Nutrition
Volume 23, Issue 5 , Pages 419-423 , May 2007

Effects of Applephenon® and ascorbic acid on physical fatigue

  • Suzuka Ataka, M.D.

      Affiliations

    • Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan
    • The 21st Century COE Program “Base to Overcome Fatigue” (from the Ministry of Education, Culture, Sports, Science and Technology, the Japanese Government), Osaka, Japan
    • ,
  • Masaaki Tanaka, Ph.D.

      Affiliations

    • Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan
    • The 21st Century COE Program “Base to Overcome Fatigue” (from the Ministry of Education, Culture, Sports, Science and Technology, the Japanese Government), Osaka, Japan
    • ,
  • Satoshi Nozaki, Ph.D.

      Affiliations

    • Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan
    • The 21st Century COE Program “Base to Overcome Fatigue” (from the Ministry of Education, Culture, Sports, Science and Technology, the Japanese Government), Osaka, Japan
    • ,
  • Hiroshi Mizuma, Ph.D.

      Affiliations

    • Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan
    • The 21st Century COE Program “Base to Overcome Fatigue” (from the Ministry of Education, Culture, Sports, Science and Technology, the Japanese Government), Osaka, Japan
    • ,
  • Kei Mizuno, Ph.D.

      Affiliations

    • Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan
    • The 21st Century COE Program “Base to Overcome Fatigue” (from the Ministry of Education, Culture, Sports, Science and Technology, the Japanese Government), Osaka, Japan
    • ,
  • Tsuyoshi Tahara, Ph.D.

      Affiliations

    • Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan
    • The 21st Century COE Program “Base to Overcome Fatigue” (from the Ministry of Education, Culture, Sports, Science and Technology, the Japanese Government), Osaka, Japan
    • ,
  • Tomohiro Sugino, M.Sc.

      Affiliations

    • Soiken Incorporation, Osaka, Japan
    • ,
  • Tomoko Shirai, M.Sc.

      Affiliations

    • Soiken Incorporation, Osaka, Japan
    • ,
  • Yoshitaka Kajimoto, Ph.D.

      Affiliations

    • Soiken Incorporation, Osaka, Japan
    • ,
  • Hirohiko Kuratsune, Ph.D.

      Affiliations

    • Department of Health Science, Faculty of Health Science for Welfare, Kansai University of Welfare Sciences, Osaka, Japan
    • ,
  • Osami Kajimoto, Ph.D.

      Affiliations

    • Soiken Incorporation, Osaka, Japan
    • Center for Health Care, Osaka University of Foreign Study, Osaka, Japan
    • ,
  • Yasuyoshi Watanabe, Ph.D.

      Affiliations

    • Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan
    • The 21st Century COE Program “Base to Overcome Fatigue” (from the Ministry of Education, Culture, Sports, Science and Technology, the Japanese Government), Osaka, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-6-6645-3711; fax: +81-6-6645-3712.

Received 21 December 2006 ,Accepted 15 March 2007.

References 

  1. Ream E, Richardson A. Fatigue in patients with cancer and chronic obstructive airways disease: a phenomenological enquiry. Int J Nurs Stud. 1997;34:44–53
  2. Ream E, Richardson A. Fatigue: a concept analysis. Int J Nurs Stud. 1996;33:519–529
  3. Grandjean EP. Fatigue. Am Ind Hyg Assoc J. 1970;31:401–411
  4. Chaudhuri A, Behan PO. Fatigue in neurological disorders. Lancet. 2004;363:978–988
  5. Aprikian O, Busserolles J, Manach C, Mazur A, Morand C, Davicco MJ, et al. Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese Zucker rats. J Nutr. 2002;132:1969–1976
  6. Akazome Y. Characteristics and physiological functions of polyphenols from apples. Biofactors. 2004;22:311–314
  7. Anderson R. Ascorbate-mediated stimulation of neutrophil motility and lymphocyte transformation by inhibition of the peroxidase/H2O2/halide system in vitro and in vivo. Am J Clin Nutr. 1981;34:1906–1911
  8. Anderson R, Oosthuizen R, Maritz R, Theron A, Van Rensburg AJ. The effects of increasing weekly doses of ascorbate on certain cellular and humoral immune functions in normal volunteers. Am J Clin Nutr. 1980;33:71–76
  9. Prinz W, Bortz R, Bregin B, Hersch M. The effect of ascorbic acid supplementation on some parameters of the human immunological defence system. Int J Vitam Nutr Res. 1977;47:248–257
  10. Vallance S. Relationships between ascorbic acid and serum proteins of the immune system. Br Med J. 1977;2:437–438

 This work was supported in part by Special Coordination Funds for Promoting Science and Technology, and the 21st Century COE Program “Base to Overcome Fatigue,” from the Ministry of Education, Culture, Sports, Science and Technology, the Japanese Government.

PII: S0899-9007(07)00091-3

doi: 10.1016/j.nut.2007.03.002

Nutrition
Volume 23, Issue 5 , Pages 419-423 , May 2007

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