Influence of Ala54Thr polymorphism of fatty acid–binding protein-2 on clinical results of biliopancreatic diversion

de Luis, Daniel A.; Sagrado, Manuel González; Izaola, Olatz; Terroba, Maria Concepcion; Cuellar, Luis; Conde, Rosa; Martin, Tomas

doi:10.1016/j.nut.2007.12.009

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Volume 24, Issue 4 , Pages 300-304, April 2008

Influence of Ala54Thr polymorphism of fatty acid–binding protein-2 on clinical results of biliopancreatic diversion

Daniel A. de Luis, M.D.
- Institute of Endocrinology and Nutrition, Medical School, University of Valladolid, Valladolid, Spain
- Unit of Investigation, Surgical and Endocrinology Departments, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
- Corresponding author. Tel.: +3498-342-0400; fax: +3498-315-3366.
Manuel González Sagrado, M.D.
- Institute of Endocrinology and Nutrition, Medical School, University of Valladolid, Valladolid, Spain
- Unit of Investigation, Surgical and Endocrinology Departments, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Olatz Izaola, Ph.D.
- Institute of Endocrinology and Nutrition, Medical School, University of Valladolid, Valladolid, Spain
- Unit of Investigation, Surgical and Endocrinology Departments, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Maria Concepcion Terroba, Ph.D.
- Institute of Endocrinology and Nutrition, Medical School, University of Valladolid, Valladolid, Spain
Luis Cuellar, M.D.
- Institute of Endocrinology and Nutrition, Medical School, University of Valladolid, Valladolid, Spain
Rosa Conde, M.D.
- Institute of Endocrinology and Nutrition, Medical School, University of Valladolid, Valladolid, Spain
- Unit of Investigation, Surgical and Endocrinology Departments, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Tomas Martin, Ph.D.
- Institute of Endocrinology and Nutrition, Medical School, University of Valladolid, Valladolid, Spain

Received 25 May 2007; accepted 13 December 2007. published online 18 February 2008.

Abstract

Objective

Bariatric surgery is the most effective long-term treatment for morbid obesity, reducing obesity-associated comorbidities. The purpose of the present study was to evaluate the fatty acid–binding protein-2 Ala54Thr polymorphism outcomes 1 y after biliopancreatic diversion in morbidly obese patients.

Methods

A sample of 41 morbidly obese patients (body mass index >40 kg/m²) were operated upon from December 2004 to December 2006. Weight, fat mass, blood pressure, basal glucose, triacylglycerides, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were measured at the basal visit and at each visit. The frequency of patients with diabetes mellitus, hypertension, and hyperlipidemia was recorded at each visit.

Results

Twenty-three patients (56.1%) had genotype Ala54/Ala54 (wild group) and 18 patients had genotype Ala54/Thr54 (15 patients, 36.5%) or Thr54/Thr54 (3 patients, 7.4%; mutant group). In the wild group, body mass index, weight, fat mass, systolic blood pressure, glucose, total cholesterol, low-density lipoprotein cholesterol, and triacylglycerol concentrations decreased. Diastolic blood pressure remained unchanged. In the mutant group, the same parameters improved, without statistical differences from the wild group. Initial excess weight percent loss at 1 y of follow-up was similar in both genotype groups (61.8% versus 61.9%, NS).