Nutrition
Volume 22, Issue 3 , Pages 334-342 , March 2006

Role of partially hydrolyzed guar gum in the treatment of irritable bowel syndrome

Received 5 July 2005 ,Accepted 7 October 2005.

References 

  1. Thompson WG , Longstreth GF , Drossman DA , Heaton KW , Irvine EJ , Muller-Lissner SA . Functional bowel disorders and functional abdominal pain . Gut . 1999;45(suppl 2):43–47
  2. Cash BD , Chey WD . Irritable bowel syndrome—an evidence-based approach to diagnosis . Aliment Pharmacol Ther . 2004;19:1235–1245
  3. Tolliver BA , Herrera JL , DiPalma JA . Evaluation of patients who meet clinical criteria for irritable bowel syndrome . Am J Gastroenterol . 1994;89:176–178
  4. Vanner SJ , Depew WT , Paterson WG , Da Costa LR , Groll AG , Simon JB , et al.   Predictive value of the Rome criteria for diagnosing the irritable bowel syndrome . Am J Gastroenterol . 1999;94:2912–2917
  5. Hasler WL . The irritable bowel syndrome . Med Clin North Am . 2002;86:1525–1551
  6. Barbara G , De Giorgio R , Stanghellini V , Cremon C , Salvioli B , Corinaldesi R . New pathophysiological mechanisms in irritable bowel syndrome . Aliment Pharmacol Ther . 2004;20(suppl 2):1–9
  7. Stanghellini V . International comparative study of the prevalence and impact of gastrointestinal symptoms (an introduction) . Scand J Gastroenterol . 1999;231(suppl):1–2
  8. Chang L , Heitkemper MM . Gender differences in irritable bowel syndrome . Gastroenterology . 2002;123:1686–1701
  9. Drossman DA , Sandler RS , McKee DC , Lovitz AJ . Bowel patterns among subjects not seeking health care. Use of a questionnaire to identify a population with bowel dysfunction . Gastroenterology . 1982;83:529–534
  10. Russo MW , Gaynes BN , Drossman DA . A national survey of practice patterns of gastroenterologists with comparison to the past two decades . J Clin Gastroenterol . 1999;29:339–343
  11. Levy RL , Von Korff M , Whitehead WE , Stang P , Saunders K , Jhingran P , et al.   Costs of care for irritable bowel syndrome patients in a health care maintenance organization . Am J Gastroenterol . 2001;96:3122–3129
  12. Longstreth GF , Wilson A , Knight K , Wong J , Chiou CF , Barghout V , et al.   Irritable bowel syndrome, health care use, and costs (a U.S. managed care perspective) . Am J Gastroenterol . 2003;98:600–607
  13. Delvaux M . Functional bowel disorders and irritable bowel syndrome in Europe . Aliment Pharmacol Ther . 2003;18(suppl 3):75–79
  14. Inadomi JM , Fennerty MB , Bjorkman D . Systematic review (the economic impact of irritable bowel syndrome) . Aliment Pharmacol Ther . 2003;18:671–682
  15. Chang L . Review article (epidemiology and quality of life in functional gastrointestinal disorders) . Aliment Pharmacol Ther . 2004;20(suppl 7):31–39
  16. Koloski NA , Talley NJ , Boyce PM . The impact of functional gastrointestinal disorders on quality of life . Am J Gastroenterol . 2000;95:67–71
  17. Gralnek IM , Hays RD , Kilbourne A , Naliboff B , Mayer EA . The impact of irritable bowel syndrome on health-related quality of life . Gastroenterology . 2000;119:654–660
  18. American College of Gastroenterology Functional Gastrointestinal Disorders Task Force . Evidence-based position statement on the management of irritable bowel syndrome in North America . Am J Gastroenterol . 2002;97(suppl 1):S1–S5
  19. Camilleri M . Review article (clinical evidence to support current therapies of irritable bowel syndrome) . Aliment Pharmacol Ther . 1999;13(suppl 2):48–53
  20. Fennerty MB . Traditional therapies for the irritable bowel syndrome (an evidence-based appraisal) . Rev Gastroenterol Disord . 2003;3(suppl 2):S18–S24
  21. Akehurst R , Kaltenhaler E . Treatment of irritable bowel syndrome (a review of randomised controlled trials) . Gut . 2001;48:272–282
  22. Talley NJ . Pharmacologic therapy for the irritable bowel syndrome . Am J Gastroenterol . 2003;98:750–758
  23. Thompson WG . Irritable bowel syndrome (a management strategy) . Baillieres Best Pract Res Clin Gastroenterol . 1999;13:453–460
  24. Alaimo K , McDowell MA , Briefel RR , Bischf AM , Caughman CR , Loria CM , et al.   Dietary intake of vitamins, minerals and fibers of persons aged 2 months and over in the United States (Third National Health and Nutrition Examination Survey, phase 1, 1988–91) . Adv Data . 1994;258:1–28
  25. Karamanos B , Thanopoulou A , Angelico F , Assad-Khalil S , Barbato A , Del Ben M , et al.   Nutritional habits in the Mediterranean Basin. The macronutrient composition of diet and its relation with the traditional Mediterranean diet. Multi-centre study of the Mediterranean Group for the Study of Diabetes (MGSD) . Eur J Clin Nutr . 2002;56:983–991
  26. Bennett WG , Cerda JJ . Benefits of dietary fibre, myth or medicine? . Postgrad Med . 1996;99:153–175
  27. Paterson WG , Thompson WG , Vanner SJ , Faloon TR , Rosser WW , Birtwhistle RW , et al.   Recommendations for the management of irritable bowel syndrome in general practice . Can Med Assoc J . 1999;161:154–160
  28. Thompson WG , Heaton KW , Smyth GT , Smyth C . Irritable bowel syndrome (the view from general practice) . Eur J Gastroenterol Hepatol . 1997;9:689–692
  29. Janssen HA , Borghouts JA , Muris JW , Metsemakers JF , Koes BW , Knottnerus JA . Health status and management of chronic non-specific abdominal complaints in general practice . Br J Gen Pract . 2000;50:375–379
  30. Muller-Lissner SA . Effect of wheat bran on weight of stool and gastrointestinal transit time (a meta-analysis) . Br Med J . 1988;296:615–617
  31. Talley NJ . Treatment of irritable bowel syndrome . In:  Wolfe MM editors. Therapy of digestive disorders (a comparison to Sleisenger and Fordtran’s gastrointestinal and liver disease) . Philadelphia: WB Saunders; 2000;p. 477–490
  32. Feldman W , McGrath P , Hodgson C , Ritter H , Shipman RT . The use of dietary fiber in the management of simple, childhood, idiopathic, recurrent abdominal pain (results in a prospective, double-blind, randomised, controlled trial) . Am J Dis Child . 1985;138:1216–1218
  33. Hillman LC , Stace NH , Pomare EW . Irritable bowel patients and their long-term response to a high-fiber diet . Am J Gastroenterol . 1984;79:1–7
  34. Stephen AM , Cummings JH . Mechanism of action of dietary fibre in the human colon . Nature . 1980;284:283–284
  35. Bijkerk CJ , Muris JMW , Knotterus JA , Hoes AW , De Wit NJ . Systematic review (the role of different types of fibre in the treatment of irritable bowel syndrome) . Aliment Pharmacol Ther . 2004;19:245–251
  36. Francis CY , Whorwell PJ . Bran and the irritable bowel syndrome (time for a reappraisal) . Lancet . 1994;344:39–40
  37. Mertz HR . Irritable bowel syndrome . N Engl J Med . 2003;349:2136–2146
  38. Jenkins DJ , Goff DV , Leeds AR , Alberti KG , Wolever TM , Gassull MA , et al.   Unabsorbable carbohydrates and diabetes (Decreased post-prandial hyperglycemia) . Lancet . 1976;2:172–174
  39. Jenkins DJ , Leeds AR , Slavin B , Mann J , Jepson EM . Dietary fiber and blood lipids (reduction of serum cholesterol in type II hyperlipidemia by guar gum) . Am J Clin Nutr . 1979;32:16–18
  40. Yamatoya K , Sekiya K , Yamada H . Effects of partially hydrolyzed guar gum on postprandial plasma glucose and lipids levels in humans . J Jpn Soc Nutr Food Sci . 1993;46:199–203
  41. Slavin JL , Greenberg NA . Partially hydrolysed guar gum (clinical nutrition uses) . Nutrition . 2003;19:549–552
  42. Lina BAR . Sub-chronic (13 week) oral toxicity study with Sunfiber and Sunfiber ST in rats . Amsterdam: TNO Nutrition and Food Research Institute; 1997; TNO report V97.080.
  43. Anderson SA , Fischer KD , Talbot JM . Evaluation of the health aspects of using partially hydrolyzed guar gum as a food ingredient . Bethesda, MD: Life Sciences Research Office, Federation of American Societies for Experimental Biology; 1993;
  44. Takahashi H , Yang SI , Hayashi CH , Kim M , Yamanaka J , Yamamoto T . Effect of partially hydrolysed guar gum on fecal output in human volunteers . Nutr Res . 1993;13:649–657
  45. Giaccari S , Grasso G , Tronci S , Allegretta L , Sponziello G , Montefusco A , et al.   Gomma guar parzialmente idrolizzata (una fibra come coadiuvante nella sindrome del colon irritabile) . Clin Ter . 2001;152:21–25
  46. Takahashi H , Wako N , Okubo T , Ishihara N , Yamanaka J , Yamamoto T . Influence of partially hydrolysed guar gum on constipation in women . J Nutr Sci Vitaminol . 1994;40:251–259
  47. Yamatoya K , Kuwano K , Suzuki J , Mitamura T , Sekiya K . Effect of hydrolyzed guar gum on frequency and feeling of defecations in humans . J Appl Glycosci . 1995;42:251–257
  48. Patrick PG , Gohman SM , Marx SC , DeLegge MH , Greenberg NA . Effect of supplements of partially hydrolyzed guar gum on the occurrence of constipation and use of laxative agents . J Am Diet Ass . 1998;98:912–914
  49. Homann HH , Kemen M , Fuessenich C , Senkal M , Zumtobel V . Reduction in diarrhea incidence by soluble fiber in patients receiving total or supplemental enteral nutrition . JPEN . 1994;18:486–490
  50. Alam NH , Meier R , Schneider H , Sarker SA , Bardhan PK , Mahalanabis D , et al.   Partially hydrolized guar gum-supplemented oral rehydration solution in the treatment of acute diarrhea in children . J Pediatr Gastroenterol Nutr . 2000;31:503–507
  51. Spapen H , Diltoer M , Van Malderen C , Opdenacker G , Suys E , Huyghens L . Soluble fiber reduces the incidence of diarrhea in septic patients receiving total enteral nutrition (a prospective, double-blind, randomised, and controlled trial) . Clin Nutr . 2001;20:301–305
  52. Parisi GC , Zilli M , Miani MP , Carrara M , Bottona E , Verdianelli G , et al.   High-fiber diet supplementation in patients with irritable bowel syndrome (IBS). A multicenter, randomized open trial comparison between wheat bran diet and partially hydrolyzed guar gum (PHGG) . Dig Dis Sci . 2002;47:1697–1704
  53. Camilleri M . Management of the irritable bowel syndrome . Gastroenterology . 2001;120:652–668
  54. Hahn BA , Kirchdoerfer LJ , Fullerton S , Mayer E . Patient-perceived severity of irritable bowel syndrome in relation to symptoms, health resource utilization and quality of life . Aliment Pharmacol Ther . 1997;11:553–559
  55. Parisi G , Bottona E , Carrara M , Cardin F , Faedo A , Goldin D , et al.   Treatment effects of partially hydrolyzed guar gum (PHGG) on symptoms and quality of life of patients with irritable bowel syndrome (IBS). A multicenter, randomized open trial . Dig Dis Sci . 2005;50:1107–1112
  56. Svedlund J , Sjödin I , Dotevall G . GSRS. A clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease . Dig Dis Sci . 1988;33:129–134
  57. Ware JE . SF-36 Health Survey. Manual and interpretation guide . Boston: The Health Institute, New England Medical Center; 1993;
  58. Hermann C . International experiences with the Hospital Anxiety and Depression Scale. A review of validation data and clinical results . J Psychosom Res . 1997;42:17–41
  59. Johnston M , Pollard B , Hennessey P . Construct validation of the Hospital Anxiety and Depression Scale with clinical populations . J Psychosom Res . 2000;48:579–584
  60. Gibson GR , Roberfroid MB . Dietary modulation of the human colonic microflora—introducing the concept of prebiotics . J Nutr . 1995;125:1401–1412
  61. Weaver GA , Tangel C , Krause JA , Alpern HD , Jenkins PL , Parfitt MM , et al.   Dietary guar gum alters colonic microbial fermentation in azoxymethane-treated rats . J Nutr . 1996;126:1979–1981
  62. Phillips SF . Physiology and pathophysiology of the colon (relationship to constipation) . In:  Barbara L ,  Corinaldesi R ,  Gizzi G ,  Stanghellini V editor. Chronic constipation . London: WB Saunders; 1996;p. 19–37
  63. Tuohy KM , Kolida S , Lustenberger AM , Gibson GR . The prebiotic effects of biscuits containing partially hydrolysed guar gum and fructo-oligosaccharides—a human volunteer study . Br J Nutr . 2001;86:341–348
  64. Okubo T , Ishihara N , Takahashi H , Fujisawa T , Kim M , Yamamoto T , et al.   Effects of partially hydrolyzed guar gum intake on human intestinal microflora and its metabolism . Biosci Biotechnol Biochem . 1994;58:1364–1369
  65. Nobaek S , Johansson ML , Molin G , Ahrne S , Jeppson B . Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome . Am J Gastroenterol . 2000;95:1231–1238
  66. Saggioro A . Probiotics in the treatment of irritable bowel syndrome . J Clin Gastroenterol . 2004;38(suppl 6):S104–S106

PII: S0899-9007(05)00313-8

doi: 10.1016/j.nut.2005.10.003

Nutrition
Volume 22, Issue 3 , Pages 334-342 , March 2006