Nutrition
Volume 25, Issue 10 , Pages 1011-1019 , October 2009

Higher dietary intake of long-chain ω-3 polyunsaturated fatty acids is inversely associated with depressive symptoms in women

  • Laura A. Colangelo, M.S.

      Affiliations

    • Department of Preventive Medicine, Feinberg School of Medicine, Chicago, Illinois, USA
    • Corresponding Author InformationCorresponding author. Tel.: + 312-908-1971; fax: + 312-908-9588.
    • ,
  • Ka He, M.D., Sc.D.

      Affiliations

    • Departments of Nutrition and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    • ,
  • Mary A. Whooley, M.D.

      Affiliations

    • Department of Veterans Affairs Medical Center and Departments of Medicine, Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA
    • ,
  • Martha L. Daviglus, M.D., Ph.D.

      Affiliations

    • Department of Preventive Medicine, Feinberg School of Medicine, Chicago, Illinois, USA
    • ,
  • Kiang Liu, Ph.D.

      Affiliations

    • Department of Preventive Medicine, Feinberg School of Medicine, Chicago, Illinois, USA

Received 14 September 2008 ,Accepted 27 December 2008.

References 

  1. Salem N, Litman B, Kim HY, Gawrisch K. Mechanisms of action of docosahexaenoic acid in the nervous system. Lipids. 2001;36:945–959
  2. Moriguchi T, Greiner RS, Salem N. Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration. J Neurochem. 2000;75:2563–2573
  3. Das UN. Long-chain polyunsaturated fatty acids in the growth and development of the brain and memory. Nutrition. 2003;19:62–65
  4. Salem N, Wegher B, Mena P, Uauy R. Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants. Proc Natl Acad Sci U S A. 1996;93:49–54
  5. Smith RS. The macrophage theory of depression. Med Hypotheses. 1991;35:298–306
  6. Hibbeln JR, Salem N. Dietary polyunsaturated fatty acids and depression: when cholesterol does not satisfy. Am J Clin Nutr. 1995;62:1–9
  7. Hibbeln JR. Fish consumption and major depression (letter). Lancet. 1998;351:1213
  8. Hibbeln JR. Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysis. J Affect Disord. 2002;69:15–29
  9. Peet M, Murphy B, Shay J, Horrobin D. Depletion of omega-3 fatty acid levels in red blood cell membranes of depressive patients. Biol Psychiatry. 1998;43:315–319
  10. Edwards R, Peet M, Shay J, Horrobin D. Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. J Affect Disord. 1998;48:149–155
  11. Maes M, Christophe A, Delanghe J, Altamura C, Neels H, Melzer HY. Lowered ω3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients. Psychiatry Res. 1999;85:275–291
  12. Tiemeier H, van Tuijl HR, Hofman A, Kiliaan AJ, Breteler MMB. Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study. Am J Clin Nutr. 2003;78:40–46
  13. Tanskanen A, Hibbeln JR, Tuomilehto J, Uutela A, Haukkala A, Viinamäki H, et al. Fish consumption and depressive symptoms in the general population in Finland. Psychiatr Serv. 2001;52:529–531
  14. Timonen M, Horrobin D, Jokelainen J, Laitinen J, Herva A, Räsänen P. Fish consumption and depression: the Northern Finland 1966 birth cohort study. J Affect Disord. 2004;82:447–452
  15. Nemets B, Stahl Z, Belmaker RH. Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. Am J Psychiatry. 2002;159:477–479
  16. Peet M, Horrobin DF. A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs. Arch Gen Psychiatry. 2002;59:913–919
  17. Su K-P, Huang S-Y, Chiu C-C, Shen WW. Omega-3 fatty acids in major depressive disorder (A preliminary double-blind, placebo-controlled trial). Eur Neuropsychopharmacol. 2003;13:267–271
  18. Suzuki S, Akechi T, Kobayashi M, Taniguchi K, Goto K, Sasaki S, et al. Daily omega-3 fatty acid intake and depression in Japanese patients with newly diagnosed lung cancer. Br J Cancer. 2004;90:787–793
  19. Marangell LB, Martinez JM, Zboyan HA, Kertz B, Kim HFS, Puryear LJ. A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. Am J Psychiatry. 2003;160:996–998
  20. Hakkarainen R, Partonen T, Haukka J, Virtamo J, Albanes D, Lönnqvist J. Is low dietary intake of omega-3 fatty acids associated with depression?. Am J Psychiatry. 2004;161:567–569
  21. Silvers KM, Woolley CC, Hamilton FC, Watts PM, Watson RA. Randomised double-blind placebo-controlled trial of fish oil in the treatment of depression. Prostaglandins Leukot Essent Fatty Acids. 2005;72:211–218
  22. Appleton KM, Hayward RC, Gunnell D, Peters TJ, Rogers PJ, Kessler D, et al. Effects of n-3 long-chain polyunsaturated fatty acids on depressed mood: systematic review of published trials. Am J Clin Nutr. 2006;84:1308–1316
  23. Freeman MP, Hibbeln JR, Wisner KL, Davis JM, Mischoulon D, Peet M, et al. Omega-3 fatty acids: Evidence basis for treatment and future research in psychiatry. J Clin Psychiatry. 2006;67:1954–1967
  24. Parker G, Gibson NA, Brotchie H, Heruc G, Rees A-M, Hadzi-Pavlovic D. Omega-3 fatty acids and mood disorders. Am J Psychiatry. 2006;163:969–978
  25. Marangell LB, Martinez JM, Zboyan HA, Chong H, Puryear LJ. Omega-3 fatty acids for the prevention of postpartum depression: negative data form a preliminary, open-label pilot study. Depress Anxiety. 2004;19:20–23
  26. Eritsland J, Arnesen H, Gronseth K, Fjeld NB, Abdelnoor M. Effect of dietary supplementation with n-3 fatty acids on coronary artery bypass graft patency. Am J Cardiol. 1996;77:31–36
  27. Von Schacky C, Angerer P, Kothny W, Theisen K, Mudra H. The effect of dietary omega-3 fatty acids on coronary atherosclerosis: a randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1999;130:554–562
  28. Wheaton DH, Hoffman DR, Locke KG, Watkins RB, Birch DG. Biological safety assessment of docosahexaenoic acid supplementation in a randomized clinical trial for X-linked retinitis pigmentosa. Arch Ophthalmol. 2003;121:1269–1278
  29. Wohl DA, Tien HC, Busby M, Cunningham C, Macintosh B, Napravnik S, et al. Randomized study of the safety and efficacy of fish oil (omega-3 fatty acid) supplementation with dietary and exercise counseling for the treatment of antiretroviral therapy-associated hypertriglyceridemia. Clin Infect Dis. 2005;41:1498–1504
  30. McDonald A, Van Horn L, Slattery M, Hilner J, Bragg C, Caan B, et al. The CARDIA dietary history: development, implementation, and evaluation. J Am Diet Assoc. 1991;91:1104–1112
  31. Friedman GD, Cutter GR, Donahue RP, Hughes GH, Hulley SB, Jacobs DR, et al. CARDIA: study design, recruitment, and some characteristics of the examined subjects. J Clin Epidemiol. 1988;41:1105–1116
  32. Goldberg GR, Black AE, Jebb SA, Cole TJ, Murgatroyd PR, Coward WA, et al. Critical evaluation of energy intake data using fundamental principles of energy physiology: 1. Derivation of cut-off limits to identify under-reporting. Eur J Clin Nutr. 1991;45:569–581
  33. Stoll AL, Severus WE, Freeman MP, Rueter S, Zboyan HA, Diamond E, et al. Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial. Arch Gen Psychiatry. 1999;56:407–412
  34. Hilner JE, McDonald A, Van Horn L, Bragg C, Caan B, Slattery ML, et al. Quality control of dietary data collection in the CARDIA study. Control Clin Trials. 1992;13:156–169
  35. Liu K, Slattery M, Jacobs D, Cutter G, McDonald A, Van Horn L, et al. A study of the reliability and comparative validity of the CARDIA dietary history. Ethn Dis. 1994;4:15–27
  36. Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Measurement. 1977;1:385–401
  37. Radloff LS, Locke BZ. The Community Mental Health Assessment Survey and the CES-D Scale. In:  Weissman MM,  Myers JK,  Ross CE editor. Community surveys of psychiatric disorders. Volume 4. New Brunswick, NJ: Rutgers University Press; 1986;p. 177–187
  38. Tobin MD, Sheehan NA, Scurrah KJ, Burton PR. Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure. Stat Med. 2005;24:2911–2935
  39. Dunn JE, Liu K, Greenland P, Hilner JE, Jacobs DR. Seven-year tracking of dietary factors in young adults: the CARDIA study. Am J Prev Med. 2000;18:38–45
  40. Dyer AR, Cutter GR, Liu K, Armstrong MA, Friedman GD, Hughes GH, et al. Alcohol intake and blood pressure in young adults: the CARDIA study. J Clin Epidemiol. 1990;43:1–13
  41. Jacobs DR, Hahn LP, Haskell WL, Pirie P, Sidney S. Validity and reliability of short physical activity history: CARDIA and the Minnesota Heart Health program. J Cardiopulm Rehabil. 1989;9:448–459
  42. Willett W, Stampfer MJ. Total energy intake: implications for epidemiologic analyses. Am J Epidemiol. 1986;124:17–27
  43. Goyens PLL, Spilker ME, Zock PL, Katan MB, Mensink RP. Conversion of α-linolenic acid in humans is influenced by the absolute amounts of α-linolenic acid and linoleic acid in the diet and not by their ratio. Am J Clin Nutr. 2006;84:44–53
  44. Sanchez-Villegas A, Henriquez P, Figueiras A, Ortuño F, Lahortiga F, Martinez-Gonzalez MA. Long chain omega-3 fatty acids intake, fish consumption and mental disorders in the SUN cohort study. Eur J Nutr. 2007;46:337–346
  45. Murakami K, Mizoue T, Sasaki S, Ohta M, Sato M, Matsushita Y, et al. Dietary intake of folate, other B vitamins, and ω-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults. Nutrition. 2008;24:140–147
  46. Giltay EJ, Gooren LJG, Toorians AWFT, Katan MB, Zock PL. Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. Am J Clin Nutr. 2004;80:1167–1174
  47. Delion S, Chalon S, Hérault J, Guilloteau D, Besnard J-C, Durand G. Chronic dietary α-linolenic acid deficiency alters dopaminergic and serotoninergic neurotransmission in rats. J Nutr. 1994;124:2466–2476
  48. Delion S, Chalon S, Guilloteau D, Besnard JC, Durand G. α-Linolenic acid dietary deficiency alters age-related changes of dopaminergic and serotoninergic neurotransmission in the rat frontal cortex. J Neurochem. 1996;66:1582–1591
  49. Meyer JH, McMain S, Kennedy SH, Korman L, Brown GM, DaSilva JN, et al. Dysfunctional attitudes and 5-HT2 receptors during depression and self-harm. Am J Psychiatry. 2003;160:90–99
  50. Strome EM, Clark CM, Zis AP, Doudet DJ. Electroconvulsive shock decreases binding to 5-HT2 receptors in nonhuman primates: an in vivo positron emission tomography study with [18F]setoperone. Biol Psychiatry. 2005;57:1004–1010
  51. Yatham LN, Liddle PF, Shiah I-S, Scarrow G, Lam RW, Adam MJ, et al. Brain serotonin2 receptors in major depression. Arch Gen Psychiatry. 2000;57:850–858
  52. Chalon S, Delion-Vancassel S, Belzung C, Guilloteau D, Leguisquet A-M, Besnard J-C, et al. Dietary fish oil affects monoaminergic neurotransmission and behavior in rats. J Nutr. 1998;128:2512–2519
  53. Carlezon WA, Mague SD, Parow AM, Stoll AL, Cohen BM, Renshaw PF. Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats. Biol Psychiatry. 2005;57:343–350
  54. Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 2008;9:46–56
  55. Schmitz G, Ecker J. The opposing effects of n-3 and n-6 fatty acids. Prog Lipid Res. 2008;47:147–155
  56. Appleton KM, Woodside JV, Yarnell JWG, Arveiler D, Haas B, Amouyel P, et al. Depressed mood and dietary fish intake: direct relationship or indirect relationship as a result of diet and lifestyle?. J Affect Disord. 2007;104:217–223
  57. Appleton KM, Peters TJ, Hayward RC, Heatherley SV, McNaughton SA, Rogers PJ, et al. Depressed mood and n-3 polyunsaturated fatty acid intake from fish: non-linear or confounded association?. Soc Psychiatry Psychiatr Epidemiol. 2007;42:100–104
  58. McDowell I. Measuring health: a guide to rating scales and questionnaires. New York: Oxford University Press; 1996;p. 353

 This research was funded by contracts N01-HC-48047 through 48050 and N01-HC-95095 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.

PII: S0899-9007(09)00007-0

doi: 10.1016/j.nut.2008.12.008

Nutrition
Volume 25, Issue 10 , Pages 1011-1019 , October 2009

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