Nutrition
Volume 23, Issue 7 , Pages 617-621 , July 2007

Orange pulp improves antioxidant status and suppresses lipid peroxidation in orchidectomized male rats

  • Farzad Deyhim, Ph.D., R.D., L.D.

      Affiliations

    • Human Sciences, Texas A&M University–Kingsville, Kingsville, Texas, USA
    • Vegetable and Fruit Improvement Center, Department of Horticultural Sciences, Texas A&M University, College Station, Texas, USA
    • Corresponding Author InformationCorresponding author. Tel.: +361-593-2409; fax: +361-593-2230.
  • ,
  • Arnulfo Villarreal, B.S.

      Affiliations

    • Human Sciences, Texas A&M University–Kingsville, Kingsville, Texas, USA
  • ,
  • Kristi Garcia, B.S.

      Affiliations

    • Human Sciences, Texas A&M University–Kingsville, Kingsville, Texas, USA
  • ,
  • Ryan Rios, B.S.

      Affiliations

    • Human Sciences, Texas A&M University–Kingsville, Kingsville, Texas, USA
  • ,
  • Claudia Garcia, B.S.

      Affiliations

    • Human Sciences, Texas A&M University–Kingsville, Kingsville, Texas, USA
  • ,
  • Cheri Gonzales, B.S.

      Affiliations

    • Human Sciences, Texas A&M University–Kingsville, Kingsville, Texas, USA
  • ,
  • Kranthi Mandadi, B.S., M.S.

      Affiliations

    • Vegetable and Fruit Improvement Center, Department of Horticultural Sciences, Texas A&M University, College Station, Texas, USA
    • Texas A&M University–Kingsville, Citrus Center, Weslaco, Texas, USA
  • ,
  • Bhimanagouda S. Patil, Ph.D.

      Affiliations

    • Human Sciences, Texas A&M University–Kingsville, Kingsville, Texas, USA
    • Vegetable and Fruit Improvement Center, Department of Horticultural Sciences, Texas A&M University, College Station, Texas, USA

Received 13 December 2006 ,Accepted 24 April 2007.

References 

  1. Dunajska K, Milewicz A, Szymczak J, Jedrzejuk D, Kuliczkowski W, Salomon P, et al. Evaluation of sex hormone levels and some metabolic factors in men with coronary atherosclerosis. Aging Male. 2004;7:197–204
  2. Deyhim F, Lopez E, Gonzalez J, Garcia M, Patil BS. Citrus juice modulates antioxidant enzymes and lipid profiles in orchidectomized rats. J Med Food. 2006;9:422–426
  3. Sreelatha Kumari KT, Menon VP, Leelamma S. Testosterone and lipid peroxide metabolism in orchidectomised rats. Indian J Exp Biol. 1993;31:323–326
  4. Smith SC, Jackson R, Pearson TA, Fuster V, Yusuf S, Faergeman O, et al. Principles for national and regional guidelines on cardiovascular disease prevention: a scientific statement from the World Heart and Stroke Forum. Circulation. 2004;109:3112–3121
  5. Montilla P, Espejo I, Munoz MC, Bujalance I, Munoz-Castaneda JR, Tunez I. Protective effect of red wine on oxidative stress and antioxidant enzyme activities in the brain and kidney induced by feeding high cholesterol in rats. Clin Nutr. 2006;25:146–153
  6. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000;342:836–843
  7. Ridker PM. High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. Circulation. 2001;103:1813–1818
  8. Verma S, Kuliszewski MA, Li SH, Szmitko PE, Zucco L, Wang CH, et al. C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function. Circulation. 2004;109:2058–2067
  9. Libby P. Inflammation in atherosclerosis. Nature. 2002;420:868–874
  10. Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res. 2000;87:840–844
  11. Harrison D, Griendling KK, Landmesser U, Hornig B, Drexler H. Role of oxidative stress in atherosclerosis. Am J Cardiol. 2003;91(suppl):7A11
  12. Rajasekhar D, Srinivasa Rao PVLN, Latheef SAA, Saibaba KSS, Subramanyam G. Association of serum antioxidants and risk of coronary heart disease in South Indian population. Indian J Med Sci. 2004;58:465–471
  13. Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet. 1993;342:1007–1011
  14. Schroeter H, Heiss C, Balzer J, Kleinbongard P, Keen CL, Hollenberg NK, et al. (−)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci U S A. 2006;103:1024–1029
  15. Lagiou P, Samoli E, Lagiou A, Skalkidis Y, Katsouyanni K, Petridou E, et al. Flavonoid classes and risk of peripheral arterial occlusive disease: a case-control study in Greece. Eur J Clin Nut. 2006;60:214–219
  16. Lapointe A, Couillard C, Lemieux S. Effects of dietary factors on oxidation of low-density lipoprotein particles. J Nutr Biochem. 2006;17:645–658
  17. Vita JA. Polyphenols and cardiovascular disease: effects on endothelial and platelet function. Am J Clin Nutr. 2005;81:292S7
  18. National Research Council. Guide for the care and use of laboratory animals. Washington, DC: National Academy Press; 1996;
  19. Koh KK, Ahn JY, Choi YM, Han SH, Kim DS, Kim HS, et al. Vascular effects of step I diet in hypercholesterolemic patients with coronary artery disease. Am J Cardiol. 2003;92:708–710
  20. Folch J, Lees M, Sloane Stanley GH. Simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957;226:497–509
  21. Terpstra AHM, Lapre JA, de Vries HT, Beynen AC. Dietary pectin with high viscosity lowers plasma and liver cholesterol concentration and plasma cholesteryl ester transfer protein activity in hamsters. J Nutr. 1998;128:1944–1949
  22. SAS Institute. User’s suide: statistics. Cary, NC: SAS Institute; 1999;
  23. Dobashi K, Ghosh B, Orak JK, Singh I, Singh AK. Kidney ischemia-reperfusion: modulation of antioxidant defenses. Mol Cell Biochem. 2000;205:1–11
  24. Darley-Usmar VM, Hogg N, O’Leary VJ, Wilson MT, Moncada S. The simultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation in human low density lipoprotein. Free Radic Res Commun. 1992;17:9–20
  25. Land W, Schneeberger H, Schleibner S, Illner WD, Abendroth D, Rutili G, et al. The beneficial effect of human recombinant superoxide dismutase on acute and chronic rejection events in recipients of cadaveric renal transplants. Transplantation. 1994;57:211–217
  26. Inal M, Altinisik M, Bilgin MD. The effect of quercetin on renal ischemia and reperfusion injury in the rat. Cell Biochem Funct. 2002;20:291–296
  27. Gurel A, Armutcu F, Sahin S, Sogut S, Ozyurt H, Gulec M, et al. Protective role of alpha-tocopherol and caffeic acid phenethyl ester on ischemia-reperfusion injury via nitric oxide and myeloperoxidase in rat kidneys. Clin Chim Acta. 2004;339:33–41
  28. Jagetia GC, Reddy TK. Modulation of radiation-induced alteration in the antioxidant status of mice by naringin. Life Sci. 2005;77:780–794
  29. Jeon SM, Bok SH, Jang MK, Kim YH, Nam KT, Jeong TS, et al. Comparison of antioxidant effects of naringin and probucol in cholesterol-fed rabbits. Clin Chim Acta. 2002;17:181–190
  30. Yang SX, Diaz Padilla N, Zhu Q, Ma XM, Sasso D, Prestwood K, et al. Estrogen replacement raises rat CRP without evidence of complement activation. Endocr Res. 2005;31:121–132
  31. Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med. 2002;347:1557–1565

 This project is based on work supported by the USDA-CSREES through the Vegetable and Fruit Improvement Center under agreements USDA 2005-34402-14401 and USDA-IFAFS 2001-52102-02294.

PII: S0899-9007(07)00140-2

doi: 10.1016/j.nut.2007.04.009

Nutrition
Volume 23, Issue 7 , Pages 617-621 , July 2007