Nutrition
Volume 21, Issue 10 , Pages 994-1002 , October 2005

Homocysteine at pathophysiologic concentrations activates human monocyte and induces cytokine expression and inhibits macrophage migration inhibitory factor expression

  • Shu-Jem Su, Ph.D.

      Affiliations

    • Department of Medical Technology, FooYin University, Kaohsiung, Taiwan
  • ,
  • Li-Wen Huang, Ph.D.

      Affiliations

    • School of Technology for Medical Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan
  • ,
  • Ling-Shiu Pai, M.S.

      Affiliations

    • Department of Biochemistry, Kaohsiung Medical University, Kaohsiung, Taiwan
  • ,
  • Hong-Wen Liu, M.D.

      Affiliations

    • Division of Allergy, Immunology and Rheumatology, Department of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
  • ,
  • Kee-Lung Chang, Ph.D.

      Affiliations

    • Department of Biochemistry, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Corresponding Author InformationCorresponding author. Tel.: +886-7-312-1101, ext. 2306; fax: +886-7-397-2257.

Received 18 October 2004 ,Accepted 31 January 2005.

References 

  1. Ueland PM , Refsum H . Plasma homocysteine, a risk factor for vascular disease (plasma levels in health, disease, and drug therapy) . J Lab Clin Med . 1989;114:473–501
  2. Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, et al. Hyperhomocysteinemia (an independent risk factor for vascular disease) . N Engl J Med . 1991;324:1149–1155
  3. Duell PB , Malinow MR . Homocyst(e)ine (an important risk factor for atherosclerotic vascular disease) . Curr Opin Lipidol . 1997;8:28–34
  4. Welch GN , Loscalzo J . Homocysteine and atherothrombosis . N Engl J Med . 1998;338:1042–1050
  5. Mayer EL , Jacobsen DW , Robinson K . Homocysteine and coronary atherosclerosis . J Am Coll Cardiol . 1996;27:517–527
  6. Gimbrone MA . Vascular endothelium (an integrator of pathophysiologic stimuli in atherosclerosis) . Am J Cardiol . 1995;75:67–70
  7. Yla-Herttuala S , Lipton BA , Rosenfeld ME , Sarkioja T , Yoshimura T , Leonard EJ , et al.   Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions . Proc Natl Acad Sci USA . 1991;88:5252–5256
  8. Poddar R , Sivasubramanian N , DiBello PM , Robinson K , Jacobsen DW . Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells. Implications for vascular disease . Circulation . 2001;103:2717–2723
  9. Pruefer D , Scalia R , Lefer AM . Homocysteine provokes leukocyte–endothelium interaction by downregulation of nitric oxide . Gen Pharmacol . 1999;33:487–498
  10. Ross R . The pathogenesis of atherosclerosis (a perspective for the 1990s) . Nature . 1993;362:801–809
  11. Ross R . Mechanisms of disease (atherosclerosis - an inflammatory disease) . N Engl J Med . 1999;340:115–126
  12. Wick G , Schett G , Albert A , Kleindienst R , Xu Q . Is atherosclerosis an immunologically mediated disease? . Immunol Today . 1995;16:27–33
  13. Jonasson L , Holm J , Skalli O , Bondjers G , Hansson GK . Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque . Arteriosclerosis . 1986;6:131–138
  14. van der Wal AC , Das PK , Bentz van de Berg D , van der Loos CM , Becker AE . Atherosclerotic lesions in humans (in situ immunophenotypic analysis suggesting an immune mediated response) . Lab Invest . 1989;61:166–170
  15. Bendtzen K . Interleukin 1, interleukin 6 and tumor necrosis factor in infection, inflammation and immunity . Immunol Lett . 1988;19:183–191
  16. O’Garra A , Hosken N , Macatonia S , Wenner CA , Murphy K . The role of macrophage- and dendritic cell-derived IL12 in Th1 phenotype development . Res Immunol . 1995;146:466–472
  17. Gerszten RE , Garcia-Zepeda EA , Lim YC , Yoshida M , Ding HA , Gimbrone MA , et al.   MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions . Nature . 1999;398:718–723
  18. Raines EW , Ross R . Smooth muscle cells and the pathogenesis of the lesions of atherosclerosis . Br Heart J . 1993;69:S30–S37
  19. Rus HG , Vlaicu R , Niculescu F . Interleukin-6 and interleukin-8 protein and gene expression in human arterial atherosclerotic wall . Atherosclerosis . 1996;127:263–271
  20. Bernhagen J , Calandra T , Bucala R . Regulation of the immune response by macrophage migration inhibitory factor (biological and structural features) . J Mol Med . 1998;76:151–161
  21. Lue H , Kleemann R , Calandra T , Roger T , Bernhagen J . Macrophage migration inhibitory factor (MIF) (mechanisms of action and role in disease) . Microbes Infect . 2002;4:449–460
  22. Su SJ , Chang KL , Lin TM , Huang YH , Yeh TM . Uromodulin and Tamm-Horsfall protein induce human monocytes to secrete TNF and express tissue factor . J Immunol . 1997;158:3449–3456
  23. Shimizu T , Ohkawara A , Nishihira J , Sakamoto W . Identification of macrophage migration inhibitory factor (MIF) in human skin and its immmunohistochemical localization . FEBS Lett . 1996;381:199–202
  24. Bernhagen J , Calandra T , Mitchell RA , Martin SB , Tracey KJ , Voelter W , et al.   MIF is a pituitary- derived cytokine that potentiates lethal endotoxaemia . Nature . 1993;365:756–759
  25. Calandra T , Bernhagen J , Mitchell RA , Bucala R . The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor . J Exp Med . 1994;179:1895–1902
  26. Khajuria A , Houston DS . Induction of monocytes tissue factor expression by homocysteine (a possible mechanism for thrombosis) . Blood . 2000;96:966–972
  27. Selhub J , Angelo AD . Hyperhomocysteinemia and thrombosis (acquired conditions) . Thromb Haemost . 1997;78:527–531
  28. Lowry SF . Cytokine mediators of immunity and inflammation . Arch Surg . 1993;128:1235–1241
  29. Rollins BJ . Chemokines . Blood . 1997;90:909–928
  30. Koj A . Initiation of acute phase response and synthesis of cytokines . Biochim Biophys Acta . 1996;1317:84–94
  31. Nomikos IN , Vamvakopoulos NC . Correlating functional staging to effective treatment of acute surgical illness . Am J Surg . 2001;182:278–286
  32. Dresch C , Flandrin G , Breton-Gorius J . Phagocytosis of neutrophil polymorphonuclears by macrophages in human bone marrow (importance in granulopoiesis) . J Clin Pathol . 1980;33:1110–1113
  33. Kadri A , Noinuddin M , de Leeuw NK . Phagocytosis of blood cells by splenic macrophages in thrombotic thrombocytopenic purpura . Ann Intern Med . 1975;82:799–802
  34. Saxena U , Goldberg IJ . Endothelial cells and atherosclerosis (lipoprotein metabolism, matrix interactions, and monocyte recruitment) . Curr Opin Lipidol . 1994;5:316–322
  35. Rosenfeld ME , Palinski W , Yla-Herttuala S , Carew TE . Macrophages, endothelial cells, and lipoprotein oxidation in the pathogenesis of atherosclerosis . Toxicol Pathol . 1990;18:560–571
  36. Krishnaswamy G , Kelley J , Yerra L , Smith JK , Chi DS . Human endothelium as a source of multifunctional cytokines (molecular regulation and possible role in human disease) . J Interferon Cytokine Res . 1999;19:91–104
  37. Falk E , Shah PK , Fuster V . Pathogenesis of plaque disruption . In:  Fuster V ,  Ross R ,  Topol EJ editor. Atherosclerosis and coronary artery disease . Volume 2: Philadelphia: Lippincott-Raven; 1996;p. 492–510
  38. Gerrity RG . The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions . Am J Pathol . 1981;103:181–190
  39. Andreotti F , Burzotta F , Mazza A , Manzoli A , Robinson K , Maseri A . Homocysteine and arterial occlusive disease (a concise review) . Cardiologia . 1999;44:341–345
  40. McCully KS . Vascular pathology of homocystinemia (implications for the pathogenesis of arteriosclerosis) . Am J Pathol . 1969;56:111–128
  41. Lentz SR, Sobey CG, Piegors DJ, Bhopatkar MY, Faraci FM, Malinow MR, et al. Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia . J Clin Invest . 1996;98:24–29
  42. Koga T , Claycombe K , Meydani M . Homocysteine increases monocyte and T-cell adhesion to human aortic endothelial cells . Atherosclerosis . 2002;161:365–374
  43. Roth J , Goebeler M , Ludwig S , Wagner L , Kilian K , Sorg C , et al.   Homocysteine inhibits tumor necrosis factor-induced activation of endothelium via modulation of nuclear factor-kappa b activity . Biochim Biophy Acta . 2001;1540:154–165
  44. Demuth K, Atger V, Borderie D, Benoit MO, Sauvaget D, Lotersztajn S, et al. Homocysteine decreases endothelin-1 production by cultured human endothelial cells . Eur J Biochem . 1999;263:367–376
  45. Weijenberg MP , Feskens EJM , Kromhout D . White blood cell count and the risk of coronary heart disease and all-cause mortality in elderly men . Arterioscler Thromb Vasc Biol . 1996;16:499–503
  46. Weiss DJ , Klausner JS . Neutrophil-induced erythrocyte injury (a potential cause of erythrocyte destruction in the anemia associated with inflammatory disease) . Vet Pathol . 1988;25:450–455
  47. Yarnell JW, Baker IA, Sweetnam PM, Bainton D, O’Brien JR, Whitehead PJ, et al. Fibrinogen, viscosity, and white blood cell count are major risk factors for ischemic heart disease. The Caerphilly and Speedwell collaborative heart disease studies . Circulation . 1991;83:836–844
  48. Baugh JA , Bucala R . Macrophage migration inhibitory factor . Crit Care Med . 2002;30:s27–s35
  49. Calandra T , Bernhagen J , Mitchell RA , Bucala R . The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor . J Exp Med . 1994;179:1895–1902
  50. Manetti R, Parronchi P, Giudizi MG, Piccinni MP, Maggi E, Trinchieri G, et al. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4–producing Th cells . J Exp Med . 1993;177:1199–1204
  51. Stary HC , Chandler AB , Glagov S , Guyton JR , Insull W , Rosenfeld ME , et al.   A definition of initial, fatty streak, and intermediate lesions of atherosclerosis (a report from the committee on vascular lesions of the council on arteriosclerosis, American Heart Association) . Circulation . 1994;89:2462–2478

 This study was supported by the National Science Council, Executive Yuan, Taiwan (grants NSC 87-2314-B037-008, NSC 89-2320-B037-069, NSC 91-2314-B-037-270, and KMU-M9317).

PII: S0899-9007(05)00198-X

doi: 10.1016/j.nut.2005.01.011

Nutrition
Volume 21, Issue 10 , Pages 994-1002 , October 2005