Nutrition
Volume 26, Issue 4 , Pages 449-458 , April 2010

Erythritol is a sweet antioxidant

  • Gertjan J.M. den Hartog, Ph.D.

      Affiliations

    • Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31-43-388-2916; fax: +31-43-388-4149.
  • ,
  • Agnes W. Boots, Ph.D.

      Affiliations

    • Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
  • ,
  • Aline Adam-Perrot, Ph.D.

      Affiliations

    • Cargill R&D Center Europe, Vilvoorde, Belgium
    • Current address: Tate & Lyle Ingredients France, Villeneuve d'Ascq, France.
  • ,
  • Fred Brouns, Ph.D.

      Affiliations

    • Department of Human Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
  • ,
  • Inge W.C.M. Verkooijen, M.Sc.

      Affiliations

    • Clinical Trial Center Maastricht, Maastricht, The Netherlands
  • ,
  • Antje R. Weseler, Ph.D.

      Affiliations

    • Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
  • ,
  • Guido R.M.M. Haenen, Ph.D.

      Affiliations

    • Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
  • ,
  • Aalt Bast, Ph.D.

      Affiliations

    • Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands

Received 21 November 2008 ,Accepted 13 May 2009.

References 

  1. Gil-del Valle L, C Milian L de la, Toledo A, Vilaró N, Tápanes R, Otero MA. Altered redox status in patients with diabetes mellitus type I. Pharmacol Res. 2005;51:375–380
  2. Assaloni R, Da Ros R, Quagliaro L, Piconi L, Maier A, Zuodar G, et al. Effects of S21403 (mitiglinide) on postprandial generation of oxidative stress and inflammation in type 2 diabetic patients. Diabetologia. 2005;48:1919–1924
  3. West IC. Radicals and oxidative stress in diabetes. Diabet Med. 2000;17:171–180
  4. Yoshida K, Hirokawa J, Tagami S, Kawakami Y, Urata Y, Kondo T. Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: regulation of glutathione synthesis and efflux. Diabetologia. 1995;38:201–210
  5. Goossens J, Röper H. Erythritol: a new bulk sweetener. Int Food Ingred. 1994;1–2:27–33
  6. Bernt WO, Borzelleca JF, Flamm G, Munro IC. Erythritol: a review of biological and toxicological studies. Regul Toxicol Pharmacol. 1996;24:S191–S197
  7. Munro IC, Berndt WO, Borzelleca JF, Flamm G, Lynch BS, Kennepohl E, et al. Erythritol: an interpretive summary of biochemical, metabolic, toxicological and clinical data. Food Chem Toxicol. 1998;36:1139–1174
  8. Ching TL, Haenen GR, Bast A. Cimetidine and other H2 receptor antagonists as powerful hydroxyl radical scavengers. Chem Biol Interact. 1993;86:119–127
  9. Li S, Patapoff TW, Nguyen TH, Borchardt RT. Inhibitory effect of sugars and polyols on the metal-catalyzed oxidation of human relaxin. J Pharm Sci. 1996;85:868–872
  10. Livesey G. Health potential of polyols as sugar replacers, with emphasis on low glycaemic properties. Nutr Res Rev. 2003;16:163–191
  11. Halliwell B, Gutteridge JMC, Aruoma OI. The deoxyribose method: a simple ‘test-tube’ assay for determination of rate constants for reactions of hydroxyl radicals. Anal Biochem. 1987;165:215–219
  12. Kirkova M, Atanassova M, Russanov E. Effects of cimetidine and its metal complexes on nitroblue tetrazolium and ferricytochrome c reduction by superoxide radicals. Gen Pharmacol. 1999;33:271–276
  13. Vosters O, Nève J. Inhibitory effects of thiol-containing drugs on erythrocyte oxidative damages investigated with an improved assay system. Talanta. 2002;57:595–600
  14. Nascimento RF, Marques JC, Lima Neto BS, De Keukeleire D, Franco DW. Qualitative and quantitative high-performance liquid chromatographic analysis of aldehydes in Brazilian sugar cane spirits and other distilled alcoholic beverages. J Chromatogr A. 1997;782:13–23
  15. Hasselbaink DM, Glatz JFC, Luiken JJFP, Roemen THM, van der Vusse GJ. Ketone bodies disturb fatty acid handling in isolated cardiomyocytes derived from control and diabetic rats. Biochem J. 2003;371:753–760
  16. Baker MA, Cerniglia GJ, Zaman A. Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples. Anal Biochem. 1990;190:360–365
  17. Vandeputte C, Guizon I, Genestie-Denis I, Vannier B, Lorenzon G. A microtiter plate assay for total glutathione and glutathione disulfide contents in cultured/isolated cells: performance study of a new miniaturized protocol. Cell Biol Toxicol. 1994;10:415–421
  18. Arts MJ, Haenen GR, Voss HP, Bast A. Antioxidant capacity of reaction products limits the applicability of the Trolox Equivalent Antioxidant Capacity (TEAC) assay. Food Chem Toxicol. 2004;42:45–49
  19. Lepage G, Munoz G, Champagne J, Roy CC. Preparative steps necessary for the accurate measurement of malondialdehyde by high-performance liquid chromatography. Anal Biochem. 1991;197:277–283
  20. Buettner GR. Spin trapping: ESR parameters of spin adducts. Free Radic Biol Med. 1987;3:259–303
  21. van Acker SABE, van den Berg DJ, Tromp MN, Griffioen DH, van Bennekom WP, van der Vijgh WJF, et al. Structural aspects of antioxidant activity of flavonoids. Free Radic Biol Med. 1996;20:331–342
  22. Schuchmann MN, Von Sonntag C. Radiation chemistry of carbohydrates. Part 14. Hydroxyl radical induced oxidation of D-glucose in oxygenated aqueous solution. J Chem Soc Perkins Trans II. 1977;2:1958–1963
  23. Cherqaoui A, Takki D, Kokoh KB, Hahn F, Belgsir EM, Léger J-M, et al. Electro-oxidation of meso-erythritol on platinum in acid medium: analysis of the reaction products. J Electroanalyt Chem. 1999;464:101–109
  24. Yokozawa T, Kim HY, Cho EJ. Erythritol attenuates the diabetic oxidative stress through glucose metabolism and lipid peroxidation in streptozotocin-induced diabetic rats. J Agric Food Chem. 2002;50:5485–5489
  25. Gross ER, LaDisa JF, Weihrauch D, Olson LE, Kress TT, Hettrick DA, et al. Reactive oxygen species modulate coronary wall shear stress and endothelial function during hyperglycemia. Am J Physiol Heart Circ Physiol. 2003;284:H1552–H1559
  26. Widlansky ME, Gokce N, Keany JF, Vita JA. The clinical implications of endothelial dysfunction. J Am Coll Cardiol. 2003;42:1149–1160
  27. Praticò D. Antioxidants and endothelium protection. Atherosclerosis. 2005;181:215–224
  28. Leighton F, Miranda-Rottmann S, Urquiaga I. A central role of eNOS in the protective effect of wine against metabolic syndrome. Cell Biochem Funct. 2006;24:291–298
  29. Halcox JP, Schenke WH, Zalos G, Mincemoyer R, Prasad A, Waclawiw MA, et al. Prognostic value of coronary vascular endothelial dysfunction. Circulation. 2002;6:653–658
  30. Dhein S, Kabat A, Olbrich A, Rosen P, Schroder H, Mohr FW. Effect of chronic treatment with vitamin E on endothelial dysfunction in a type I in vivo diabetes mellitus model and in vitro. J Pharmacol Exp Ther. 2003;305:114–122
  31. Wang X, Quinn PJ. Vitamin E and its function in membranes. Prog Lipid Res. 1999;38:309–336
  32. Ceriello A. New insights on oxidative stress and diabetic complications may lead to a “causal” antioxidant therapy. Diabetes Care. 2003;26:1589–1596
  33. Pennathur S, Wagner JD, Leeuwenburgh C, Litwak KN, Heinecke JW. A hydroxyl radical-like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular disease. J Clin Invest. 2001;107:853–860
  34. Goris RJA. Treatment of reflex sympathetic dystrophy with hydroxyl radical scavengers. Unfallchirurg. 1985;88:330–332
  35. Matsushima H, Yonemura K, Ohishi K, Hishida A. The role of oxygen free radicals in cisplatin-induced acute renal failure in rats. J Lab Clin Med. 1998;131:518–526
  36. Meijer EP, Coolen SA, Bast A, Westerterp KR. Exercise-induced oxidative stress in older adults as measure by antipyrine oxidation. Metabolism. 2001;50:1484–1488

PII: S0899-9007(09)00227-5

doi: 10.1016/j.nut.2009.05.004

Nutrition
Volume 26, Issue 4 , Pages 449-458 , April 2010