Nutrition
Volume 26, Issue 6 , Pages 634-640, June 2010

High-dose selenium for critically ill patients with systemic inflammation: Pharmacokinetics and pharmacodynamics of selenious acid: A pilot study

  • William Manzanares, M.D.

      Affiliations

    • Department of Critical Care Medicine, Hospital de Clínicas Dr. Manuel Quintela, School of Medicine (University Hospital), UDELAR, Montevideo, Uruguay
    • Corresponding Author InformationCorresponding author. Tel.: +598-2-480-6180; fax: +598-2-487-7213.
    • ,
  • Alberto Biestro, M.D.

      Affiliations

    • Department of Critical Care Medicine, Hospital de Clínicas Dr. Manuel Quintela, School of Medicine (University Hospital), UDELAR, Montevideo, Uruguay
    • ,
  • Federico Galusso, M.D.

      Affiliations

    • Department of Critical Care Medicine, Hospital de Clínicas Dr. Manuel Quintela, School of Medicine (University Hospital), UDELAR, Montevideo, Uruguay
    • ,
  • María H. Torre, Ph.D.

      Affiliations

    • Department of Inorganic Chemistry, School of Chemistry, UDELAR, Montevideo, Uruguay
    • ,
  • Nelly Mañáy, Ph.D.

      Affiliations

    • Department of Toxicology, School of Chemistry, UDELAR, Montevideo, Uruguay
    • ,
  • Gianella Facchin, Ph.D.

      Affiliations

    • Department of Inorganic Chemistry, School of Chemistry, UDELAR, Montevideo, Uruguay
    • ,
  • Gil Hardy, Ph.D.

      Affiliations

    • Institute of Food, Nutrition and Human Health, Massey University, Auckland, New Zealand

Received 15 February 2009; accepted 26 June 2009. published online 18 January 2010.

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 This work was supported in part by grants from the Comisión Sectorial para la Investigación Científica (CSIC), UdeLaR, and the Fondo Clemente Estable 2004/10.072, DyCIT, Ministerio de Educación y Cultura, Uruguay.

PII: S0899-9007(09)00297-4

doi:10.1016/j.nut.2009.06.022

Nutrition
Volume 26, Issue 6 , Pages 634-640, June 2010

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