Nutrition
Volume 19, Issue 3 , Pages 280-281 , March 2003

Potential public health implications of the hypocholesterolemic effects of soy protein

  • Mark J Messina, PhD

      Affiliations

    • Nutrition Matters, Inc., Port Townsend, Washington, USA
    • Loma Linda University, Loma Linda, California, USA
    • Corresponding Author InformationCorrespondence to: Mark J. Messina, PhD, Nutrition Matters, Inc., 439 Calhoun Street, Port Townsend, WA 98368, USA.

References 

  1. Tonstad S, Smerud K, Hoie L. A comparison of the effects of 2 doses of soy protein or casein on serum lipids, serum lipoproteins, and plasma total homocysteine in hypercholesterolemic subjects. Am J Clin Nutr. 2002;76:78
  2. Teixeira SR, Potter SM, Weigel R, et al.  Effects of feeding 4 levels of soy protein for 3 and 6 wk on blood lipids and apolipoproteins in moderately hypercholesterolemic men. Am J Clin Nutr. 2000;71:1077
  3. Anderson JW, Johnstone BM, Cook-Newell ME. Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med. 1995;333:276
  4. Food and Drug Administration . Food labeling, health claims, soy protein, and coronary heart disease. Fed Reg. 1999;57:699
  5. LaRosa JC, He J, Vupputuri S. Effect of statins on risk of coronary disease (a meta-analysis of randomized controlled trials). JAMA. 1999;282:2340
  6. Wong NC. The beneficial effects of plant sterols on serum cholesterol. Can J Cardiol. 2001;17:715
  7. Law MR, Wald NJ, Thompson SG. By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease?. BMJ. 1994;308:367
  8. Nagata C, Takatsuka N, Kurisu Y, Shimizu H. Decreased serum total cholesterol concentration is associated with high intake of soy products in Japanese men and women. J Nutr. 1998;128:209
  9. Ho SC, Woo JL, Leung SS, et al.  Intake of soy products is associated with better plasma lipid profiles in the Hong Kong chinese population. J Nutr. 2000;130:2590
  10. Jenkins DJ, Kendall CW, Vidgen E, et al.  The effect on serum lipids and oxidized low-density lipoprotein of supplementing self-selected low-fat diets with soluble-fiber, soy, and vegetable protein foods. Metabolism. 2000;49:67
  11. Takatsuka N, Nagata C, Kurisu Y, et al.  Hypocholesterolemic effect of soymilk supplementation with usual diet in premenopausal normolipidemic japanese women. Prev Med. 2000;31:308
  12. Shu XO, Jin F, Dai Q, et al.  Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. Cancer Epidemiol Biomarkers Prev. 2001;10:483
  13. Ho SC, Chan SG, Yi Q, Wong E, Leung PC. Soy intake and the maintenance of peak bone mass in Hong Kong Chinese women. J Bone Miner Res. 2001;16:1363
  14. Messina M, Gugger ET, Alekel DL. Soy protein, soybean isoflavones, and bone health (a review of the animal and human data). In:  Wildman R editors. Handbook of nutraceuticals and functional foods. Boca Raton: CRC Press LLC; 2001;p. 77
  15. Arjmandi BH, Smith BJ. Soy isoflavones’ osteoprotective role in postmenopausal women (mechanism of action). J Nutr Biochem. 2002;13:130
  16. Nestel PJ, Yamashita T, Sasahara T, et al.  Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arterioscler Thromb Vasc Biol. 1997;17:3392
  17. Smit E, Nieto FJ, Crespo CJ, Mitchell P. Estimates of animal and plant protein intake in US adults (results from the Third National Health and Nutrition Examination Survey, 1988–1991). J Am Diet Assoc. 1999;99:813
  18. Matvienko OA, Lewis DS, Swanson M, et al.  A single daily dose of soybean phytosterols in ground beef decreases serum total cholesterol and LDL cholesterol in young, mildly hypercholesterolemic men. Am J Clin Nutr. 2002;76:57
  19. US Department of Agriculture . Modification of the Vegetable Protein Products Requirements for the National School Lunch Program, School Breakfast Program, Summer Food Service Program and Child and Adult Care Food Program. CFR parts 210, 215, 220, 225 and 226. Fed Reg. 2000;7:12429

PII: S0899-9007(02)00995-4

doi: 10.1016/S0899-9007(02)00995-4

Nutrition
Volume 19, Issue 3 , Pages 280-281 , March 2003

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