Nutrition
Volume 26, Issue 5 , Pages 551-555 , May 2010

F2-isoprostanes and total radical-trapping antioxidant potential in preterm infants receiving parenteral lipid emulsions

  • Paola Roggero, M.D., M.Sc.

      Affiliations

    • Dipartimento di Scienze Materno-Infantili, Fondazione IRCCS “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena,” Università degli Studi di Milano, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +3902-5503-2483; fax: +3902-5503-2436.
    • ,
  • Fabio Mosca, M.D.

      Affiliations

    • Dipartimento di Scienze Materno-Infantili, Fondazione IRCCS “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena,” Università degli Studi di Milano, Italy
    • ,
  • Maria Lorella Giannì, M.D.

      Affiliations

    • Dipartimento di Scienze Materno-Infantili, Fondazione IRCCS “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena,” Università degli Studi di Milano, Italy
    • ,
  • Anna Orsi, M.D.

      Affiliations

    • Dipartimento di Scienze Materno-Infantili, Fondazione IRCCS “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena,” Università degli Studi di Milano, Italy
    • ,
  • Orsola Amato, M.D.

      Affiliations

    • Dipartimento di Scienze Materno-Infantili, Fondazione IRCCS “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena,” Università degli Studi di Milano, Italy
    • ,
  • Elisabetta Migliorisi, M.D.

      Affiliations

    • Farmacia Clinica Fondazione IRCCS “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena,” University of Milan, Milan, Italy
    • ,
  • Mariangela Longini, M.D.

      Affiliations

    • Department of Pediatrics, Obstetrics, and Reproductive Medicine, University of Siena, Policlinico Le Scotte, Siena, Italy
    • ,
  • Giuseppe Buonocore, M.D.

      Affiliations

    • Department of Pediatrics, Obstetrics, and Reproductive Medicine, University of Siena, Policlinico Le Scotte, Siena, Italy

Received 11 February 2009 ,Accepted 17 June 2009.

References 

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  2. Helbock HJ, Motchnik PA, Ames BN. Toxic hydroperoxides in intravenous lipid emulsions used in preterm infants. Pediatrics. 1993;91:83–87
  3. Lehner F, Demmelmair H, Röschinger W, Decsi T, Szász M, Adamovich K, et al. Metabolic effects of intravenous LCT or MCT/LCT lipid emulsions in preterm infants. J. Lipid Res. 2006;47:404–411
  4. Sala-Vila A, Barbosa VM, Calder PC. Olive oil in parenteral nutrition. Curr Opin Clin Metab Care. 2007;10:165–174
  5. Webb AN, Hardy P, Peterkin M, Lee O, Shalley H, Croft KD, et al. Tolerability and safety of olive oil–based lipid emulsion in critically ill neonates: a blinded randomized trial. Nutrition. 2008;24:1057–1064
  6. Morrow JD, Harris TM, Roberts LJ. Noncyclooxygenase oxidative formation of a series of novel prostaglandins: analytical ramifications for measurement of eicosanoids. Anal Biochem. 1990;184:1–10
  7. Morrow JD, Roberts LJ. Mass spectrometry of prostanoids: F2-isoprostanes produced by non-cyclooxygenase free radical-catalyzed mechanism. In:  Packer L editors. Oxygen radicals in biological systems, part C. Methods in enzymology. Volume 233:San Diego: Academic Press; 1994;p. 163–179
  8. Morrow JD, Awad JA, Kato T, Takahashi K, Badr KF, Roberts LJ. Formation of novel non-cyclooxygenase–derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity: an animal model of lipid peroxidation. J Clin Invest. 1992;90:2502–2507
  9. Longmire AW, Swift LL, Roberts LJ, Awad JA, Burk RF, Morrow JD. Effect of oxygen tension on the generation of F2-isoprostanes and malondialdehyde in peroxidizing rat liver microsomes. Biochem Pharmacol 1994;47:1173–7.
  10. Morrow JD, Awad JA, Boss HJ, Blair IA, Roberts LJ. Non-cyclooxygenase–derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids. Proc Natl Acad Sci U S A. 1992;89:10721–10725
  11. Morrow JD, Roberts LJ. The isoprostanes: current knowledge and directions for future research. Biochem Pharmacol. 1996;51:1–9
  12. Delanty N, Reilly M, Pratico D, FitzGerald DJ, Lawson JA, FitzGerald GA. 8-Epi PGF2 alpha: specific analysis of an isoeicosanoid as an index of oxidant stress in vivo. Br J Clin Pharmacol. 1996;42:15–19
  13. Milne GL, Sanchez CS, Musiek ES, Morrow JD. Quantification of F2-isoprostanes as a biomarker of oxidative stress. Nat Protocols. 2007;2:221–226
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  15. Comporti M, Signorini C, Leoncini S, Buonocore G, Rossi V, Ciccoli L. Plasma f2-isoprostanes are elevated in newborns and inversely correlated to gestational age. Free Radic Biol Med. 2004;37:724–732
  16. Göbel Y, Koletzko B, Böhles HJ, Engelsberger I, Forget D, Le Brun A, et al. Parenteral fat emulsions based on olive and soybean oils: a randomized clinical trial in preterm infants. J Pediatr Gastroenterol Nutr. 2003;37:161–167
  17. Pitkänen OM, Luukkainen P, Andersson S. Attenuated lipid peroxidation in preterm infants during subsequent doses of intravenous lipids. Biol Neonate. 2004;85:184–187
  18. Van Gossum A, Shariff R, Lemoyne M, Kurian R, Jeejeebhoy K. Increased lipid peroxidation after lipid infusion as measured by breath pentane output. Am J Clin Nutr. 1988;48:1394–1399
  19. Laborie S, Lavoie JC, Pineault M. Contribution of multivitamins, air, and light in the generation of peroxides in adult and neonatal parenteral nutrition solutions. Ann Pharmacother. 2000;34:440–445
  20. Silvers KM, Sluis KB, Darlow BA, McGill F, Stocker R, Winterbourn CC. Limiting light-induced lipid peroxidation and vitamin loss in infant parenteral nutrition by adding multivitamin preparations to Intralipid. Acta Paediatr. 2001;90:242–249

PII: S0899-9007(09)00287-1

doi: 10.1016/j.nut.2009.06.018

Nutrition
Volume 26, Issue 5 , Pages 551-555 , May 2010

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