatology. 1983;3:475–480
- . Lack of preventive effect of branched-chain amino acid solution on postoperative hepatic encephalopathy in patients with cirrhosis: a randomized, prospective trial. Surgery. 1988;104:482–488
- . Branched-chain amino acids for hepatic encephalopathy. Cochrane Database Syst Rev. 2003;2:CD001939
- . Stimulation of muscle ammonia production during exercise following branched-chain amino acid supplementation in humans. J Physiol. 1996;493:909–922
- Ischemia–reperfusion injury in rat fatty liver: role of nutritional status. Hepatology. 1999;29:1139–1146
- . Preoperative oral carbohydrate nutrition: an update. Curr Opin Clin Nutr Metab Care. 2001;4:255–259
- . Hepatic protection by perioperative metabolic support?. Nutrition. 2008;24:1217–1219
- . Different effects of glucose and intralipid on the onset of liver regeneration in the early period after partial hepatectomy in the rat. Exp Pathol. 1988;33:257–260
- . Nutritional impact on the final outcome of liver injury inflicted by model hepatotoxicants: effect of glucose loading. FASEB J. 1995;9:240–245
- . Nutritional modulation of liver regeneration by carbohydrates, lipids, and amino acids: a review. Nutrition. 1999;15:784–788
- . Role of metabolic overload in the inhibition of DNA synthesis following partial hepatectomy in the rats. Eur Surg Res. 1984;16:294–302
- . Acceleration of the onset of liver regeneration by carnitine in partially hepatectomized rats. Physiol Bohemoslov. 1989;38:503–508
- . Effect of polyunsaturated phosphatidylcholine on liver regeneration onset after hepatectomy in the rat. Arzneim Forsch Drug Res. 1992;42:337–339
- . Use of polyunsaturated phosphatidyl choline in HBsAg negative chronic active hepatitis: results of prospective double-blind controlled trial. Liver. 1982;2:77–81
- Metabolic responses to lipid infusions in patients with liver cirrhosis. Clin Nutr. 1992;11:193–206
- . Fat emulsion in surgical patients with liver disorders. J Surg Res. 1989;47:59–64
- . Effect of branched-chain amino acids on liver regeneration after partial hepatectomy. Physiol Bohemoslov. 1985;34:359–366
- . Effect of amino acid infusion on liver regeneration after partial hepatectomy in the rat. JPEN. 1986;10:17–20
- . Effect of glucose and branched chain amino acids (BCAA) infusion on onset of liver regeneration and plasma amino acid pattern in partially hepatectomized rat. J Hepatol. 1991;13:14–20
- . Prospective randomized control study on the effect of branched-chain amino acids in patients with liver resection for hepatocellular carcinoma. Aust N Z J Surg. 1999;69:811–815
- Usefulness of granular BCAA after hepatectomy for liver cancer complicated with liver cirrhosis. Nutrition. 2005;21:480–486
- . Long-term oral administration of branched chain amino acids after curative resection of hepatocellular carcinoma: a prospective randomized trial. Br J Surg. 1997;84:1525–1531
- . Synergistic action of glucagon and insulin in regulation of hepatic regeneration. Adv Enzyme Regul. 1975;13:281–293
- Leucine stimulates the secretion of hepatocyte growth factor by hepatic stellate cells. Biochem Biophys Res Commun. 2002;297:1108–1111
- Effect of glutamine supplement and hepatectomy on DNA and protein synthesis in the remnant liver. J Surg Res. 1995;59:475–481
- . Effects of glutamine administration on liver regeneration following hepatectomy. Nutrition. 1999;15:23–28
- Cachexia: a new definition. Clin Nutr. 2008;27:793–799
- . Alcohol and nutrition. Br Med Bull. 1982;38:21–29
- . Branched-chain amino acid enriched supplements as therapy for liver disease. J Nutr. 2006;136:295S–298S
- . Body composition, muscle function, and energy expenditure in patients with liver cirrhosis: a comprehensive study. Am J Clin Nutr. 2007;85:1257–1266
- . Glucose resistance contributes to diabetes mellitus in cirrhosis. Hepatology. 1993;18:284–291
- . Preferential use of branched-chain amino acids as an energy substrate in patients with liver cirrhosis. Intern Med. 1998;37:429–434
- . Leucine metabolism in cirrhotic rats. J Hepatol. 1996;24:209–216
- . Protein turnover in acute and chronic liver disease. Acta Chir Scand. 1980;507:91–100
- Assessment of the carbon tetrachloride-induced cirrhosis model for studies of nitrogen metabolism in chronic liver disease. Ann Nutr Metab. 1994;38:238–248
- . Elevated protein requirements in cirrhosis of the liver investigated by whole-body protein turnover studies. Clin Sci. 1988;75:101–107
- . Body protein metabolism and plasma amino acids in cirrhosis of the liver. The effect of varying the branched chain amino acid content of intravenous amino acid solutions. Clin Nutr. 1984;3:153–162
- In vivo measurement of leucine metabolism with stable isotopes in normal subjects and in those with cirrhosis fed conventionally? And branched-chain amino acid–enriched diets. Surgery. 1985;98:405–412
- Leucine metabolism in stable cirrhosis. Hepatology. 1986;6:622–663
- Basal energy production rate and substrate use in stable cirrhotic patients. Hepatology. 1990;12:106–112
- . Ammonia inhibits protein synthesis in slices from young rat brain. J Neurochem. 1984;42:644–646
- . Inhibition of protein degradation in isolated hepatocytes. Biochem J. 1977;164:399–407
- . Amino acids as regulators of proteolysis. J Nutr. 2003;133:2052S–2056S
- . Improvement in body composition after transjugular intrahepatic portosystemic stent-shunt (TIPS) in patients with cirrhosis. Gastroenterology. 1999;116:A1274
- . Protein metabolism in cirrhotic rats: effect of dietary restriction. Ann Nutr Metab. 1995;39:346–354
- . Effect of alanyl-glutamine on leucine and protein metabolism in endotoxemic rats. JPEN. 2000;24:215–222
- . Relation between glutamine, branched-chain amino acids, and protein metabolism. Nutrition. 2002;18:130–133
- . Effects of lipopolysaccharide endotoxin on the insulin-like growth factor I system in rats with cirrhosis. Vivo. 2008;22:655–661
- . Nutrient-induced thermogenesis and protein-sparing effect by rapid infusion of a branched chain–enriched amino acid solution to cirrhotic patients. J Med. 1996;27:176–182
- . Endotoxin disrupts the leucine-signaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle. J Cell Physiol. 2005;203:144–155
- . The role of leucine in the regulation of protein metabolism. J Nutr. 2005;135:1553S–1556S
- . Branched-chain amino acid-enriched supplementation improves insulin resistance in patients with chronic liver disease. Int J Mol Med. 2008;22:105–112
- . Effect of leucine and metabolites of branched chain amino acids on protein turnover in heart. J Biol Chem. 1979;254:8358–8362
- . Effect of beta-hydroxy-beta-methylbutyrate (HMB) on protein metabolism in whole body and in selected tissues. Food Chem Toxicol. 2009;47:255–259
- A comparison of parenteral hyperalimentation and early enteral feeding regarding systemic immunity after major hepatic resection—the results of a randomized prospective study. Hepatogastroenterology. 1997;44:205–209
- . Inhibitory effect of aroma on the bitterness of branched-chain amino acid solutions. Chem Pharm Bull (Tokyo). 2007;55:1581–1584
- . Branched chain amino acids supplemented with L-acetylcarnitine versus BCAA treatment in hepatic coma: a randomized and controlled double blind study. Eur J Gastroenterol Hepatol. 2009;21:762–770
- . Augmented utilization of branched-chain amino acids by skeletal muscle in decompensated liver cirrhosis in special relation to ammonia detoxication. Gastroenterol Jpn. 1981;16:64–70
This work was supported by Research Project MSM 0021620820.
PII: S0899-9007(09)00308-6
doi: 10.1016/j.nut.2009.06.027
© 2010 Elsevier Inc. All rights reserved.
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Nutrition
Volume 26, Issue 5
, Pages 482-490
, May 2010
