Nutrition
Volume 24, Issue 10 , Pages 933-940, October 2008

Effect of milk tripeptides on blood pressure: A meta-analysis of randomized controlled trials

  • Jia-Ying Xu, M.S.M.

      Affiliations

    • School of Radiation Medicine and Public Health, Soochow University, Suzhou, China
    • ,
  • Li-Qiang Qin, Ph.D.

      Affiliations

    • School of Radiation Medicine and Public Health, Soochow University, Suzhou, China
    • ,
  • Pei-Yu Wang, Ph.D.

      Affiliations

    • Department of Social Medicine and Health Education, School of Public Health, Peking University, Beijing, China
    • ,
  • Wei Li, B.S. Med

      Affiliations

    • School of Radiation Medicine and Public Health, Soochow University, Suzhou, China
    • ,
  • Chun Chang, Ph.D.

      Affiliations

    • Department of Social Medicine and Health Education, School of Public Health, Peking University, Beijing, China
    • Corresponding Author InformationCorresponding author. Tel.: +86-10-8280-2502; fax: +86-10-8280-2002

Received 29 November 2007; accepted 18 April 2008. published online 19 June 2008.

Abstract 

Objective

To better understand and summarize the relation between milk peptide intake and blood pressure (BP), we conducted a meta-analysis of randomized controlled trials to assess the effects of the milk-derived tripeptides isoleucine-proline-proline and valine-proline-proline on BP in prehypertensive and hypertensive subjects.

Methods

Nine studies including 12 trials published between 1996 and 2005 with a total of 623 participants were included. Two researchers independently extracted data from the original publications. A fixed-effects model was used for meta-analysis because of the homogeneity among trials.

Results

Significant decreases of 4.8 mmHg (95% confidence interval 3.7–6.0) in systolic BP and 2.2 mmHg (95% confidence interval 1.3–3.1) in diastolic BP were found after the pooling of these trials. When trials were separated by BP status, hypotensive effects appeared to be larger in hypertensive subjects than in prehypertensive subjects. As a trend, the hypotensive effects became more obvious as the intervention lengthened.

Conclusion

Our analysis provided evidence that milk-derived tripeptides have hypotensive effects in prehypertensive and hypertensive subjects.

Keywords: Milk, Tripeptide, Blood pressure, Hypertension, Meta-analysis

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 This work was supported by the National Natural Science Foundation of China (grant 30771808) and the Medical Developmental Foundation of Soochow University (grant EE126712).

PII: S0899-9007(08)00202-5

doi:10.1016/j.nut.2008.04.004

Nutrition
Volume 24, Issue 10 , Pages 933-940, October 2008

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