Nutrition
Volume 26, Issue 1 , Pages 120-127 , January 2010

Difructose anhydride III promotes iron absorption in the rat large intestine

Received 13 May 2008 ,Accepted 29 May 2009.

References 

  1. Bruner AB, Joffe A, Duggan AK, Casella JF, Brandt J. Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls. Lancet. 1996;348:992–996
  2. Kwik-Uribe CL, Golub MS, Keen CL. Chronic marginal iron intakes during early development in mice alter brain iron concentrations and behavior despite postnatal iron supplementation. J Nutr. 2000;130:2040–2048
  3. Suzuki T, Hara H, Kasai T, Tomita F. Effects of difructose anhydride III on calcium absorption in small and large intestines of rats. Biosci Biotechnol Biochem. 1998;62:837–841
  4. Tomita K, Shiomi T, Okuhara Y, Tamura A, Shigematsu N, Hara H. Ingestion of difructose anhydride III enhances absorption and retention of calcium in healthy men. Biosci Biotechnol Biochem. 2007;71:681–687
  5. Afsana K, Shiga K, Ishizuka S, Hara H. Ingestion of an indigestible saccharide, difructose anhydride III, partially prevents the tannic acid-induced suppression of iron absorption in rats. J Nutr. 2003;133:3553–3560
  6. Asvarujanon P, Ishizuka S, Hara H. Promotive effects of non-digestible disaccharides on rat mineral absorption depend on the type of saccharide. Nutrition. 2005;21:1025–1035
  7. Shiga K, Nishimukai M, Tomita F, Hara H. Ingestion of difructose anhydride III, a non-digestible disaccharide, prevents gastrectomy-induced iron malabsorption and anemia in rats. Nutrition. 2006;22:786–793
  8. Tamura A, Shiomi T, Shigematsu N, Tomita F, Hara H. Evidence suggesting that difructose anhydride III is an indigestible and low fermentable sugar during the early stages after ingestion in humans. J Nutr Sci Vitaminol. 2003;49:422–427
  9. Tamura A, Shiomi T, Tamaki N, Shigematsu N, Tomita F, Hara H. Comparative effect of repeated ingestion of difructose anhydride III and palatinose on the induction of gastrointestinal symptoms in humans. Biosci Biotechnol Biochem. 2004;68:1882–1887
  10. Mineo H, Hara H, Tomita F. Short-chain fatty acids enhance diffusional Ca transport in the epithelium of the rat cecum and colon. Life Sci. 2001;69:517–526
  11. Mineo H, Hara H, Kikuchi H, Sakurai H, Tomita F. Various indigestible saccharides enhance net calcium transport from the epithelium of the small and large intestine of rats in vitro. J Nutr. 2001;131:3243–3246
  12. Mitamura R, Hara H, Aoyama Y, Chiji H. Supplemental feeding of difructose anhydride III restores calcium absorption impaired by ovariectomy in rats. J Nutr. 2002;132:3387–3393
  13. Ohta A, Ohtsuki M, Baba S, Adachi T, Sakata T, Sakaguchi E. Calcium and magnesium absorption from the colon and rectum are increased in rats fed fructooligosaccharides. J Nutr. 1995;125:2417–2424
  14. Demigné C, Rémésy C. Stimulation of absorption of volatile fatty acids and minerals in the cecum of rats adapted to a very high fiber diet. J Nutr. 1985;115:53–60
  15. Younes H, Demigné C, Rémésy C. Acidic fermentation in the caecum increases absorption of calcium and magnesium in the large intestine of the rat. Br J Nutr. 1996;75:301–314
  16. Hara H, Nagata M, Ohta A, Kasai T. Increases in calcium absorption with ingestion of soluble dietary fibre, guar-gum hydrolysate, depend on the caecum in partially nephrectomized and normal rats. Br J Nutr. 1996;76:773–784
  17. Trinidad TP, Wolever TM, Thompson LU. Effect of acetate and propionate on calcium absorption from the rectum and distal colon of humans. Am J Clin Nutr. 1996;63:574–578
  18. Mineo H, Amano M, Chiji H, Shigematsu N, Tomita F, Hara H. Absorptive activity of calcium in the isolated cecal epithelium adaptively increased by 2 week's feeding of difructose anhydride III in rats. Biosci Biotechnol Biochem. 2003;67:1847–1851
  19. Hoshi S, Sakata T, Mikuni K, Hashimoto H, Kimura S. Galactosylsucrose and xylosylfructoside alter digestive tract size and concentrations of cecal organic acids in rats fed diets containing cholesterol and cholic acid. J Nutr. 1994;124:52–60
  20. Hayashi K, Hara H, Asvarujanon P, Aoyama Y, Luangpituksa P. Ingestion of insoluble dietary fibre increased zinc and iron absorption and restored growth rate and zinc absorption suppressed by dietary phytate in rats. Br J Nutr. 2001;86:443–451
  21. Hubert N, Hentze MW. Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc Natl Acad Sci U S A. 2002;99:12345–12350
  22. Mineo H, Hara H, Shigematsu N, Okuhara Y, Tomita F. Melibiose, difructose anhydride III and difructose anhydride IV enhance net calcium absorption in rat small and large intestinal epithelium by increasing the passage of tight junctions in vitro. J Nutr. 2002;132:3394–3399
  23. Suzuki T, Hara H. Various nondigestible saccharides open a paracellular calcium transport pathway with the induction of intracellular calcium signaling in human intestinal Caco-2 cells. J Nutr. 2004;134:1935–1941
  24. Minamida K, Ohashi M, Hara H, Asano K, Tomita F. Effects of ingestion of difructose anhydride III (DFA III) and the DFA III-assimilating bacterium ruminococcus productus on rat intestine. Biosci Biotech Biochem. 2006;70:332–339
  25. Mineo H, Amano M, Minaminida K, Chiji H, Shigematsu N, Tomita F, et al. Two-week feeding of difructose anhydride III enhances calcium absorptive activity with epithelial cell proliferation in isolated rat cecal mucosa. Nutrition. 2006;22:312–320
  26. Roediger WE, Rae DA. Trophic effect of short chain fatty acids on mucosal handling of ions by the defunctioned colon. Br J Surg. 1982;69:23–25
  27. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 1997;388:482–488
  28. Mackenzie B, Takanaga H, Hubert N, Rolfs A, Hediger MA. Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1). Biochem J. 2007;403:59–69
  29. Ohta A, Ohtsuki M, Baba S, Takizawa T, Adachi T, Kimura S. Effects of fructooligosaccharides on the absorption of iron, calcium and magnesium in iron-deficient anemic rats. J Nutr Sci Vitaminol. 1995;41:281–291
  30. Sakai K, Ohta A, Shiga K, Takasaki M, Tokunaga T, Hara H. The cecum and dietary short-chain fructooligosaccharides are involved in preventing postgastrectomy anemia in rats. J Nutr. 2000;130:1608–1612
  31. Kim M, Atallah MT, Amarasiriwardena C, Barnes R. Pectin with low molecular weight and high degree of esterification increases absorption of 58Fe in growing rats. J Nutr. 1996;126:1883–1890

PII: S0899-9007(09)00243-3

doi: 10.1016/j.nut.2009.05.024

Nutrition
Volume 26, Issue 1 , Pages 120-127 , January 2010