Nutrition
Volume 25, Issue 10 , Pages 1006-1010 , October 2009

Two cases of severe hypoalbuminemia (<10 g/L)

  • Annalise E. Zemlin, M.B.Ch.B., F.C.Path., M.Med.

      Affiliations

    • Department of Chemical Pathology, National Health Laboratory Service, Tygerberg Hospital, Stellenbosch University, Parow, South Africa
    • Department of Chemical Pathology, National Health Laboratory Service, Green Point Complex, Green Point, South Africa
    • Corresponding Author InformationCorresponding author. Tel.: +27-21-938-4254; fax: +27-21-938-4640.
    • ,
  • Lesley J. Burgess, M.B.B.Ch., M.Med., Ph.D.

      Affiliations

    • TREAD Research/Cardiology Unit, Department of Internal Medicine, Tygerberg Hospital, Stellenbosch University, Parow, South Africa
    • ,
  • Andries Engelbrecht, Nat.Dip.Med.Tech., N.H.D.

      Affiliations

    • Department of Chemical Pathology, National Health Laboratory Service, Green Point Complex, Green Point, South Africa

Received 7 May 2008 ,Accepted 28 December 2008.

References 

  1. Prinsen BHCMT, de Sain-van der Velden MGM. Albumin turnover: experimental approach and its application in health and renal diseases. Clin Chim Acta. 2004;347:1–14
  2. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999;340:448–454
  3. Bar-Or D, Rael LT, Bar-Or R, Slone SS, Craun M. The formation and rapid clearance of a truncated albumin species in a critically ill patient. Clin Chim Acta. 2006;365:346–349
  4. Koay ESC, Walmesley N. A primer of chemical pathology. 1st ed. Singapore: World Scientific; 1996;
  5. Ballmer PE. Causes and mechanisms of hypoalbuminaemia. Clin Nutr. 2001;20:271–273
  6. Lyon AW, Meinert P, Bruce GA, Laxdal VA, Salkie ML. Influence of methodology on the detection and diagnosis of congenital analbuminaemia. Clin Chem. 1998;44:2365–2367
  7. Watanabe A. Why albumin now? Let's think about albumin measurement methods, the definition of hypoalbuminaemia, and microheterogeneity. Nutrition. 2005;21:1156–1157
  8. Beckman Synchron CX Systems Chemistry Information Sheet, Brea, CA. Beckman Coulter, 2007.
  9. Franch-Arcas G. The meaning of hypoalbuminaemia in clinical practice. Clin Nutr. 2001;20:265–269
  10. Rhoads JE, Alexander CE. Nutritional problems of surgical patients. Ann N Y Acad Sci. 1955;63:268–275
  11. Phillils A, Shaper AG, Whincup PH. Association between serum albumin and mortality from cardiovascular disease, cancer and other causes. Lancet. 1989;2:1434–1436
  12. Chojnowska E. Serum albumin concentration is not a marker of nutritional status (letter). BMJ. 1996;313:230
  13. dos Santos NSJ, Draibe SA, Kamimura MA, Canziani MEF, Cendoroglo M, Junior AG, et al. Is serum albumin a marker of nutritional status in hemodialysis patients without evidence of inflammation?. Artif Organs. 2003;27:681–686
  14. Klein S. The myth of serum albumin as a measure of nutritional status. Gastroenterology. 1990;99:1845–1851
  15. Fuoco U, Scivoletto G, Pace A, Vuno VU, Castellano V. Anaemia and serum protein alteration in patients with pressure ulcers. Spinal Cord. 1997;35:58–60
  16. Scivoletto G, Fuoco U, Morganti B, Cosentino E, Molinari M. Pressure sores and blood and serum dysmetabolism in spinal cord injury patients. Spinal Cord. 2004;42:473–476
  17. The SAFE Study Investigators . A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med. 2004;350:2247–2256
  18. Petersen SR, Jeevanandam M, Shahbazian LM, Holaday NJ. Reprioritization of liver protein synthesis resulting from recombinant human growth hormone supplementation in parenterally fed trauma patients: the effect of growth hormone on the acute phase response. J Trauma. 1997;42:987–995
  19. Dahn MS, Mitchell RA, Lange P, Smith S, Jacobs L. Hepatic metabolic response to injury and sepsis. Surgery. 1995;117:520–530
  20. Jahoor F, Wykes L, del Rosario M, Frazer M, Reeds PJ. Chronic protein undernutrition and an acute inflammatory stimulus elicit different protein kinetic responses in plasma but not in muscle of piglets. J Nutr. 1999;129:693–699
  21. Fearon KC, Falconer JS, Slater C, Mcmillan DC, Ross JA, Preston T. Albumin synthesis rates are not decreased in hypoalbuminaemic cachectic cancer patients with an ongoing acute-phase protein response. Ann Surg. 1998;227:249–254
  22. Barle H, Januszkiewicz A, Hallstrom L, Essen P, McNurlan MA, Garlick PJ. Albumin synthesis in humans increases immediately following the administration of endotoxin. Clin Sci (Lond). 2002;103:525–531
  23. Brook MG, Miller RF. HIV associated nephropathy: a treatable condition. Sex Transm Inf. 2001;77:97–100
  24. Jahoor F, Abramson S, Heird WC. The protein metabolic response to HIV infection in young children. Am J Clin Nutr. 2003;78:182–189

PII: S0899-9007(09)00117-8

doi: 10.1016/j.nut.2008.12.017

Nutrition
Volume 25, Issue 10 , Pages 1006-1010 , October 2009

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