Nutrition
Volume 21, Issue 10 , Pages 1003-1009 , October 2005

Dietary nucleotides and human immune cells. II. Modulation of PBMC growth and cytokine secretion

Received 21 October 2004 ,Accepted 24 March 2005.

References 

  1. Ardawi MS , Newsholme EA . Glutamine metabolism in lymphocytes of the rat . Biochem J . 1983;212:835–842
  2. Newsholme P , Gordon S , Newsholme EA . Rates of utilisation and fates of glucose, glutamine, pyruvate, fatty acids and ketone bodies by mouse macrophages . Biochem J . 1987;242:631–636
  3. Carver JD . Dietary nucleotides (cellular immune, intestinal and hepatic system effects) . J Nutr . 1994;124:144S–148S
  4. Carver JD . Dietary nucleotide: effects on the immune and gastrointestinal systems . Acta Paediatr Suppl . 1999;430:83–88
  5. Jyonouchi H . Nucleotide actions on humoral immune responses . J Nutr . 1994;124:138S–143S
  6. Van Buren CT , Kulkarni AD , Rudolph FB . The role of nucleotides in adult nutrition . J Nutr . 1994;124:160S–164S
  7. Rudolph FB , Kulkarni AD , Fanslow WC , Pizzini RP , Kumar S , Van Buren CT . Role of RNA as a dietary source of pyrimidines and purines in immune function . Nutrition . 1990;6:45–52
  8. Kulkarni AD , Fanslow WC , Rudolph FB , Van Buren CT . Effect of dietary nucleotides on response to bacterial infections . JPEN . 1986;10:169–171
  9. Adjei AA , Takamine F , Yokoyama H , Chung SY , Sato L , Shinjo S , et al.  Effect of intraperitoneally administered nucleoside-nucleotide on the recovery from methicillin-resistant Staphylococcus aureus strain 8985 N infection in mice . J Nutr Sci Vitaminol . 1992;38:221–225
  10. Fanslow WC , Kulkarni AD , Van Buren CT , Rudolph FB . Effect of nucleotide restriction and supplementation on resistance to experimental murine candidiasis . JPEN . 1988;12:49–52
  11. Adjei AA , Jones JT , Enriquez FJ , Yamamoto S . Dietary nucleotides and nucleosides reduce Cryptosporidium parvum infection in dexamethasone immunosuppressed adult mice . Exp Parasitol . 1999;92:199–208
  12. Jyonouchi H , Sun S , Winship T , Kuchan MJ . Dietary ribonucleotides modulate type 1 and type 2 T-helper cell responses against ovalbumin in young BALB/cJ mice . J Nutr . 2001;131:1165–1170
  13. Sudo N , Aiba Y , Takaki A , Tanaka K , Yu X-N , Oyama N , et al.  Dietary nucleic acids promote a shift in Th1/Th2 balance toward Th1-dominant immunity . Clin Exp Allergy . 2000;30:979–987
  14. Jyonouchi H , Sun S , Aburi T , Winship T , Huchan MJ . Dietary nucleotides modulate antigen-specific type 1 and type 2 T-cell responses in young C57BL/6 mice . Nutrition . 2000;16:442–446
  15. Sakai M , Taniguchi K , Mamoto K , Ogawa H , Tabata M . Immunostimulant effects of nucleotide isolated from yeast RNA on carp, Cyprinus carpio L . J Fish Dis . 2001;24:433–438
  16. Burrells C , Williams PD , Southgate PJ , Wadsworth SL . Dietary nucleotides: a novel supplement in fish feeds. 2 (Effects on vaccination, salt water transfer, growth rates and physiology of Atlantic salmon (Salmo salar L.)) . Aquaculture . 2001;199:171–184
  17. Pickering LK , Granoff DM , Erickson JR , Masor ML , Cordle CT , Schaller JP , et al.  Modulation of immune system by human milk and infant formula containing nucleotides . Pediatrics . 1998;101:242–249
  18. Jyonouchi H , Zhang L , Tomita Y . Studies on immune modulating actions of RNA/nucleotides (RNA/nucleotides enhance in vitro immunoglobulin production by human peripheral blood mononuclear cells in response to T dependent stimuli) . Pediatr Res . 1993;33:458–465
  19. Jyonouchi H , Sun S . The actions of polynucleotides on effector stage cloned murine T-helper cells differ in each subset and depend on antigen concentration . J Nutr . 1997;127:411–417
  20. Magone MT , Chan C-C , Beck L , Whitcup SM , Raz E . Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitis . Eur J Immunol . 2000;30:1841–1850
  21. Holen E , Jonsson R . Dietary nucleotides and intestinal cell lines: I (Modulation of growth) . Nutr Res . 2004;24:197–207
  22. McCluskie MJ , Davis HL . Oral, intrarectal and intranasal immunisations using CpG and non-CpG oligodeoxynucleotides as adjuvants . Vaccine . 2000;19:413–422
  23. Kobayashi H , Horner AA , Takabayashi K , Nguyen M-D , Huag E , Inman N , et al.  Immunostimulatory DNA prepriming: a novel approach for prolonged Th1 biased immunity . Cell Immunol . 1999;198:69–75
  24. Magnusson M , Magnusson S , Vallin H , Ronnblom L , Alm GV . Importance of CpG dinucleotides in activation of natural IFN-alfa producing cells by a lupus-related oligonucleotide . Scand J Immunol . 2001;54:1–9
  25. Calder PC . Dietary nucleic acids and Th1/Th2 balance: a clue to cow's milk allergy . Clin Exp Allergy . 2000;30:908–910
  26. Lipford GB , Sparwasser T , Bauer M , Zimmermann S , Koch ES , Heeg K , et al.  Immunostimulatory DNA: sequence dependent production of potentially harmful or useful cytokines . Eur J Immunol . 1997;27:3420–3426
  27. Saeij JPJ , Stet RJM , deVries BJ , VanMuisWinkel WB , Wiegertjes GF . Molecular and functional characterisation of carp TNF: a link between TNF polymorphism and trypan tolerance? . Dev Comp Immunol . 2003;27:29–41
  28. Derouich-Guergour D , Brenier-Pinchart MP , Ambroise-Thomas P , Pelloux H . Tumor necrosis factor alpha receptors: role in the physiopathology of protozoan parasite infections . Int J Parasitol . 2001;31:763–769
  29. North RA , Barnard EA . Nucleotide receptors . Curr Opin Neurobipol . 1997;7:346–357
  30. Do EL , Kontani JG , Lowry SF . Nutritional modulation of immunity and the inflammatory response . Nutrition . 1998;14:545–550
  31. Gorodeski GI , Hopfer U , De Santis BJ , Eckert RL , Rorke EA , Utian WH . Biphasic regulation of paracellular permeability in human cervical cells by two distinct nucleotide receptors . Am J Physiol . 1995;268:1215–1226
  32. Marriott I , Inscho EW , Bost KL . Extracellular uridine nucleotides initiate cytokine production by murine dendritic cells . Cell Immunol . 1999;195:147–156
  33. Balimane PV , Sinko PJ . Involvement of multiple transporters in the oral absorption of nucleosides analogues . Adv Drug Deliv . 1999;39:183–209
  34. Liang H , Reich CF , Pisetsky DS , Lipsky PE . The role of cell surface receptors in the activation of human B cells by phosphorothioate oligonucleotides . J Immunol . 2000;165:1438–1445
  35. Jefferies C , O'Neill LAJ . Signal transduction pathway activated by Toll-like receptors . Mod Aspects Immunobiol . 2002;2:169–175
  36. Hemmi H , Takeuchi O , Kawai T , Kaisho T , Sato S , Sanjo H , et al.  A Toll-like receptor recognises bacterial DNA . Nature . 2000;408:740–745
  37. Alexopoulou L , Holt AC , Medzhitov R , Flavell RA . Recognition of double-stranded RNA and activation of NF-kappa by Toll-like receptor 3 . Nature . 2001;413:732–738
  38. Diebold SS , Kaisho T , Hemmi H , Akira S , Reis e Sousa C . Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA . Science . 2004;303:1529–1531
  39. Heil F , Hemmi H , Hochrein H , Ampenberger F , Kirschning C , Akira S , et al.  Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8 . Science . 2004;303:1526–1529
  40. Gelman AE , Zhang J , Choi Y , Turka LA . Toll-like receptor ligands directly promote activated CD4+ T cell survival . J Immunol . 2004;172:6065–6073
  41. Ulevitch RJ . Therapeutics targeting the innate immune system . Nat Rev Immunol . 2004;4:512–520
  42. Hirschfeld M , Weis JJ , Toshchakov V , Salowski CA , Cody MJ , Ward DC , et al.  Signalling by toll-like receptor 2 and 4 agonists' results in differential gene expression in murine macrophages . Inf Immun . 2001;69:1477–1482

 This study was supported by Bjørge Biomarin AS.

PII: S0899-9007(05)00197-8

doi: 10.1016/j.nut.2005.03.003

Nutrition
Volume 21, Issue 10 , Pages 1003-1009 , October 2005