Nutrition
Volume 22, Issue 6 , Pages 600-608 , June 2006

Associations between hypertriglyceridemia, dietary fat intake, oxidative stress, and endothelial activation in men

  • Charles Couillard, Ph.D.

      Affiliations

    • Institute of Nutraceuticals and Functional Foods, Laval University, Sainte-Foy, Québec, Canada
    • Department of Food Sciences and Nutrition, Laval University, Sainte-Foy, Québec, Canada
    • Corresponding Author InformationCorresponding author. Tel.: +418-656-2131, ext. 12855; fax: +418-656-3423
  • ,
  • Sonia Pomerleau, R.D., M.Sc.

      Affiliations

    • Institute of Nutraceuticals and Functional Foods, Laval University, Sainte-Foy, Québec, Canada
  • ,
  • Guillaume Ruel

      Affiliations

    • Institute of Nutraceuticals and Functional Foods, Laval University, Sainte-Foy, Québec, Canada
  • ,
  • W. Roodly Archer, R.D., M.Sc.

      Affiliations

    • Institute of Nutraceuticals and Functional Foods, Laval University, Sainte-Foy, Québec, Canada
  • ,
  • Jean Bergeron, M.D.

      Affiliations

    • Lipid Research Center, Laval University Medical Center, Sainte-Foy, Québec, Canada
  • ,
  • Patrick Couture, M.D., Ph.D.

      Affiliations

    • Institute of Nutraceuticals and Functional Foods, Laval University, Sainte-Foy, Québec, Canada
    • Lipid Research Center, Laval University Medical Center, Sainte-Foy, Québec, Canada
  • ,
  • Benoît Lamarche, Ph.D.

      Affiliations

    • Institute of Nutraceuticals and Functional Foods, Laval University, Sainte-Foy, Québec, Canada
    • Department of Food Sciences and Nutrition, Laval University, Sainte-Foy, Québec, Canada
  • ,
  • Nathalie Bergeron, Ph.D.

      Affiliations

    • Institute of Nutraceuticals and Functional Foods, Laval University, Sainte-Foy, Québec, Canada

Received 7 June 2005 ,Accepted 13 March 2006.

References 

  1. American Heart Association . Heart disease and stroke statistics—2005 update . Dallas, TX: American Heart Association; 2005;
  2. Assmann G , Schulte H . Relation of high-density lipoprotein cholesterol and triglycerides to incidence of atherosclerotic coronary artery disease (the PROCAM experience). Prospective Cardiovascular Munster study . Am J Cardiol . 1992;70:733–737
  3. Jeppesen J , Hein HO , Suadicani P , Gyntelberg F . Relation of high TG-low HDL cholesterol and LDL cholesterol to the incidence of ischemic heart disease . Arterioscler Thromb Vasc Biol . 1997;17:1114–1120 An 8-year follow-up in the Copenhagen Male Study
  4. Manninen V , Tenkanen L , Koskinen P , Huttunen JK , Manttari M , Heinonen OP , et al.   Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment . Circulation . 1992;85:37–45
  5. Lamarche B , Tchernof A , Moorjani S , Cantin B , Dagenais GR , Lupien PJ , et al.   Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Quebec Cardiovascular Study . Circulation . 1997;95:69–75
  6. Ross R . Atherosclerosis-an inflammatory disease . N Engl J Med . 1999;340:115–126
  7. Rothlein R , Mainolfi EA , Czajkowski M , Marlin SD . A form of circulating ICAM-1 in human serum . J Immunol . 1991;147:3788–3793
  8. Pigott R , Dillon LP , Hemingway IH , Gearing AJ . Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells . Biochem Biophys Res Commun . 1992;187:584–589
  9. Haught WH , Mansour M , Rothlein R , Kishimoto TK , Mainolfi EA , Hendricks JB , et al.   Alterations in circulating intercellular adhesion molecule-1 and L-selectin (further evidence for chronic inflammation in ischemic heart disease) . Am Heart J . 1996;132:1–8
  10. Morisaki N , Saito I , Tamura K , Tashiro J , Masuda M , Kanzaki T , et al.   New indices of ischemic heart disease and aging (studies on the serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) and soluble vascular cell adhesion molecule-1 (VCAM-1) in patients with hypercholesterolemia and ischemic heart disease) . Atherosclerosis . 1997;131:43–48
  11. De Caterina R , Basta G , Lazzerini G , Dell’Omo G , Petrucci R , Morale M , et al.   Soluble vascular cell adhesion molecule-1 as a biohumoral correlate of atherosclerosis . Arterioscler Thromb Vasc Biol . 1997;17:2646–2654
  12. Rohde LE , Lee RT , Rivero J , Jamacochian M , Arroyo LH , Briggs W , et al.   Circulating cell adhesion molecules are correlated with ultrasound-based assessment of carotid atherosclerosis . Arterioscler Thromb Vasc Biol . 1998;18:1765–1770
  13. Ridker PM , Hennekens CH , Roitman-Johnson B , Stampfer MJ , Allen J . Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men . Lancet . 1998;351:88–92
  14. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) . JAMA . 2001;285:2486–2497
  15. Hargrove RL , Etherton TD , Pearson TA , Harrison EH , Kris-Etherton PM . Low fat and high monounsaturated fat diets decrease human low density lipoprotein oxidative susceptibility in vitro . J Nutr . 2001;131:1758–1763
  16. Kratz M , Cullen P , Kannenberg F , Kassner A , Fobker M , Abuja PM , et al.   Effects of dietary fatty acids on the composition and oxidizability of low-density lipoprotein . Eur J Clin Nutr . 2002;56:72–81
  17. Yu-Poth S , Etherton TD , Reddy CC , Pearson TA , Reed R , Zhao G , et al.   Lowering dietary saturated fat and total fat reduces the oxidative susceptibility of LDL in healthy men and women . J Nutr . 2000;130:2228–2237
  18. De Caterina R , Liao JK , Libby P . Fatty acid modulation of endothelial activation . Am J Clin Nutr . 2000;71:213S–223S
  19. Christon RA . Mechanisms of action of dietary fatty acids in regulating the activation of vascular endothelial cells during atherogenesis . Nutr Rev . 2003;61:272–279
  20. Lohman TG , Roche AF , Martorell R . The Airlie (VA) consensus conference . In:  Lohman TG ,  Roche AF ,  Martorell R editor. Anthropometric standardization reference manual . Champaign, IL: Human Kinetics; 1988;p. 39–80
  21. Després JP , Prud’homme D , Pouliot MC , Tremblay A , Bouchard C . Estimation of deep abdominal adipose-tissue accumulation from simple anthropometric measurements in men . Am J Clin Nutr . 1991;54:471–477
  22. Landry N , Bergeron N , Archer R , Samson P , Corneau L , Bergeron J , et al.   Whole-body fat oxidation rate and plasma triacylglycerol concentrations in men consuming an ad libitum high-carbohydrate or low-carbohydrate diet . Am J Clin Nutr . 2003;77:580–586
  23. Moorjani S , Dupont A , Labrie F , Lupien PJ , Brun D , Gagné C , et al.   Increase in plasma high-density lipoprotein concentration following complete androgen blockage in men with prostatic carcinoma . Metabolism . 1987;36:244–250
  24. Burstein M , Samaille J . Sur un dosage rapide du cholesterol lié aux α- et β-lipoprotéines du sérum . Clin Chim Acta . 1960;5:609
  25. St-Pierre AC , Ruel IL , Cantin B , Dagenais GR , Bernard PM , Després JP , et al.   Comparison of various electrophoretic characteristics of LDL particles and their relationship to the risk of ischemic heart disease . Circulation . 2001;104:2295–2299
  26. Holvoet P , Vanhaecke J , Janssens S , Van de Werf F , Collen D . Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease . Circulation . 1998;98:1487–1494
  27. Institute of Medicine of the National Academies . Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids . Washington, DC: National Academies Press; 2002;
  28. Schmidt-Trucksass A , Baumstark MW , Daub C , Espenschied S , Grathwohl D , Berg A . Lipoprotein phenotype and adhesion molecules correlate with diurnal triglyceride profiles in patients with coronary artery disease . Nutr Metab Cardiovasc Dis . 2004;14:20–25
  29. Williams CM , Maitin V , Jackson KG . Triacylglycerol-rich lipoprotein-gene interactions in endothelial cells . Biochem Soc Trans . 2004;32:994–998
  30. Kromhout D , Menotti A , Bloemberg B , Aravanis C , Blackburn H , Buzina R , et al.   Dietary saturated and trans fatty acids and cholesterol and 25-year mortality from coronary heart disease (the Seven Countries Study) . Prev Med . 1995;24:308–315
  31. Nordoy A . Dietary fatty acids and coronary heart disease . Lipids . 1999;34(suppl):S19–S22
  32. Wahrburg U . What are the health effects of fat? . Eur J Nutr . 2004;43(suppl 1):I/6–I/11
  33. Hu FB , Manson JE , Willett WC . Types of dietary fat and risk of coronary heart disease (a critical review) . J Am Coll Nutr . 2001;20:5–19
  34. Fuentes F , Lopez-Miranda J , Sanchez E , Sanchez F , Paez J , Paz-Rojas E , et al.   Mediterranean and low-fat diets improve endothelial function in hypercholesterolemic men . Ann Intern Med . 2001;134:1115–1119
  35. Ambring A , Friberg P , Axelsen M , Laffrenzen M , Taskinen MR , Basu S , et al.   Effects of a Mediterranean-inspired diet on blood lipids, vascular function and oxidative stress in healthy subjects . Clin Sci (Lond) . 2004;106:519–525
  36. Keogh JB , Grieger JA , Noakes M , Clifton PM . Flow-mediated dilatation is impaired by a high-saturated fat diet but not by a high-carbohydrate diet . Arterioscler Thromb Vasc Biol . 2005;25:1274–1279
  37. de Lorgeril M , Salen P , Martin JL , Monjaud I , Delaye J , Mamelle N . Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction (final report of the Lyon Diet Heart Study) . Circulation . 1999;99:779–785
  38. Marckmann P , Gronbaek M . Fish consumption and coronary heart disease mortality. A systematic review of prospective cohort studies . Eur J Clin Nutr . 1999;53:585–590
  39. Harris WS . Fish oils and plasma lipid and lipoprotein metabolism in humans (a critical review) . J Lipid Res . 1989;30:785–807
  40. von Schacky C . N-3 fatty acids and the prevention of coronary atherosclerosis . Am J Clin Nutr . 2000;71:224S–227S
  41. Kang JX , Leaf A . Prevention of fatal cardiac arrhythmias by polyunsaturated fatty acids . Am J Clin Nutr . 2000;71:202S–207S
  42. Brown AA , Hu FB . Dietary modulation of endothelial function (implications for cardiovascular disease) . Am J Clin Nutr . 2001;73:673–686
  43. Ong PJ , Dean TS , Hayward CS , Della Monica PL , Sanders TA , Collins P . Effect of fat and carbohydrate consumption on endothelial function . Lancet . 1999;354:2134
  44. Lussier-Cacan S , Dubreuil-Quidoz S , Roederer G , Leboeuf N , Boulet L , de Langavant GC , et al.   Influence of probucol on enhanced LDL oxidation after fish oil treatment of hypertriglyceridemic patients . Arterioscler Thromb . 1993;13:1790–1797
  45. Oostenbrug GS , Mensink RP , Hornstra G . Effects of fish oil and vitamin E supplementation on copper-catalysed oxidation of human low density lipoprotein in vitro . Eur J Clin Nutr . 1994;48:895–898
  46. Suzukawa M , Abbey M , Howe PR , Nestel PJ . Effects of fish oil fatty acids on low density lipoprotein size, oxidizability, and uptake by macrophages . J Lipid Res . 1995;36:473–484
  47. Turini ME , Crozier GL , Donnet-Hughes A , Richelle MA . Short-term fish oil supplementation improved innate immunity, but increased ex vivo oxidation of LDL in man—a pilot study . Eur J Nutr . 2001;40:56–65
  48. Harats D , Dabach Y , Hollander G , Ben-Naim M , Schwartz R , Berry EM , et al.   Fish oil ingestion in smokers and nonsmokers enhances peroxidation of plasma lipoproteins . Atherosclerosis . 1991;90:127–139
  49. Scheffer PG , Bakker SJ , Popp-Snijders C , Heine RJ , Schutgens RB , Teerlink T . Composition of LDL as determinant of its susceptibility to in vitro oxidation in patients with well-controlled type 2 diabetes . Diabetes Metab Res Rev . 2001;17:459–466
  50. Frankel EN , Parks EJ , Xu R , Schneeman BO , Davis PA , German JB . Effect of n-3 fatty acid-rich fish oil supplementation on the oxidation of low density lipoproteins . Lipids . 1994;29:233–236
  51. Bonanome A , Biasia F , De Luca M , Munaretto G , Biffanti S , Pradella M , et al.   N-3 fatty acids do not enhance LDL susceptibility to oxidation in hypertriacylglycerolemic hemodialyzed subjects . Am J Clin Nutr . 1996;63:261–266
  52. Wander RC , Du SH , Ketchum SO , Rowe KE . Effects of interaction of RRR-alpha-tocopheryl acetate and fish oil on low-density-lipoprotein oxidation in postmenopausal women with and without hormone-replacement therapy . Am J Clin Nutr . 1996;63:184–193
  53. Brude IR , Drevon CA , Hjermann I , Seljeflot I , Lund-Katz S , Saarem K , et al.   Peroxidation of LDL from combined-hyperlipidemic male smokers supplied with omega-3 fatty acids and antioxidants . Arterioscler Thromb Vasc Biol . 1997;17:2576–2588
  54. Higdon JV , Du SH , Lee YS , Wu T , Wander RC . Supplementation of postmenopausal women with fish oil does not increase overall oxidation of LDL ex vivo compared to dietary oils rich in oleate and linoleate . J Lipid Res . 2001;42:407–418
  55. Higgins S , Carroll YL , McCarthy SN , Corridan BM , Roche HM , Wallace JM , et al.   Susceptibility of LDL to oxidative modification in healthy volunteers supplemented with low doses of n-3 polyunsaturated fatty acids . Br J Nutr . 2001;85:23–31

 The study was made possible through a grant from the Canadian Institutes of Health Research. Charles Couillard and Patrick Couture are research scholars of the Fonds de la recherche en santé du Québec (FRSQ). Charles Couillard is also supported by the Chair in Nutrition, Lipidology and Cardiovascular Disease funded by Pfizer Canada and Provigo. Benoît Lamarche is the recipient of a Canada Research Chair in Nutrition, Functional Foods and Cardiovascular Health.

PII: S0899-9007(06)00150-X

doi: 10.1016/j.nut.2006.03.007

Nutrition
Volume 22, Issue 6 , Pages 600-608 , June 2006