« Previous
Next »
Nutrition
Volume 26, Issue 7
, Pages 760-765
, July 2010
Melanocortin-3 receptor gene variants: Association with childhood obesity and eating behavior in Chilean families
References
- . Nutrition transition in Chile. Determinants and consequences. Public Health Nutr. 2002;5:123–128
- . Trends in overweight and obesity prevalence in Chilean children: comparison of three definitions. Eur J Clin Nutr. 2002;56:200–204
- . The genetics of human obesity. Nat Genet Rev. 2005;6:221–234
- . The critical role of the melanocortin system in the control of energy balance. Annu Rev Nutr. 2004;24:133–149
- Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 1997;88:131–141
- Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet. 2000;26:97–102
- . Differential role of melanocortin receptor subtypes in cachexia. Endocrinology. 2003;144:1513–1523
- . Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med. 2003;348:1085–1095
- Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet. 2008;40:768–775
- . The leptin melanocortin pathway and the control of body weight: lessons from human and murine genetics. Obes Rev. 2007;8:293–306
- . Functional characterization of melanocortin-3 receptor variants identifies a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation. J Clin Endocrinol Metab. 2004;89:3936–3942
- . O'Rahilly. Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity. Nat Clin Pract Endocrinol Metab. 2008;4:569–577
- Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q. J Clin Invest. 1997;100:1240–1247
- . Genomewide linkage analysis of weight change in the Framingham Heart Study. J Clin Endocrinol Metab. 2005;90:3197–3201
- Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet. 2009;41:18–24
- Co-occurrence of two partially inactivating polymorphisms of MC3R is associated with pediatric-onset obesity. Diabetes. 2005;54:2663–2667
- Melanocortin-3-receptor gene variants in morbid obesity. Int J Obes Relat Metab Disord. 2003;27:70–74
- Association of functionally significant melanocortin-4 but not melanocortin-3 receptor mutations with severe adult obesity in a large North American case–control study. Hum Mol Genet. 2009;18:1140–1147
- . Development of the Children's Eating Behavior Questionnaire. J Child Psychol Psychiatry. 2001;42:963–970
- The Three-Factor Eating Questionnaire-R18 is able to distinguish among different eating patterns in a general population. J Nutr. 2004;134:2372–2380
- Centers for Disease Control and Prevention/National Center for Health Statistics. CDC growth charts: United States. Available at: http://www.cdc.gov/growth chart. Accessed May 30, 2000.
- . The role of melanocortin receptor gene in childhood obesity. Diabetes. 2007;56:2622–2630
- . Dinucleotide repeat polymorphism in a gene on chromosome 20 encoding a G-protein coupled receptor (D20S32e). Nucleic Acids Res. 1991;19:2519
- . Eating behavior and childhood obesity: family influences. Arch Latinoam Nutr. 2008;58:249–255
- . A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics. 1995;29:311–322
- . The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet. 1996;59:983–989
- . Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol. 2003;25:115–121
- . Genetic and environmental influences on eating behavior: the Swedish Young Male Twins Study. Am J Clin Nutr. 2005;81:564–569
- . Genetic influence on appetite in children. Int J Obes Relat Metab Disord. 2008;32:1468–1473
- . Childhood obesity: genetic and environmental overlap with normal-range BMI. Obesity. 2008;16:1585–1590
- . Appetite and adiposity in children: evidence for a behavioral susceptibility theory of obesity. Am J Clin Nutr. 2008;88:22–29
- Effect of the melanocortin-3 receptor C17A and G241A variants on weight loss in childhood obesity. Am J Clin Nutr. 2007;85:950–953
- Sporadic mutations in melanocortin receptor 3 in morbid obese individuals. Eur J Hum Genet. 2008;16:581–586
- . Functional characterization of novel melanocortin-3 receptor mutations identified from obese subjects. Biochim Biophys Acta. 2007;1772:1167–1174
- . Body weight is regulated by the brain: a link between feeding and emotion. Mol Psychiatry. 2005;10:132–146
- . The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R). Peptides. 2006;27:259–264
- Effects of selective modulation of the central melanocortin-3–receptor on food intake and hypothalamic POMC expression. Peptides. 2008;29:440–447
- Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 2001;411:480–484
- . Distribution of cDNA for melanocortin receptor subtypes in human tissues. Biochem Mol Biol Int. 1996;38:73–80
- The melanocortin 3 receptor is required for entrainment to meal intake. J Neurosci. 2008;28:12946–12955
- . Association between HLA-DQB1 alleles and type 1 diabetes in a case-parentsstudy conducted in Santiago, Chile. Am J of Epidemiol. 2001;153:794–798
- . A socio-genetic cline in Chilean population. Rev Med Chile. 1987;115:295–299
This study was supported by grant 1061096 from FONDECYT, Chile.
PII: S0899-9007(09)00301-3
doi: 10.1016/j.nut.2009.07.005
© 2010 Elsevier Inc. All rights reserved.
« Previous
Next »
Nutrition
Volume 26, Issue 7
, Pages 760-765
, July 2010
