Micronutrients and lifestyles in Taiwanese patients with stage 3 to 5 chronic kidney disease
Received 16 November 2008; accepted 25 April 2009. published online 12 October 2009.
Abstract
Objective
Lycopene is an antioxidant that reduces oxidative stress. Analgesics are commonly used and may impair kidney function. However, the associations among plasma lycopene, analgesic use, and chronic kidney disease (CKD) are unknown. A hospital-based, case–control study was conducted to determine the association among plasma lycopene, analgesic use, and CKD.
Methods
Two hundred one patients with CKD and 313 controls were recruited, and CKD was defined as an estimated glomerular filtration rate <60mL/min per 1.73m2, as calculated by the Modification of Diet in Renal Disease formula. Plasma antioxidants were measured by high-performance liquid chromatography.
Results
This study showed that the higher the plasma lycopene was, the lower the CKD risk. Specifically, in subjects with a plasma lycopene level ≥17.97 or 7.72–17.97μg/dL, the adjusted odds ratio of CKD was 0.32 (95% confidence interval 0.18–0.58) or 0.49 (95% confidence interval 0.29–0.83), respectively, compared with subjects with a plasma lycopene level <7.72μg/dL, independent of age, gender, level of education, paternal and maternal ethnicities, cigarette smoking, analgesic use, hypertension, and diabetes history. In contrast, the higher the plasma retinol level, the higher the risk of CKD. A significantly higher risk was demonstrated in analgesic users than in non-users (odds ratio 3.83, 95% confidence interval 1.75–8.40), but a significantly lower risk was shown in subjects who used analgesics on an as-needed basis than in non-users. Plasma lycopene tended to interact additively with analgesic consumption in modifying the CKD risk; however, the interactions were statistically insignificant.
Conclusion
This is the first study showing that a low plasma lycopene level is associated with CKD risk.
aDepartment of Internal Medicine/Nephrology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
bSchool of Public Health, Taipei Medical University, Taipei, Taiwan
cDepartment of Chinese Medicine, Chang Gung Memorial Hospital, and Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
dNephrology Division, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
eDepartment of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan
fDepartment of Public Health, School of Medicine, Taipei Medical University, Taipei, Taiwan
ABSTRACT