Nutrition
Volume 21, Issue 9 , Pages 933-939 , September 2005

Dietary diacylglycerol reduces postprandial hyperlipidemia and ameliorates glucose intolerance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats

  • Yutaka Mori, M.D., Ph.D.

      Affiliations

    • Department of Internal Medicine, National Hospital Organization, Utsumomiya National Hospital, Tochigi, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-28-673-2111; fax: +81-28-673-6148.
    • ,
  • Hideaki Nakagiri, M.S.

      Affiliations

    • Biological Science Laboratories, Kao Corporation, Tochigi, Japan
    • ,
  • Hidehiko Kondo, Ph.D.

      Affiliations

    • Biological Science Laboratories, Kao Corporation, Tochigi, Japan
    • ,
  • Takatoshi Murase, Ph.D.

      Affiliations

    • Biological Science Laboratories, Kao Corporation, Tochigi, Japan
    • ,
  • Ichiro Tokimitsu, Ph.D.

      Affiliations

    • Biological Science Laboratories, Kao Corporation, Tochigi, Japan
    • ,
  • Naoko Tajima, M.D., Ph.D.

      Affiliations

    • Division of Diabetes and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan

Received 15 October 2004 ,Accepted 11 January 2005.

References 

  1. D’alonzo RP , Kozarek WJ , Wade RL . Glyceride composition of processed fats and oils as determined by glass capillary gas chromatography . Am Oil Chem Soc . 1982;59:292–295
  2. Abdel-Nabey AA , Shehata AAY , Ragab MH , Rossell JB . Glycerides of cottonseed oils from Egyptian and other varieties . Riv Ital Sostanze Grasse . 1992;69:443–447
  3. Nagao T , Watanabe H , Goto N , Onizawa K , Taguchi H , Matsuo N , et al.   Dietary diacylglycerol suppresses accumulation of body fat compared to triacylglycerol in men in double-blind controlled trial . J Nutr . 2000;130:792–797
  4. Maki KC , Davidson MH , Tsushima R , Matsuo N , Tokimitsu I , Umporowicz DM , et al.   Consumption of diacylglycerol oil as part of a reduced-energy diet enhances loss of body weight and fat in comparison with consumption of a triacylglycerol control oil . Am J Clin Nutr . 2002;76:1230–1236
  5. Murase T , Mizuno T , Omachi T , Onizawa K , Komine Y , Kondo H , et al.   Dietary diacylglycerol suppresses high fat and high sucrose diet-induced body fat accumulation in C57BL/6J mice . J Lipid Res . 2001;42:372–378
  6. Meng X , Zou D , Shi Z , Duan Z , Mao Z . Dietary diacylglycerol prevents high-fat diet-induced lipid accumulation in rat liver and abdominal adipose tissue . Lipids . 2004;39:37–41
  7. Murata M , Hara K , Ide T . Alteration by diacylglycerols of the transport and fatty acid composition of lymph chylomicrons in rats . Biosci Biotechnol Biochem . 1994;58:1416–1419
  8. Taguchi H , Watanabe H , Onizawa K , Nagao T , Gotoh N , Yasukawa T . Double-blind controlled study on the effects of dietary diacylglycerol on postprandial serum and chylomicron triacylglycerol responses in healthy humans . J Am Coll Nutr . 2000;19:789–796
  9. Tada N , Watanabe H , Matsuo N , Tokimitsu I , Okazaki M . Dynamics of postprandial remnant-like lipoprotein particles in serum after loading of diacylglycerols . Clin Chim Acta . 2001;311:109–117
  10. Kondo H , Hase T , Murase T , Tokimitsu I . Digestion and assimilation features of dietary DAG in the rat small intestine . Lipids . 2003;38:25–30
  11. Kawano K , Hirashima T , Mori S , Saitoh Y , Kurosumi M , Natori T . Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain . Diabetes . 1992;41:1422–1428
  12. Yamamoto M, Jia DM, Fukumitsu KI, Imoto I, Kihara Y, Hirohata Y, et al. Metabolic abnormalities in the genetically obese and diabetic Otsuka Long-Evans Tokushima Fatty rats can be prevented and reversed by -glucosidase inhibitor . Metabolism . 1999;48:347–354
  13. Jia DM , Tabaru A , Nakamura H , Fukumitsu KI , Akiyama T , Otsuki M . Troglitazone prevents and reverses dyslipidemia, insulin secretory defects, and histologic abnormalities in a rat model of naturally occurring obese diabetes . Metabolism . 2000;249:1167–1175
  14. Hikita M , Bujo H , Yamazaki K , Taira K , Takahashi K , Kobayashi J , et al.   Differential expression of lipoprotein lipase gene in tissues of the rat model with visceral obesity and postprandial hyperlipidemia . Biochem Biophys Res Commun . 2000;277:423–429
  15. Picard F , Boivin A , Lalonde J , Deshaies Y . Resistance of adipose tissue lipoprotein lipase to insulin action in rats fed an obesity-promoting diet . Am J Physiol Endocrinol Metab . 2002;282:E412–E418
  16. Yamamoto K , Asakawa H , Tokunaga K , Watanabe H , Matsuo N , Tokimitsu I , et al.   Long-term ingestion of dietary diacylglycerol lowers serum triacylglycerol in type II diabetic patients with hypertriglyceridemia . J Nutr . 2001;131:3204–3207
  17. Birgitte H-J , Donna RG , Jensen RG . Studies on free and immobilized lipase from Muscor miehei . J Am Oil Chem Soc . 1988;65:905–910
  18. Hara K , Onizawa K , Honda H , Otsuji K , Ide T , Murata M . Dietary diacylglycerol-dependent reduction in serum triacylglycerol concentration in rats . Ann Nutr Metab . 1993;37:185–191
  19. Hultin M , Savonen R , Olivecrona T . Chylomicron metabolism in rats (lipolysis, recirculation of triglyceride-derived fatty acids in plasma FFA, and fate of core lipids as analyzed by compartmental modeling) . J Lipid Res . 1996;37:1022–1036
  20. Taguchi H , Nagao T , Watanabe H , Onizawa K , Matsuo N , Tokimitsu I , et al.   Energy value and digestibility of dietary oil containing mainly 1,3-diacylglycerol are similar to those of triacylglycerol . Lipids . 2001;36:379–382
  21. Clark B , Hubscher G . Biosynthesis of glycerols in the mucosa of the small intestine . Nature . 1960;185:35–37
  22. Clark B , Hubscher G . Biosynthesis of glycerides in subcellular fractions of intestinal mucosa . Biochim Biophys Acta . 1961;46:479–494
  23. Breckenridge WC , Kuksis A . Diacylglycerol biosynthesis in everted sacs of rat intestinal mucosa . Can J Biochem . 1975;53:1170–1183
  24. Paris R , Clement G . Biosynthesis of triglycerides from doubly-labeled 2-monopalmitin in the intestinal mucosa of the rat . Biochim Biophys Acta . 1968;152:63–74
  25. Breckenridge WC , Kuksis A . Triacylglycerol biosynthesis in everted sacs of rat intestinal mucosa . Can J Biochem . 1975;53:1184–1195
  26. Luan Y , Hirashima T , Man ZW , Wang MW , Kawano K , Sumida T . Pathogenesis of obesity by food restriction in OLETF rats-increased intestinal monoacylglycerol acyltransferase activities may be a crucial factor . Diabetes Res Clin Pract . 2000;57:75–82
  27. Man ZW , Hirashima T , Mori S , Kawano K . Decrease in triglyceride accumulation in tissues by restricted diet and improvement of diabetes in Otsuka Long-Evans Tokushima fatty rats, a non-insulin-dependent diabetes model . Metabolism . 2000;49:108–114
  28. Boden G , Chen X . Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes . J Clin Invest . 1995;96:1261–1268
  29. Boden G . Role of fatty acids in the pathogenesis of insulin resistance and NIDDM . Diabetes . 1997;46:3–10
  30. Boden G , Jadali F , White J , Liang Y , Mozzoli M , Chen X , et al.   Effects of fat on insulin-stimulated carbohydrate metabolism in normal men . J Clin Invest . 1991;88:960–966
  31. Roden M , Price TB , Perseghin G , Petersen KF , Rothman DL , Cline GW , et al.   Mechanism of free fatty acid-induced insulin resistance in humans . J Clin Invest . 1996;97:2859–2865
  32. Jequier E . Effect of lipid oxidation on glucose utilization in humans . Am J Clin Nutr . 1998;67:527S–530S
  33. Boden G , Chen X , Ruiz J , White JV , Rossetti L . Mechanisms of fatty acid-induced inhibition of glucose uptake . J Clin Invest . 1994;93:2438–2446
  34. Dresner A , Laurent D , Marcucci M , Griffin ME , Dufour S , Cline GW , et al.   Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity . J Clin Invest . 1999;103:253–259
  35. Maeda K , Okubo K , Shimomura I , Funahashi T , Matsuzawa Y , Matsubara K . cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose most abundant gene transcript 1) . Biochem Biophys Res Commun . 1996;221:286–296
  36. Scherer PE , Williams S , Fogliano M , Baldini G , Lodish HFA . Novel serum protein similar to C1q, produced exclusively in adipocytes . J Biol Chem . 1995;270:26746–26749
  37. Hu E , Liang P , Spiegelman BM . AdipoQ is a novel adipose-specific gene dysregulated in obesity . J Biol Chem . 1996;271:10697–10703
  38. Nakano Y , Tobe T , Choi-Miura NH , Mazda T , Tomita M . Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma . J Biochem (Tokyo) . 1996;120:802–812
  39. Yamauchi T , Kamon J , Waki H , Terauchi Y , Kubota N , Hara K , et al.   The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity . Nat Med . 2001;7:941–946
  40. Kubota N , Terauchi Y , Yamauchi T , Kubota T , Moroi M , Matsui J , et al.   Disruption of adiponectin causes insulin resistance and neointimal formation . J Biol Chem . 2002;277:25863–25866
  41. Maeda N , Shimomura I , Kishida K , Nishizawa H , Matsuda M , Nagaretani H , et al.   Diet-induced insulin resistance in mice lacking adiponectin/ACRP30 . Nat Med . 2002;8:731–737
  42. Rifai N , Ridker PM . High-sensitivity C-reactive protein (a novel and promising marker of coronary heart disease) . Clin Chem . 2001;47:403–411
  43. Cermak J , Key NS , Bach RR , Balla J , Jacob HS , Vercellotti GM . C-Reactive protein induces human peripheral blood monocytes to synthesize tissue factor . Blood . 1993;82:513–520
  44. Wolbink GJ , Brouwer MC , Buysmann S , ten Berge IJ , Hack CE . CRP-mediated activation of complement in vivo (assessment by measuring circulating complement-C-reactive protein complexes) . J Immunol . 1996;157:473–479
  45. Pepys MB , Rowe IF , Baltz ML . C-Reactive protein (binding to lipids and lipoproteins) . Int Rev Exp Pathol . 1985;27:83–111
  46. Papanicolaou DA , Wilder RL , Manolagas SC , Chrousos GP . The pathophysiologic roles of interleukin-6 in human disease . Ann Intern Med . 1998;128:127–137
  47. Jonkers IJ , Mohrschladt MF , Westendorp RG , van der Laarse A , Smelt AH . Severe hypertriglyceridemia with insulin resistance is associated with systemic inflammation (reversal with bezafibrate therapy in a randomized controlled trial) . Am J Med . 2002;112:275–280
  48. Lundman P , Eriksson MJ , Silveira A , Hansson LO , Pernow J , Ericsson CG , et al.   Relation of hypertriglyceridemia to plasma concentrations of biochemical markers of inflammation and endothelial activation (C-reactive protein, interleukin-6, soluble adhesion molecules, von Willebrand factor, and endothelin-1) . Am J Cardiol . 2003;91:1128–1131
  49. Miyasaka K , Kanai S , Ohta M , Kawanami T , Kono A , Funakoshi A . Lack of satiety effect of cholecystokinin (CCK) in a new rat model not expressing the CCK-A receptor gene . Neurosci Lett . 1994;180:143–146
  50. Kanemoto N , Hishigaki H , Miyakita A , Oga K , Okuno S , Tsuji A , et al.   Genetic dissection of “OLETF”, a rat model for non-insulin-dependent diabetic mellitus . Mamm Genome . 1998;9:419–425

PII: S0899-9007(05)00169-3

doi: 10.1016/j.nut.2005.01.009

Nutrition
Volume 21, Issue 9 , Pages 933-939 , September 2005

Article Tools

* Image Usage & Resolution