Nutrition
Volume 21, Issue 3 , Pages 406-410 , March 2005

Effect of folic acid supplementation on aluminum accumulation in rats

  • Terken Baydar, Ph.D.

      Affiliations

    • Department of Toxicology, Faculty of Pharmacy, University of Hacettepe, Ankara, Turkey
    • Corresponding Author InformationCorresponding author. Tel.: +90-312-305-1851; fax: +90-312-311-4777.
  • ,
  • László Nagymajtényi, Ph.D.

      Affiliations

    • Department of Public Health, Faculty of Medicine, University of Szeged, Szeged, Hungary
  • ,
  • Askin Isimer, Ph.D.

      Affiliations

    • Department of Toxicology, Gulhane Military Medicine Academy, Ankara, Turkey
  • ,
  • Gonul Sahin, Ph.D.

      Affiliations

    • Department of Toxicology, Faculty of Pharmacy, University of Hacettepe, Ankara, Turkey
    • Corresponding Author InformationCorresponding author. Tel.: +90-312-305-1851; fax: +90-312-311-4777.

Received 30 December 2003 ,Accepted 1 July 2004.

References 

  1. Davis RE , Nicol DJ . Folic acid . Int J Biochem . 1988;20:133–139
  2. Reisenauer AM , Halsted CH . Human folate requirements . J Nutr . 1987;117:600–602
  3. Blakley RL , Benkovich SJ . Folates and pterins . New York: John Wiley & Sons; 1984;
  4. Picciano MF , Stokstad ELR , Gregory JF . Folic acid metabolism in health and disease . New York: Wiley-Liss; 1990;
  5. Mattson MP . Methylation and acetylation in nervous system development and neurodegenerative disorders . Ageing Res Rev . 2003;2:329–342
  6. Mattson MP , Kruman II , Duan W . Folic acid and homocysteine in age-related disease . Ageing Res Rev . 2002;1:95–111
  7. Martinasevic MK , Rios GR , Miller MW , Tephly TR . Folate and folate-dependent enzymes associated with rat CNS development . Dev Neurosci . 1999;21:29–35
  8. Das UN . Folic acid says NO to vascular diseases . Nutrition . 2003;19:686–692
  9. Solfrizzi V , Panza F , Capurso A . The role of diet in cognitive decline . J Neural Transm . 2003;110:95–110
  10. Young SN . Some effects of dietary components (amino acids, carbohydrate, folic acid) on brain serotonin synthesis, mood, and behaviour . Can J Physiol Pharmacol . 1991;69:893–903
  11. Roe DA . Diet and drug interaction . New York: Van Nostrand Reinhold; 1989;
  12. Ganrot PO . Metabolism and possible health effects of aluminium . Environ Health Perspect . 1986;65:363–441
  13. IPCS . Environmental health criteria 194; aluminium . Geneva: World Health Organization; 1997;
  14. Yokel RA , McNamara PJ . Aluminium toxicokinetics (an updated minireview) . Pharmacol Toxicol . 2001;88:159–167
  15. Nayak P . Aluminum (impacts and disease) . Environ Res . 2002;89:101–115
  16. Lione A . Aluminum toxicology and the aluminum-containing medications . Pharm Ther . 1985;29:255–285
  17. Winship KA . Toxicity of aluminium (a historical review, part 2) . Adverse Drug React Toxicol Rev . 1993;12:177–211
  18. Banks WA , Kastin AJ . Aluminum-induced neurotoxicity (alterations in membrane function at the blood-brain barrier) . Neurosci Biobehav Rev . 1989;13:47–53
  19. Erasmus RT , Savory J , Wills MR , Herman MM . Aluminum neurotoxicity in experimental animals . Ther Drug Monit . 1993;15:588–592
  20. Butterworth CE , Tamura T . Folic acid safety and toxicity (a brief review) . Am J Clin Nutr . 1989;50:353–358
  21. Live animal capture and handling guidelines for wild mammals, birds, amphibians, reptiles. Standards for components of British Columbia’s Biodiversity No. 3. Version 2.0. Vancouver: Ministry of Environment, Lands and Parks Resources Inventory Branch for the Terrestrial Ecosystems Task Force Resources Inventory Committee; December 4, 1998.
  22. Sahin G , Varol I , Temizer A , Benli K , Demirdamar R , Duru S . Determination of aluminum levels in the kidney, liver, and brain of mice treated with aluminum hydroxide . Biol Trace Elem Res . 1994;41:129–135
  23. Sahin G , Isimer A , Temizer A , Sayal A , Sunal R , Duru S . The effect of aluminium loading on bones of mice . Arch Toxicol Suppl . 1991;14:88–91
  24. van Ginkel MF , van der Voet GB , D’Haese PC , De Broe M , de Wolff FA . Effect of citric acid and maltol on the accumulation of aluminium in rat brain and bone . J Lab Clin Med . 1993;121:453–460
  25. Garbossa G , Galvez G , Perez G , Stripeikis J , Tudino M , Nesse A . Oral aluminum administration to rats with normal renal function.2. Body distribution . Hum Exp Toxicol . 1998;17:318–322

 This study was supported by research grant 01.01.301.0003 from Hacettepe University.

PII: S0899-9007(04)00302-8

doi: 10.1016/j.nut.2004.07.008

Nutrition
Volume 21, Issue 3 , Pages 406-410 , March 2005