Nutrition
Volume 25, Issue 5 , Pages 567-573 , May 2009

Plum juice, but not dried plum powder, is effective in mitigating cognitive deficits in aged rats

  • Barbara Shukitt-Hale, Ph.D.

      Affiliations

    • USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    • Corresponding Author InformationCorresponding author. Tel.: +617-556-3118; fax: +617-556-3222
    • ,
  • Wilhelmina Kalt, Ph.D.

      Affiliations

    • Agriculture and Agri-Food Canada, Kentville Research Centre, Kentville, Nova Scotia, Canada
    • ,
  • Amanda N. Carey, M.A.

      Affiliations

    • USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    • ,
  • Melinda Vinqvist-Tymchuk, M.S.

      Affiliations

    • Agriculture and Agri-Food Canada, Kentville Research Centre, Kentville, Nova Scotia, Canada
    • ,
  • Jane McDonald, B.S.

      Affiliations

    • Agriculture and Agri-Food Canada, Kentville Research Centre, Kentville, Nova Scotia, Canada
    • ,
  • James A. Joseph, Ph.D.

      Affiliations

    • USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA

Received 28 July 2008 ,Accepted 26 October 2008.

References 

  1. Brandeis R, Brandys Y, Yehuda S. The use of the Morris water maze in the study of memory and learning. Int J Neurosci. 1989;48:29–69
  2. Ingram DK, Jucker M, Spangler E. Behavioral manifestations of aging. In:  Capen CC editors. Pathobiology of the aging rat. Washington, DC: ILSI; 1994;p. 149–170
  3. Keller JN. Age-related neuropathology, cognitive decline, and Alzheimer's disease. Ageing Res Rev. 2006;5:1–13
  4. Shukitt-Hale B, Mouzakis G, Joseph JA. Psychomotor and spatial memory performance in aging male Fischer 344 rats. Exp Gerontol. 1998;33:615–624
  5. Joseph JA, Shukitt-Hale B, Casadesus G. Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds. Am J Clin Nutr. 2005;81(suppl):313S–316
  6. Shukitt-Hale B. The effects of aging and oxidative stress on psychomotor and cognitive behavior. Age. 1999;22:9–17
  7. Esposito E, Rotilio D, Di Matteo V, Di Giulio C, Cacchio M, Algeri S. A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes. Neurobiol Aging. 2002;23:719–735
  8. Evans DA, Funkenstein HH, Albert MS, Scherr PA, Cook NR, Chown MJ, et al. Prevalence of Alzheimer's disease in a community population of older persons (Higher than previously reported). JAMA. 1989;262:2551–2556
  9. Nicita-Mauro V. Parkinson's disease, Parkinsonism and aging. Arch Gerontol Geriatr. 2002;8(suppl):225–238
  10. Cao G, Sofic E, Prior RL. Antioxidant capacity of tea and common vegetables. J Agric Food Chem. 1996;44:3426–3431
  11. Wang H, Cao G, Prior RL. Total antioxidant capacity of fruits. J Agric Food Chem. 1996;44:701–705
  12. Shukitt-Hale B, Galli R, Meterko V, Carey A, Bielinski D, McGhie T, et al. Dietary supplementation with fruit polyphenolics ameliorates age-related deficits in behavior and neuronal markers of inflammation and oxidative stress. Age. 2005;27:49–57
  13. Stevenson DE, Hurst RD. Polyphenolic phytochemicals—just antioxidants or much more?. Cell Mol Life Sci. 2007;64:2900–2916
  14. Shukitt-Hale B, Carey A, Simon L, Mark DA, Joseph JA. The effects of Concord grape juice on cognitive and motor deficits in aging. Nutrition. 2006;22:295–302
  15. Joseph JA, Shukitt-Hale B, Denisova NA, Bielinski D, Martin A, McEwen JJ, et al. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci. 1999;19:8114–8121
  16. Youdim KA, Shukitt-Hale B, Martin A, Wang H, Denisova N, Bickford PC, et al. Short-term dietary supplementation of blueberry polyphenolics: beneficial effects on aging brain performance and peripheral tissue function. Nutr Neurosci. 2000;3:383–397
  17. Bickford PC, Shukitt-Hale B, Joseph J. Effects of aging on cerebellar noradrenergic function and motor learning: nutritional interventions. Mech Ageing Dev. 1999;111:141–154
  18. Bickford PC, Gould T, Briederick L, Chadman K, Pollock A, Young D, et al. Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats. Brain Res. 2000;866:211–217
  19. Goyarzu P, Malin DH, Lau FC, Taglialatela G, Moon WD, Jennings R, et al. Blueberry supplemented diet: effects on object recognition memory and nuclear factor-kappa B levels in aged rats. Nutr Neurosci. 2004;7:75–83
  20. Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE, Prior RL. Lipophilic and hydrophilic antioxidant capacities of common foods in the United States. J Agric Food Chem. 2004;52:4026–4037
  21. Donovan JL, Meyer AS, Waterhouse AL. Phenolic composition and antioxidant activity of prunes and prune juice (Prunus domestica). J Agric Food Chem. 1998;46:1247–1252
  22. Stacewicz-Sapuntzakis M, Bowen PE, Hussain EA, Damayanti-Wood BI, Farnsworth NR. Chemical composition and potential health effects of prunes: a functional food?. Crit Rev Food Sci Nutr. 2001;41:251–286
  23. Del Caro A, Piga A, Pinna I, Fenu PM, Agabbio M. Effect of drying conditions and storage period on polyphenolic content, antioxidant capacity, and ascorbic acid of prunes. J Agric Food Chem. 2004;52:4780–4784
  24. Fang N, Yu S, Prior RL. LC/MS/MS characterization of phenolic constituents in dried plums. J Agric Food Chem. 2002;50:3579–3585
  25. Kayano S, Yamada NF, Suzuki T, Ikami T, Shioaki K, Kikuzaki H, et al. Quantitative evaluation of antioxidant components in prunes (Prunus domestica L.). J Agric Food Chem. 2003;51:1480–1485
  26. Casadesus G, Shukitt-Hale B, Stellwagen HM, Zhu X, Lee HG, Smith MA, et al. Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutr Neurosci. 2004;7:309–316
  27. Joseph JA, Arendash G, Gordon M, Diamond D, Shukitt-Hale B, Morgan D. Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci. 2003;6:153–162
  28. Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic. 1965;16:144–158
  29. Ou B, Hampsch-Woodill M, Prior RL. Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe. J Agric Food Chem. 2001;49:4619–4626
  30. Morris R. Development of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods. 1984;11:47–60
  31. Ingram DK, Jucker M, Spangler EL. Behavioral manifestations of aging. In:  Mohr U,  Cungworth DL,  Capen CC editor. Pathobiology of the aging rat. Washington: ILSI; 1994;p. 149–170
  32. Proteggente AR, Saija A, De Pasquale A, Rice-Evans CA. The compositional characterisation and antioxidant activity of fresh juices from Sicilian sweet orange (Citrus sinensis L. Osbeck) varieties. Free Radic Res. 2003;37:681–687
  33. Youdim KA, McDonald J, Kalt W, Joseph JA. Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults (small star, filled). J Nutr Biochem. 2002;13:282–288
  34. Auger C, Laurent N, Laurent C, Besancon P, Caporiccio B, Teissedre PL, et al. Hydroxycinnamic acids do not prevent aortic atherosclerosis in hypercholesterolemic golden Syrian hamsters. Life Sci. 2004;74:2365–2377
  35. Yang Y, Gallaher DD. Effect of dried plums on colon cancer risk factors in rats. Nutr Cancer. 2005;53:117–125
  36. Kalt W, Joseph JA, Shukitt-Hale B. Blueberries and human health: a review of current research. J Am Pomol Soc. 2007;61:151–160
  37. Macheix J-J, Fleuriet A, Billot J. Fruit phenolics. Boca Raton: CRC Press; 1990;

 Financial support was provided, in part, by the California Dried Plum Board (Sacramento, CA).

PII: S0899-9007(08)00449-8

doi: 10.1016/j.nut.2008.10.018

Nutrition
Volume 25, Issue 5 , Pages 567-573 , May 2009

Article Tools

* Image Usage & Resolution