Nutrition
Volume 25, Issue 5 , Pages 555-566 , May 2009

Inhibition of proliferation and induction of apoptosis by γ-tocotrienol in human colon carcinoma HT-29 cells

  • Wei-Li Xu, Ph.D.

      Affiliations

    • Department of Nutrition and Food Hygiene, Public Health School, Harbin Medical University, Harbin, People's Republic of China
    • School of Food Science and Engineering, Harbin Institute of Technology, Harbin, Heilongjiang, People's Republic of China
    • ,
  • Jia-Ren Liu, Ph.D.

      Affiliations

    • Department of Nutrition and Food Hygiene, Public Health School, Harbin Medical University, Harbin, People's Republic of China
    • Agricultural Research Station, Virginia State University, Petersburg, Virginia, USA
    • ,
  • Hui-Kun Liu, Ph.D.

      Affiliations

    • Department of Nutrition and Food Hygiene, Public Health School, Harbin Medical University, Harbin, People's Republic of China
    • ,
  • Gui-Yun Qi, Ph.D.

      Affiliations

    • Department of Nutrition and Food Hygiene, Public Health School, Harbin Medical University, Harbin, People's Republic of China
    • ,
  • Xiang-Rong Sun, Ph.D.

      Affiliations

    • Department of Nutrition and Food Hygiene, Public Health School, Harbin Medical University, Harbin, People's Republic of China
    • ,
  • Wen-Guang Sun, Ph.D.

      Affiliations

    • Department of Nutrition and Food Hygiene, Public Health School, Harbin Medical University, Harbin, People's Republic of China
    • ,
  • Bing-Qing Chen

      Affiliations

    • Department of Nutrition and Food Hygiene, Public Health School, Harbin Medical University, Harbin, People's Republic of China
    • Corresponding Author InformationCorresponding author. Tel.: +86-451-8750-2961; fax: +86-451-8750-2885

Received 13 June 2008 ,Accepted 17 October 2008.

References 

  1. Packer L, Weber SU, Rimbach G. Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling. J Nutr. 2001;131:369S–373
  2. McLaughlin PJ, Weihrauch JL. Vitamin E content of foods. J Am Diet Assoc. 1979;75:647–665
  3. Cottrell RC. Introduction: nutritional aspects of palm oil. Am J Clin Nutr. 1991;53(suppl):989S–1009
  4. Elson CE. Tropical oils: nutritional and scientific issues. Crit Rev Food Sci Nutr. 1992;31:79–102
  5. Sylvester PW, Russell M, Ip MM, Ip C. Comparative effects of different animal and vegetable fats fed before and during carcinogen administration on mammary tumorigenesis, sexual maturation, and endocrine function in rats. Cancer Res. 1986;46:757–762
  6. Nesaretnam K, Khor HT, Ganeson J, Chong YH, Sun-dram K, Gapor A. The effect of vitamin E tocotrienols from palm oil on chemically induced mammary carcinogenesis in female rats. Nutr Res. 1992;12:879–892
  7. He L, Mo H, Hadisusilo S, Qureshi AA, Elson CE. Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. J Nutr. 1997;127:668–674
  8. Agarwal MK, Agarwal ML, Athar M, Gupta S. Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle association. Cell Cycle. 2004;3:205–211
  9. Srivastava JK, Gupta S. Tocotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cells. Biochem Biophys Res Commun. 2006;346:447–453
  10. Sylvester PW, Nachnani A, Shah S, Briski KP. Role of GTP-binding proteins in reversing the antiproliferative effects of tocotrienols in preneoplastic mammary epithelial cells. Asia Pac J Clin Nutr. 2002;11(suppl 7):S452–S459
  11. McIntyre BS, Briski KP, Gapor A, Sylvester PW. Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mouse mammary epithelial cells. Pro Soc Exp Biol Med. 2000;224:292–301
  12. McIntyre BS, Briski KP, Tirmenstein MA, Fariss MW, Gapor A, Sylvester PW. Antiproliferative and apoptotic effects of tocopherols and tocotrienols on normal mouse mammary epithelial cells. Lipids. 2000;35:171–180
  13. Sylvester PW, Shah SJ. Mechanisms mediating the antiproliferative and apoptotic effects of vitamin E in mammary cancer cells. Front Biosci. 2005;10:699–709
  14. Liu HK, Wang Q, Li W, Sun WG, Liu JR, Yang YM, et al. Inhibitory effects of γ-tocotrienol on invasion and metastasis of human gastric adenocarcinoma SGC-7901 cells. J Nutr Biochem. 2008;(in press)
  15. Yu W, Simmons-Menchaca M, Gapor A, Sanders BG, Kline K. Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. Nutr Cancer. 1999;33:26–32
  16. Sylvester PW, McIntyre BS, Gapor A, Briski KP. Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation. Cell Prolif. 2001;34:347–357
  17. Takahashi K, Loo G. Disruption of mitochondria during tocotrienol-induced apoptosis in MDA-MB-231 human breast cancer cells. Biochem Pharmacol. 2004;67:315–324
  18. Wada S, Satomi Y, Murakoshi M, Noguchi N, Yoshikawa T, Nishino H. Tumor suppressive effects of tocotrienol in vivo and in vitro. Cancer Lett. 2005;229:181–191
  19. Sakai M, Okabe M, Tachibana H, Yamada K. Apoptosis induction by gamma-tocotrienol in human hepatoma Hep3B cells. J Nutr Biochem. 2006;17:672–676
  20. Sun W, Wang Q, Chen B, Liu J, Liu H, Xu W. Gamma-tocotrienol–induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling. Br J Nutr. 2008;99:1247–1254
  21. Conte C, Floridi A, Aisa C, Piroddi M, Galli F. Gamma-tocotrienol metabolism and antiproliferative effect in prostate cancer cells. Ann N Y Acad Sci. 2004;1031:391–394
  22. Shah SJ, Sylvester PW. Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity. Exp Biol Med. 2005;230:235–241
  23. Labianca R, Beretta G, Gatta G, de Braud F, Wils J. Colon cancer. Crit Rev Oncol Hematol. 2004;51:145–170
  24. Gustin DM, Brenner DE. Chemoprevention of colon cancer: current status and future prospects. Cancer Metastasis Rev. 2002;21:323–348
  25. Stone WL, Papas AM. Tocopherols and the etiology of colon cancer. J Natl Cancer Inst. 1997;89:1006–1014
  26. Li CJ, Li YZ, Pinto AV, Pardee AB. Potent inhibition of tumor survival in vivo by beta-lapachone plus taxol: combining drugs imposes different artificial checkpoints. Proc Natl Acad Sci U S A. 1999;96:13369–13374
  27. Sylte MJ, Corbeil LB, Inzana TJ, Czuprynski CJ. Haemophilus somnus induces apoptosis in bovine endothelial cells in vitro. Infect Immun. 2001;69:1650–1660
  28. Lee YJ, Yin HQ, Kim YH, Li GY, Lee BH. Apoptosis inducing effects of 6-methoxydihydrosanguinarine in HT29 colon carcinoma cells. Arch Pharm Res. 2004;27:1253–1257
  29. Kiefer MC, Brauer MJ, Powers VC, Wu JJ, Umansky SR, Tomei LD, et al. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature. 1995;374(6524):736–739
  30. Yang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell. 1995;80:285–291
  31. Schlosser SF, Schuler M, Berg CP, Lauber K, Schulze-Osthoff K, Schmahl FW, et al. Ribavirin and alpha interferon enhance death receptor-mediated apoptosis and caspase activation in human hepatoma cells. Antimicrob Agents Chemother. 2003;47:1912–1921
  32. Kim WH, Yeo M, Kim MS, Chun SB, Shin EC, Park JH, et al. Role of caspase-3 in apoptosis of colon cancer cells induced by nonsteroidal anti-inflammatory drugs. Int J Colorectal Dis. 2000;15:105–111
  33. Lind DS, Hochwald SN, Malaty J, Rekkas S, Hebig P, Mishra G, et al. Nuclear factor-kappa B is upregulated in colorectal cancer. Surgery. 2001;130:363–369
  34. Inan MS, Rasoulpour RJ, Yin L, Hubbard AK, Rosenberg DW, Giardina C. The luminal short-chain fatty acid butyrate modulates NF-kappaB activity in a human colonic epithelial cell line. Gastroenterology. 2000;118:724–734
  35. Liu JR, Sun XR, Dong HW, Sun CH, Sun WG, Chen BQ, et al. Beta-ionone suppresses mammary carcinogenesis, proliferative activity and induces apoptosis in the mammary gland of the Sprague-Dawley rat. Int J Cancer. 2008;122:2689–2698
  36. American Institute for Cancer Research. Plant compounds continue to challenge science. www.aicr.org/site/PageServer
  37. Shah S, Gapor A, Sylvester PW. Role of caspase-8 activation in mediating vitamin E–induced apoptosis in murine mammary cancer cells. Nutr Cancer. 2003;45:236–246
  38. Sylvester PW, Shah SJ, Samant GV. Intracellular signaling mechanisms mediating the antiproliferative and apoptotic effects of gamma-tocotrienol in neoplastic mammary epithelial cells. J Plant Physiol. 2005;162:803–810
  39. Mo H, Elson CE. Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids. J Nutr. 1999;129:804–813
  40. Liu JR, Chen BQ, Yang BF, Dong HW, Sun CH, Wang Q, et al. Apoptosis of human gastric adenocarcinoma cells induced by beta-ionone. World J Gastroenterol. 2004;10:348–351
  41. Hannun YA. Apoptosis and the dilemma of cancer chemotherapy. Blood. 1997;89:1845–1853
  42. Simstein R, Burow M, Parker A, Weldon C, Beckman B. Apoptosis, chemoresistance, and breast cancer: insights from the MCF-7 cell model system. Exp Biol Med. 2003;228:995–1003
  43. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science. 1998;281(5381):1322–1326
  44. Fan XQ, Guo YJ. Apoptosis in oncology. Cell Res. 2001;11:1–7
  45. Korsmeyer SJ. BCL-2 gene family and the regulation of programmed cell death. Cancer Res. 1999;59(sSuppl):1693s–1700
  46. Cohen GM. Caspases: the executioners of apoptosis. Biochem J. 1997;326(pt 1):1–16
  47. Nagata S. Apoptosis by death factor. Cell. 1997;88:355–365
  48. Communal C, Sumandea M, de Tombe P, Narula J, Solaro RJ, Hajjar RJ. Functional consequences of caspase activation in cardiac myocytes. Proc Natl Acad Sci U S A. 2002;99:6252–6256
  49. Sakai M, Okabe M, Yamasaki M, Tachibana H, Yamada K. Induction of apoptosis by tocotrienol in rat hepatoma dRLh-84 cells. Anticancer Res. 2004;24(suppl 3a):1683–1688
  50. Gilmore TD. The Re1/NF-kappa B/I kappa B signal transduction pathway and cancer. Cancer Treat Res. 2003;115:241–265
  51. Vermeulen L, De Wilde G, Notebaert S, Vanden Berghe W, Haegeman G. Regulation of the transcriptional activity of the nuclear factor-kappaB p65 subunit. Biochem Pharmacol. 2002;64:963–970
  52. Pahl HL. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene. 1999;18:6853–6866
  53. Joyce D, Albanese C, Steer J, Fu M, Bouzahzah B, Pestell RG. NF-kappaB and cell-cycle regulation: the cyclin connection. Cytokine Growth Factor Rev. 2001;12:73–90
  54. Yu LL, Yu HG, Yu JP, Luo HS, Xu XM, Li JH. Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human colorectal carcinoma tissue. World J Gastroenterol. 2004;10:3255–3260
  55. Campbell KJ, Rocha S, Perkins ND. Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B. Mol Cell. 2004;13:853–865
  56. Barkett M, Gilmore TD. Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene. 1999;18:6910–6924

 This project was supported by the National Natural Science Foundation of China (grant 30471444).

PII: S0899-9007(08)00448-6

doi: 10.1016/j.nut.2008.10.019

Nutrition
Volume 25, Issue 5 , Pages 555-566 , May 2009

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