Diacylglycerol oil ingestion in type 2 diabetic patients with hypertriglyceridemia

Yamamoto, Kunio; Takeshita, Masao; Tokimitsu, Ichiro; Watanabe, Hiroyuki; Mizuno, Tomohito; Asakawa, Hideki; Tokunaga, Katsuto; Tatsumi, Tatsuya; Okazaki, Mitsuyo; Yagi, Noriko

doi:10.1016/j.nut.2005.04.009

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Volume 22, Issue 1 , Pages 23-29, January 2006

Diacylglycerol oil ingestion in type 2 diabetic patients with hypertriglyceridemia

Kunio Yamamoto, M.S.
- Department of Nutrition, Koshien University, Takarazuka, Hyogo, Japan
Masao Takeshita, M.S.
- Health Care Products Research Laboratories No.1, Kao Corporation, Bunka, Sumida-ku, Tokyo, Japan
- Corresponding author. Tel.: +81-3-5630-7266; fax: +81-3-5630-9436.
Ichiro Tokimitsu, Ph.D.
- Health Care Products Research Laboratories No.1, Kao Corporation, Bunka, Sumida-ku, Tokyo, Japan
Hiroyuki Watanabe, Ph.D.
- Department of Food and Nutritional Science, Toita Women’s College, Shiba, Minato-ku, Tokyo, Japan
Tomohito Mizuno, M.S.
- Biological Science Laboratories, Kao Corporation, Ichikai-machi, Haga-gun, Tochigi, Japan
Hideki Asakawa, M.D., Ph.D.
- Department of Internal Medicine, Suita Municipal Hospital, Suita, Osaka, Japan
Katsuto Tokunaga, M.D., Ph.D.
- Department of Internal Medicine, Itami City Hospital, Itami, Hyogo, Japan
Tatsuya Tatsumi, B.S.
- Department of Nutrition, Itami City Hospital, Itami, Hyogo, Japan
Mitsuyo Okazaki, Ph.D.
- College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Chiba, Japan
Noriko Yagi, Ph.D.
- Department of Nutrition, Koshien University, Takarazuka, Hyogo, Japan

Received 10 January 2005; accepted 26 April 2005. published online 15 November 2005.

Abstract

Objective

Coronary arteriosclerotic heart disease frequently develops in patients with diabetes. Decreased serum high-density lipoprotein cholesterol concentration and low-density lipoprotein (LDL) particle size, accompanied by hypertriglyceridemia, are associated with the onset of atherosclerosis. We recently reported that hypertriglyceridemia was significantly improved in patients with type 2 diabetes who ingested diacylglycerol (DAG) oil. The effect on variables, including LDL particle size related to lipid metabolism, however, was not examined. The present study investigated the effects on these variables in more detail.

Methods

Patients with type 2 diabetes (n = 24) were assigned to receive DAG oil or triacylglycerol oil, and a 3-mo, single-blind, controlled study was performed. Patients replaced cooking oil in their daily diet with DAG or triacylglycerol oil, and anthropometry and blood sampling were performed at monthly intervals.

Results

There were no significant differences in calorie intake or amount of test oil ingested between groups. Waist circumference and serum triacylglycerol concentrations were significantly lower and serum concentrations of high-density lipoprotein cholesterol and apolipoprotein-AI were significantly higher in the DAG oil group than in the triacylglycerol oil group. Plasma plasminogen activator inhibitor-1 concentrations were significantly lower in the DAG oil group. LDL particle size tended to increase in the DAG oil group and was significantly larger in patients who had a small initial LDL particle size (<25.5 nm). There were no significant differences in variables related to glucose metabolism or in serum concentration of free fatty acids or total ketone bodies.