Nutrition
Volume 21, Issue 9 , Pages 940-948 , September 2005

Opposite effects of low and high dose supplementation of vitamin E on survival of MRL/lpr mice

Received 13 July 2004 ,Accepted 30 November 2004.

References 

  1. Watanabe-Fukunage R , Brannan CI , Copeland NG , Jenkins NA , Nagata S . Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis . Nature . 1992;356:314–317
  2. Kotzin BL . Systemic lupus erythematosus . Cell . 1996;85:303–306
  3. Cohen PL , Eisenberg RA . Lpr and gld (single gene models of systemic autoimmunity and lymphoproliferative disease) . Annu Rev Immunol . 1991;9:243–269
  4. Liang HE , Hsueh YP , Wu CC , Hsu SC , Han SH , Lai MZ . Atypical signaling defects prevent IL-2 gene expression in lpr/lpr CD4-CD8- cells . J Biomed Sci . 1998;5:297–304
  5. Takahaski S , Fossati L , Iwamoto M , Merino R , Motta R , Kobayakawa T , et al.   Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice . J Clin Invest . 1996;97:1597–1604
  6. Akahoshi M , Nakashima H , Tanaka Y , Kohsaka T , Nagano S , Ohgami E , et al.   Th1/ Th2 balance of peripheral T helper cells in systemic lupus erythematosus . Arthritis Rheum . 1999;42:1644–1648
  7. Segal R , Bermas BL , Dayan M , Kalush F , Shearer GM , Mozes E . Kinetics of cytokine production in experimental systemic lupus erythematosus . J Immunol . 1997;158:3009–3016
  8. Blount S , Griffiths H , Emery P , Lunec J . Reactive oxygen species modify human DNA, eliciting a more discriminating antigen for the diagnosis of systemic lupus erythematosus . Clin Exp Immunol . 1990;81:384–389
  9. Ruiz-Torres P , Lucio J , González-Rubio M , Rodríguez-Puyol M , Rodríguez-Puyol D . Oxidant antioxidant balance in isolated glomeruli and cultured mesangial cells . Free Radic Biol Med . 1997;22:49–56
  10. Packer L . Protective role of vitamin E in biological systems . Am J Clin Nutr . 1991;53:1050S–1055S
  11. Rock CL , Jacob RA , Bowen PE . Update on the biological characteristics of the antioxidant micronutrients (vitamin C, vitamin E, and the carotenoids) . J Am Diet Assoc . 1996;96:693–702
  12. Meydani SN , Beharka AA . Recent developments in vitamin E and immune response . Nutr Rev . 1996;56:S49–S58
  13. Lee CYJ , Wan JMF . Vitamin E supplementation improves cell-mediated immunity and oxidative stress of men and women . J Nutr . 2000;130:2932–2937
  14. Brigelius-Flohè R , Kelly FJ , Salonen JT , Neuzil J , Zingg JM , Azzi A . The European perspective on vitamin E (current knowledge and future research) . Am J Clin Nutr . 2002;76:703–716
  15. Rimbach G , Minihane AM , Majewicz J , Fischer A , Pallauf J , Virgli F , et al.   Regulation of cell signaling by vitamin E . Proc Nutr Soc . 2002;61:415–425
  16. Comstock GW , Burke AE , Hoffman SC , Helzlsouer KJ , Bendich A , Masi AT , et al.   Serum concentrations of α-tocopherol, β-carotene, and retinol preceding the diagnosis of rheumatoid arthritis and systemic lupus erythematosus . Ann Rheum Dis . 1997;56:323–325
  17. Bae SC , Kim SJ , Sung MK . Impaired antioxidant status and decreased dietary intake of antioxidants in patients with systemic lupus erythematosus . Rheumatol Int . 2002;22:238–243
  18. Venkatraman JT , Chandrasekar B , Kim JD , Fernandes G . Genotype effects on the antioxidant enzymes activity and mRNA expression in liver and kidney tissues of autoimmune-prone MRL/MpJ-lpr/lpr mice . Biochem Biophys Acta . 1994;1213:167–175
  19. Lin BF , Huang CJ , Chiang BL , Jeng SJ . Dietary fat influences Ia antigen expression, cytokines and prostaglandin E2 production of immune cells in autoimmune-prone NZB×NZW F1 mice . Br J Nutr . 1996;75:711–722
  20. Lin BF , Jeng SJ , Chiang BL , Huang CC . Dietary fat affects lipids and anti-cardiolipin antibody levels in autoimmune-prone NZB/W F1 mice . Br J Nutr . 1997;77:657–669
  21. Loizou S , Samarkos M , Norsworthy PJ , Cazabon JK , Walport MJ , Davies KA . Significance of anticardiolipin and anti-β2-glycoprotein I antibodies in lupus nephritis . Rheumatology . 2000;39:962–968
  22. Lin BF , Jeng SJ . Effects of dietary frying oil on lipids and anti-cardiolipin antibody levels in autoimmune-prone NZB/W F1 mice . Nutr Res . 1997;17:1047
  23. Finch JM , Turner RJ . Effects of selenium and vitamin E on the immune responses of domestic animals . Res Veter Sci . 1996;60:97–106
  24. Cooney RV , Maskarinec G , Franke AA , Okinaka L , Karkoszka J , Wilkens LR , et al.   Association of tocopherols with circulating autoantibody levels against an oxidized DNA nucleoside in humans . Free Radic Biol Med . 2001;31:460–468
  25. Wu WM , Suen JL , Lin BF , Chiang BL . Tamoxifen alleviates disease severity and decreases double negative T cells in autoimmune MRL-lpr/lpr mice . Immunology . 2000;100:110–118
  26. Li-Weber M , Giaisi M , Treiber MK , Krammer PH . Vitamin E inhibits IL-4 gene expression in peripheral blood T cells . Eur J Immunol . 2002;32:2401–2408
  27. Beebe AM , Cua DJ , Malefyt RW . The role of interleukin-10 in autoimmune disease (systemic lupus erythematosus (SLE) and multiple sclerosis (MS)) . Cytokine Growth Factor Rev . 2002;13:403–412
  28. Meydani SN , Barklund MP , Liu S , Meydani M , Miller RA , Cannon JG , et al.   Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects . Am J Clin Nutr . 1990;52:557–563
  29. Wang Y , Huang DS , Wood S , Watson RR . Modulation of immune function and cytokine production by various levels of vitamin E supplementation during murine AIDS . Immunopharmacology . 1995;29:225–233
  30. Moriguchi S , Maekawa K , Okamura M , Oonishi K , Kishino Y . Vitamin E prevents the decrease of cellular immune function with aging in spontaneously hypertensive rats . Nutr Res . 1995;15:401
  31. Han SN , Wu D , Ha WK , Beharka A , Smith DE , Bender BS , et al.   Vitamin E supplementation increases T helper 1 cytokine production in old mice infected with influenza virus . Immunology . 2000;100:487–493
  32. Pallast EG , Schouten EG , De Waart FG , Fonk HC , Doekes G , Blomberg BM . Effect of 50- and 100-mg vitamin E supplements on cellular immune function in noninstitutionalized elderly person . Am J Clin Nutr . 1999;69:1273–1281
  33. De Waart FG , Portengen L , Doekes G , Verwaal CJ , Kok FJ . Effect of 3 months vitamin E supplementation on indices of the cellular and humoral immune response in elderly subjects . Br J Nutr . 1997;78:761–774
  34. Kaul N , Devaraj S , Grundy SM , Jialal I . Failure to demonstrate a major anti-inflammatory effect with alpha tocopherol supplementation (400 IU/day) in normal subjects . Am J Cardiol . 2001;87:1320–1323
  35. Payette H , Rola-Pleszczynski M , Ghadirian P . Nutrition factors in relation to cellular and regulatory immune variables in a free-living elderly population . Am J Clin Nutr . 1990;52:927–932
  36. Weimann BJ , Hermann D . Inhibition of autoimmune deterioration in MRL/lpr mice by vitamin E . Inter J Vit Nutr Res . 1999;69:255–261
  37. Venkatraman JT , Chu WC . Effects of dietary ω3 and ω6 lipids and vitamin E on proliferative response, lymphoid cell subsets, production of cytokines by spleen cells, and splenic protein levels for cytokines and oncogenes in MRL/MpJ-lpr/lpr mice . J Nutr Biochem . 1999;10:582–597
  38. Yu W , Sanders BG , Kline K . Modulation of murine EL-4 thymic lymphoma cell proliferation and cytokine production by vitamin E succinate . Nutr Cancer . 1996;25:137–149
  39. Boscoboinik D , Szewczyk A , Hensey C , Azzi A . Inhibition of cell proliferation by α-tocopherol . J Biol Chem . 1991;266:6188–6194
  40. Rimbach G , Minihane AM , Majewicz J , Fischer A , Pallauf J , Virgli F , et al.   Regulation of cell signaling by vitamin E . Proc Nutr Soc . 2002;61:415–425
  41. Liand Q , Verma IM . NF-κB regulation in the immune system . Nature Rev Immunol . 2002;2:725–734
  42. Aringer M . T lymphocyte activation—an inside overview . Acta Med Austriaca . 2002;1:7–13
  43. Davies GF , Mcfie PJ , Khandelwal RL , Roesler WJ . Unique ability of troglitazone to up-regulate peroxisome proliferator-activated receptor-γ expression in hepatocytes . J Pharmacol Exp Ther . 2002;300:72–77
  44. Daynes RA , Jones DC . Emerging roles of PPARs in inflammation and immunity . Nat Rev Immunol . 2002;2:748–759

PII: S0899-9007(05)00170-X

doi: 10.1016/j.nut.2004.11.021

Nutrition
Volume 21, Issue 9 , Pages 940-948 , September 2005

Article Tools

* Image Usage & Resolution