Nutrition
Volume 19, Issue 1 , Pages 21-24 , January 2003

Lutein, but not α-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot study

  • B Olmedilla, PharmD

      Affiliations

    • Unidad de Vitaminas, Sección de Nutrición,, Clínica Puerta de Hierro, Madrid, Spain
    • Corresponding Author InformationCorrespondence to: B. Olmedilla, PharmD, Unidad de Vitaminas, Sección de Nutrición, Clínica Puerta de Hierro, San Martín de Porres, 4, 28035 Madrid, Spain.
    • ,
  • F Granado, PhD

      Affiliations

    • Unidad de Vitaminas, Sección de Nutrición,, Clínica Puerta de Hierro, Madrid, Spain
    • ,
  • I Blanco

      Affiliations

    • Unidad de Vitaminas, Sección de Nutrición,, Clínica Puerta de Hierro, Madrid, Spain
    • ,
  • M Vaquero, MD

      Affiliations

    • Servicio de Oftalmología, Clínica Puerta de Hierro, Madrid, Spain

References 

  1. Varma S. D. (Scientific basis for medical therapy of cataracts by antioxidants). Am J Clin Nutr. 1991;53:3

    35S

  2. Taylor A. Beyond deficiency (new views on the function and health effects of vitamins). Ann NY Acad Sci. 1992;669:111
  3. Bunce GE. Nutrition and eye disease of the elderly. J Nutr Biochem. 1994;5:66
  4. Hankinson SE, Stampfer MJ, Seddon JM. Nutrient intake and cataract extraction in women (a prospective study). BMJ. 1992;305:335
  5. Jacques PF, Chylack LT. Epidemiologic evidence of a role for the antioxidant vitamins and carotenoids in cataract prevention. Am J Clin Nutr. 1991;53:53:352S
  6. Mares-Perlman JA, Brady WE, Klein BE, et al.  Serum carotenoids and tocopherols and severity of nuclear and cortical opacities. Invest Ophthalmol Vis Sci. 1995;36(2):276
  7. Tavani A, Negri E, La Vecchia C. Food and nutrient intake and risk of cataract. Ann Epidemiol. 1996;6:41
  8. Chasan-Traber L, Willett WC, Seddon JM, et al.  A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr. 1999;70:509
  9. Bone RA, Landrum JT, Tarsis SL. Preliminary identification of the human macular pigment. Vis Res. 1985;25:1531
  10. Alvarez RA, Liou GY, Fong S-L, et al.  Levels of α- and γ-tocopherol in human eyes (evaluation of the possible role of IRBP in intraocular α-tocopherol transport). Am J Clin Nutr. 1987;46:481
  11. Bates CJ, Chen S-J, MacDonald A, et al.  Quantitation of vitamin E and a carotenoid pigment in cataractous human lenses and the effect of a dietary supplement. Int J Vitam Nutr Res. 1996;66:316
  12. Yeum K-J, Taylor A, Tang G, et al.  Measurement of carotenoids, retinoids and tocopherols in human lenses. Invest Ophthalmol Vis Sci. 1995;36:2756
  13. Hammond BR, Wooten BR, Snodderly DM. Density of the human crystalline lens is related to the macular pigment carotenoids, lutein and zeaxanthin. Optom Vis Sci. 1997;74:499
  14. Handelman GJ, Dratz EA, Reay CC, et al.  Carotenoids in the human macula and whole retina. Invest Ophthalmol Vis Sci. 1988;29:850
  15. Handelman GJ, Snodderly DM, Adler AJ, et al.  Measurement of carotenoids in human and monkey retinas. Methods Enzymol. 1992;213:220
  16. Hammond BR, Johnson EJ, Russell RM, et al.  Dietary modification of human macular pigment density. Invest Ophthalmol Vis Sci. 1997;38:1795
  17. Landrum JT, Bone RA, Joa H, et al.  A one year study of the macular pigment (the effect of 140 days of a lutein supplement). Exp Eye Res. 1997;65:57
  18. Johnson E, Hammond BR, Yeum K-J, et al.  Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density. Am J Clin Nutr. 2000;71:1555
  19. Olmedilla B, Granado F, Blanco I, et al. Serum status of carotenoids and tocopherols in patients with cataracts: a case-control study. J Nutr Health Ageing 2001;6:66
  20. Olmedilla B, Granado F, Blanco I, Vaquero M, Cajigal C. Lutein in patients with cataracts and age-related macular degeneration (a long-term supplementation study). J Sci Food Agric. 2001;81:904
  21. Olmedilla B, Granado F, Gil-Martínez E, et al.  Reference levels of retinol,α-tocopherol and main carotenoids in serum of control and insulin-dependent diabetic Spanish subjects. Clin Chem. 1997;43:1066
  22. Dereferldt G, Lennestran SG, Wund B. Age variation in normal human contrast sensitivity. Acta Ophthalmol. 1979;57:679
  23. Vaquero M, Encinas JL, Jimenez F. Visual function with monofocal versus multifocal IOLs. J Cataract Refract Surg. 1996;22:1222
  24. Hammond BR, Wooten BR, Curran-Celentano J. Carotenoids in the retina and lens (possible acute and chronic effects on human visual performance). Arch Biochem Biophys. 2001;385:41
  25. Mares-Perlman JA. Too soon for lutein supplements. Am J Clin Nutr. 1999;70:431
  26. Granado F, Olmedilla B, Gil-Martinez E, et al.  Lutein ester in serum after lutein supplementation in humans. Br J Nutr. 1998;80:445

☆ This work was funded by the Fondo de Investigaciones Sanitarias, Spain (FIS 95/1254).

PII: S0899-9007(02)00861-4

Nutrition
Volume 19, Issue 1 , Pages 21-24 , January 2003

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