Nutrition
Volume 22, Issue 10 , Pages 1039-1044 , October 2006

Arginine-enriched diet limits plasma and muscle glutamine depletion in head-injured rats

  • Christophe Moinard, Ph.D.

      Affiliations

    • Laboratoire de Biologie de la Nutrition, EA2498, Faculté de Pharmacie, Université René Descartes, Paris, France
    • Corresponding Author InformationCorresponding author. Tel.: +33-1-53-73-99-80; fax: +33-1-53-73-99-52.
    • ,
  • Linda Belabed, M.S.

      Affiliations

    • Laboratoire de Biologie de la Nutrition, EA2498, Faculté de Pharmacie, Université René Descartes, Paris, France
    • ,
  • Séverine Gupta, Pharm.D.

      Affiliations

    • Laboratoire de Pharmacie Galénique, EA2498, Faculté de Pharmacie, Université René Descartes, Paris, France
    • ,
  • Valérie Besson, Pharm.D.

      Affiliations

    • Laboratoire de Pharmacologie de la Circulation Cérébrale, EA2510, Faculté de Pharmacie, Université René Descartes, Paris, France
    • ,
  • Catherine Marchand-Verrecchia, Ph.D.

      Affiliations

    • Laboratoire de Pharmacologie de la Circulation Cérébrale, EA2510, Faculté de Pharmacie, Université René Descartes, Paris, France
    • ,
  • Jean-Claude Chaumeil, Pharm.D., Ph.D.

      Affiliations

    • Laboratoire de Pharmacie Galénique, EA2498, Faculté de Pharmacie, Université René Descartes, Paris, France
    • ,
  • Luc Cynober, Pharm.D., Ph.D.

      Affiliations

    • Laboratoire de Biologie de la Nutrition, EA2498, Faculté de Pharmacie, Université René Descartes, Paris, France
    • Service de Biochimie, Hôtel Dieu, AP-HP, Paris, France
    • ,
  • Christine Charrueau, Pharm.D., Ph.D.

      Affiliations

    • Laboratoire de Pharmacie Galénique, EA2498, Faculté de Pharmacie, Université René Descartes, Paris, France

Received 14 November 2005 ,Accepted 7 June 2006.

References 

  1. Mansoor O, Beaufrere B, Boirie Y, Ralliere C, Taillandier D, Aurousseau E, et al. Increased mRNA levels for components of the lysosomal, Ca2+-activated, and ATP-ubiquitin-dependent proteolytic pathways in skeletal muscle from head trauma patients. Proc Natl Acad Sci USA. 1996;93:2714–2718
  2. Mansoor O, Cayol M, Gachon P, Boirie Y, Schoeffler P, Obled C, et al. Albumin and fibrinogen synthesis increase while muscle protein synthesis decreases in head-injured patients. Am J Physiol. 1997;273:E898–E902
  3. Moinard C, Neveux N, Royo N, Genthon C, Marchand-Verrecchia C, Plotkine M, et al. Characterization of the alteration of nutritional state in brain injury induced by fluid percussion in rats. Intensive Care Med. 2005;31:281–288
  4. Parry-Billings P, Evans J, Calder PC, Newsholme EA. Does glutamine contribute to immunosuppression after major burns?. Lancet. 1990;336:523–525
  5. Furst P, Stehle P. Glutamine and glutamine-containing dipeptides. In:  Cynober L editors. Metabolic and therapeutic aspects of amino acids in clinical nutrition. Boca Raton: CRC Press; 2004;p. 613–631
  6. Cynober L. Ornithine α-ketoglutarate. In:  Cynober L editors. Metabolic and therapeutic aspects of amino acids in clinical nutrition. Boca Raton: CRC Press; 2004;p. 633–646
  7. Matthews DE, Marano MA, Campbell RG. Splanchnic bed utilization of glutamine and glutamic acid in humans. Am J Physiol. 1993;264:E848–E854
  8. Berard MP, Zazzo JF, Condat P, Vasson MP, Cynober L. Total parenteral nutrition enriched with arginine and glutamate generates glutamine and limits protein catabolism in surgical patients hospitalized in intensive care units. Crit Care Med. 2000;28:3637–3644
  9. Belabed L, Charrueau C, Gupta S, Besson VC, Walrand S, Marchand-Verrecchia C, et al. Impairment of lymphocyte function in head-injured rats: effects of standard and immune-enhancing diets for enteral nutrition. Clin Nutr. 2006;(in press)
  10. Loi C, Osowska S, Neveux N, Darquy S, Cynober L, Moinard C. Effects of an immune-enhancing diet in endotoxemic rats. Nutrition. 2005;21:255–263
  11. Toulmond S, Duval D, Serrano A, Scatton B, Benavides J. Biochemical and histological alterations induced by fluid percussion brain injury in the rat. Brain Res. 1993;620:24–31
  12. Wilson RF, Dente C, Tyburski JG. The nutritional management of patients with head injuries. Neurol Res. 2001;23:121–128
  13. Martindale RG, Cresci GA. The use of immune enhancing diet in head injury. JPEN. 2001;25:S27–S28
  14. Wakabayashi Y. The glutamate crossway. In:  Cynober L editors. Metabolic and therapeutic aspects of amino acids in clinical nutrition. Boca Raton: CRC Press; 2004;p. 135–152

 This work was presented as a communication at the 26th ESPEN Congress; Lisbon, Portugal; September 2004.This work was supported in part by funds from the French Ministry of Research and Technology (EA2498) and in part by a grant from Nestlé Clinical Nutrition (Noisiel, France).

PII: S0899-9007(06)00245-0

doi: 10.1016/j.nut.2006.06.005

Nutrition
Volume 22, Issue 10 , Pages 1039-1044 , October 2006

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