Nutrition
Volume 19, Issue 3 , Pages 265-269, March 2003

Defective antigen-presenting capacity of murine dendritic cells during starvation

  • Masanori Abe, MD, Sk Md

      Affiliations

    • Third Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
    • ,
  • Fazle Akbar, MD

      Affiliations

    • Third Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
    • ,
  • Bunzo Matsuura, MD

      Affiliations

    • Third Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
    • ,
  • Norio Horiike, MD

      Affiliations

    • Third Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
    • ,
  • Morikazu Onji, MD

      Affiliations

    • Third Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
    • Corresponding Author InformationCorrespondence to: Morikazu Onji, MD, Professor and Chairman, Third Department of Internal Medicine, Ehime University School of Medicine, Shigenobu-cho, Ehime 791-0295, Japan.

Abstract 

Significant impairments of several aspects of immunity have been described in acute and chronic nutritional deficiencies; however, there have been few studies on antigen-presenting cells during starvation. We examined the antigen-presenting capacities of mouse dendritic cells (DCs) from lymphoid organ (spleen DCs) and non-lymphoid tissue (liver DCs) during starvation. The total numbers of spleen DCs and liver DCs were significantly fewer in starved mice than in control mice. Functional analysis showed that the proliferative activities of spleen DCs and liver DCs were significantly impaired in starved mice compared with control mice. In particular, liver DCs from starved mice were unable to induce interferon-γ. Liver DCs from starved mice were unable to induce proliferation of antigen-specific memory lymphocytes. These data indicated that one major cause of impairment of immunologic responses during starvation may be mediated through DCs.

Keywords:  dendritic cells, antigen-presenting cells, starvation, spleen, liver, interleukin-12, interferon-γ

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PII: S0899-9007(02)00854-7

doi:10.1016/S0899-9007(02)00854-7

Nutrition
Volume 19, Issue 3 , Pages 265-269, March 2003

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