Nutrition
Volume 26, Issue 3 , Pages 321-330 , March 2010

Hypocholesterolemic effects of Lactobacillus plantarum KCTC3928 by increased bile acid excretion in C57BL/6 mice

  • Jungae Jeun, Ph.D.

      Affiliations

    • Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Institute of Biomedical Sciences and Food Safety, Korea University, Seoul, South Korea
    • ,
  • Sukyung Kim, M.Sc.

      Affiliations

    • Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Institute of Biomedical Sciences and Food Safety, Korea University, Seoul, South Korea
    • ,
  • Sung-Yun Cho, B.Sc.

      Affiliations

    • Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Institute of Biomedical Sciences and Food Safety, Korea University, Seoul, South Korea
    • ,
  • Hee-jin Jun, M.Sc.

      Affiliations

    • Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Institute of Biomedical Sciences and Food Safety, Korea University, Seoul, South Korea
    • ,
  • Hyun-Jin Park, Ph.D.

      Affiliations

    • Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Institute of Biomedical Sciences and Food Safety, Korea University, Seoul, South Korea
    • ,
  • Jae-Gu Seo, Ph.D.

      Affiliations

    • R&D Center of Cellbiotech Co. Ltd., Gyunggi-Do, South Korea
    • ,
  • Myung-Jun Chung, Ph.D.

      Affiliations

    • R&D Center of Cellbiotech Co. Ltd., Gyunggi-Do, South Korea
    • ,
  • Sung-Joon Lee, Ph.D.

      Affiliations

    • Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Institute of Biomedical Sciences and Food Safety, Korea University, Seoul, South Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82-2-3290-3029; fax: +82-2-3290-3494.

Received 13 November 2008 ,Accepted 17 April 2009.

References 

  1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362(6423):801–809
  2. Lora KR, Morse KL, Gonzalez-Kruger GE, Driskell JA. High saturated fat and cholesterol intakes and abnormal plasma lipid concentrations observed in a group of 4- to 8-year-old children of Latino immigrants in rural Nebraska. Nutr Res. 2007;27:483–491
  3. Jiménez JPe, Serrano J, Tabernero M, Arranz S, Díaz-Rubio ME, Garcia-Diz L, et al. Effects of grape antioxidant dietary fiber in cardiovascular disease risk factors. Nutrition. 2008;24:646–653
  4. Theuwissen E, Mensink RP. Water-soluble dietary fibers and cardiovascular disease. Physiol Behav. 2008;94:285–292
  5. Akalin AS, Gonc S, Duzel S. Influence of yogurt and acidophilus yogurt on serum cholesterol levels in mice. J Dairy Sci. 1997;80:2721–2725
  6. Danielson AD, Peo ER, Shahani KM, Lewis AJ, Whalen PJ, Amer MA. Anticholesteremic property of Lactobacillus acidophilus yogurt fed to mature boars. J Anim Sci. 1989;67:966–974
  7. Schaafsma G, Meuling WJ, van Dokkum W, Bouley C. Effects of a milk product, fermented by Lactobacillus acidophilus and with fructo-oligosaccharides added, on blood lipids in male volunteers. Eur J Clin Nutr. 1998;52:436–440
  8. Brown MS, Goldstein JL. Lowering plasma cholesterol by raising LDL receptors. Atheroscler Suppl. 2004;5:57–59
  9. Han S-H, Chung MJ, Lee S-J, Rhee C. Digestion-resistant fraction from soybean [Glycine max (L.) Merrill] induces hepatic LDL receptor and CYP7A1 expression in apolipoprotein E–deficient mice. J Nutr Biochem. 2006;17:682–688
  10. Slim H, Thompson PD. Ezetimibe-related myopathy: a systematic review. J Clin Lipidol. 2008;2:328–334
  11. Srivastava A, Pandey SN, Choudhuri G, Mittal B. Role of genetic variant A-204C of cholesterol 7[alpha]-hydroxylase (CYP7A1) in susceptibility to gallbladder cancer. Mol Genet Metab. 2008;94:83–89
  12. Kaburagi T, Yamano T, Fukushima Y, Yoshino H, Sato K. Effect of Lactobacillus johnsonii La1 on immune function and serum albumin in aged and malnourished aged mice. Nutrition. 2007;23:342–350
  13. Yadav H, Jain S, Sinha PR. Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats. Nutrition. 2007;23:62–68
  14. Pereira DIA, Gibson GR. Effects of consumption of probiotics and prebiotics on serum lipid levels in humans. Crit Rev Biochem Mol Biol. 2002;37:259–281
  15. Simons LA, Amansec SG, Conway P. Effect of Lactobacillus fermentum on serum lipids in subjects with elevated serum cholesterol. Nutr Metab Cardiovasc Dis. 2006;16:531–535
  16. Kim H-K, Park J-Y, Lee GG, Kim JH. Isolation of a bacteriocin-producing Lactobacillus plantarum strain from kimchi. Food Sci Biotechnol. 2003;11:166–170
  17. Lee J-H, Kweon D-H, Lee S-C. Isolation and characterization of an immunopotentiating factor from Lactobacillus plantarum in kimchi: assessment of immunostimulatory activities. Food Sci Biotechnol. 2006;15:877–883
  18. Lee J-Y, Kim C-J, Kunz B. Identification of lactic acid bacteria isolated from kimchi and studies on their suitability for application as starter culture in the production of fermented sausages. Meat Sci. 2006;72:437–445
  19. Tamang JP, Sarkar PK. Microbiology of mesu, a traditional fermented bamboo shoot product. Int J Food Microbiol. 1996;29:49–58
  20. Stecchini ML, Sarais I, Bertoldi Md. The influence of Lactobacillus plantarum culture inoculation on the fate of Staphylococcus aureus and Salmonella typhimurium in Montasio cheese. Int J Food Microbiol. 1991;14:99–109
  21. De Smet I, Van Hoorde L, De Saeyer M, Vande WM, Verstraete W. In vitro study of bile salt hydrolase (bsh) activity of bsh isogenic Lactobacillus plantarum 80 strains and estimation of cholesterol lowering through enhanced bsh activity. Microb Ecol Health Dis. 1994;7:315–329
  22. Chung MJ, Cho YJ, Kim SD, Hong UP. Manufacture method protein coating-lactic acid bacteria. Seoul, Korea, KIPRIS, KR10-0429495; 2002, p. 1–15.
  23. Chung MJ, Cho YJ, Kim SD, Hong UP. Lactic acid bacteria powder double-coated using protein and polysaccharide and method preparing the same and a dosage from thereof. EU1514553; 2008, p. 1–20.
  24. Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol. 1957;28:56–63
  25. Fausa O, Skålhegg BA. Quantitative determination of bile acids and their conjugates using thin-layer chromatography and a purified 3-hydroxysteroid dehydrogenase. Scand J Gastroenterol. 1974;9:249–254
  26. Chul-Gyu H, Jin-Kook C, Chi-Ho L, Young-Gyu C, Young-Ae H, Shang-Hun S. Cholesterol lowering effect of Lactobacillus plantarum isolated from human feces. J Microbiol Biotechnol. 2006;16:1201–1209
  27. Naruszewicz M, Johansson M-L, Zapolska-Downar D, Bukowska H. Effect of Lactobacillus plantarum 299v on cardiovascular disease risk factors in smokers. Am J Clin Nutr. 2002;76:1249–1255
  28. Chung MJ, Park KW, Kim KH, Kim C-T, Baek JP, Bang K-H, et al. Asian plantain (Plantago asiatica) essential oils suppress 3-hydroxy-3-methyl-glutaryl-co-enzyme A reductase expression in vitro and in vivo and show hypocholesterolaemic properties in mice. Br J Nutr. 2008;99:67–75
  29. Fuchs D, Berges C, Opelz G, Daniel V, Naujokat C. HMG-CoA reductase inhibitor simvastatin overcomes bortezomib-induced apoptosis resistance by disrupting a geranylgeranyl pyrophosphate-dependent survival pathway. Biochem Biophys Res Commun. 2008;374:309–314
  30. Mokashi V, Singh DK, Porter TD. Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro. Arch Biochem Biophys. 2005;433:474–480
  31. Osborne TF, Goldstein JL, Brown MS. 5′ end of HMG CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcription. Cell. 1985;42:203–212
  32. Raju J, Bird RP. Diosgenin, a naturally occurring furostanol saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells. Cancer Lett. 2007;255:194–204
  33. Valesky RJ, Liu L, Musson DG, Zhao JJ. Automated enzyme inhibition assay method for the determination of atorvastatin-derived HMG-CoA reductase inhibitors in human plasma using radioactivity detection. J Pharmacol Toxicol Methods. 2008;57:61–69
  34. Xu L, Simoni RD. The inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by sterol regulatory element binding protein cleavage-activating protein requires four phenylalanine residues in span 6 of HMG-CoA reductase transmembrane domain. Arch Biochem Biophys. 2003;414:232–243
  35. Ballantyne CM. Low-density lipoproteins and risk for coronary artery disease. Am J Cardiol. 1998;82(suppl 2):3–12
  36. Levine GN, Keaney JF, Vita JA. Cholesterol reduction in cardiovascular disease—clinical benefits and possible mechanisms. N Engl J Med. 1995;332:512–521
  37. Abrahamsson A, Gustafsson U, Ellis E, Nilsson L-M, Sahlin S, Björkhem I, et al. Feedback regulation of bile acid synthesis in human liver: Importance of HNF-4[alpha] for regulation of CYP7A1. Biochem Biophys Res Comm. 2005;330:395–399
  38. Ando H, Tsuruoka S, Yamamoto H, Takamura T, Kaneko S, Fujimura A. Regulation of cholesterol 7[alpha]-hydroxylase mRNA expression in C57BL/6 mice fed an atherogenic diet. Atherosclerosis. 2005;178:265–269
  39. Chen W, Suruga K, Nishimura N, Gouda T, Lam VN, Yokogoshi H. Comparative regulation of major enzymes in the bile acid biosynthesis pathway by cholesterol, cholate and taurine in mice and rats. Life Sci. 2005;77:746–757
  40. Maler L, Sporst M, Juvet LK, Mousavi SA, Gjøen T, Berg T, et al. Bile acids reduce SR-BI expression in hepatocytes by a pathway involving FXR/RXR, SHP, and LRH-1. Biochem Biophys Res Comm. 2005;336:1096–1105
  41. Fukushima M, Yamada A, Endo T, Nakano M. Effects of a mixture of organisms, Lactobacillus acidophilus or Streptococcus faecalis on [delta]6-desaturase activity in the livers of rats fed a fat- and cholesterol-enriched diet. Nutrition. 1999;15:373–378
  42. Jahreis G, Vogelsang H, Kiessling G, Schubert R, Bunte C, Hammes WP. Influence of probiotic sausage (Lactobacillus paracasei) on blood lipids and immunological parameters of healthy volunteers. Food Res Int. 2002;35:133–138
  43. Nguyen TDT, Kang JH, Lee MS. Characterization of Lactobacillus plantarum PH04, a potential probiotic bacterium with cholesterol-lowering effects. Int J Food Microbiol. 2007;113:358–361
  44. Tamai Y, Yoshimitsu N, Watanabe Y, Kuwabara Y, Nagai S. Effects of milk fermented by culturing with various lactic acid bacteria and a yeast on serum cholesterol level in rats. J Ferment Bioeng. 1996;81:181–182
  45. Liong MT, Shah NP. Bile salt deconjugation ability, bile salt hydrolase activity and cholesterol co-precipitation ability of lactobacilli strains. Int Dairy J. 2005;15:391–398
  46. Liong MT, Shah NP. Bile salt deconjugation and BSH activity of five bifidobacterial strains and their cholesterol co-precipitating properties. Food Res Int. 2005;38:135–142
  47. Smet ID, Hoorde LV, Woestyne MV, Christiaens H, Verstraete W. Significance of bile salt hydrolytic activities of lactobacilli. J Appl Bacteriol. 1995;79:292–301

 This work was supported by grant A050376 from the Korean Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea.

PII: S0899-9007(09)00192-0

doi: 10.1016/j.nut.2009.04.011

Nutrition
Volume 26, Issue 3 , Pages 321-330 , March 2010

Article Tools

* Image Usage & Resolution