Nutrition
Volume 19, Issue 1 , Pages 16-20 , January 2003

Determination of total potentially available nucleosides in human milk from Asian women

  • Randall L Tressler, MD

      Affiliations

    • Abbott Laboratories, Abbott Park, Illinois, USA
    • ,
  • Mary B Ramstack, MS, RD

      Affiliations

    • Abbott Laboratories, Abbott Park, Illinois, USA
    • ,
  • Norman R White, BS

      Affiliations

    • Ross Products Division, Abbott Laboratories, Columbus, Ohio, USA
    • ,
  • Bruce E Molitor, BS

      Affiliations

    • Ross Products Division, Abbott Laboratories, Columbus, Ohio, USA
    • ,
  • Nancy R Chen, MS, RD
    • ,
  • Pedro Alarcon, MD, PhD

      Affiliations

    • Abbott Laboratories, Abbott Park, Illinois, USA
    • Corresponding Author InformationCorrespondence to: Pedro Alarcon, MD, PhD, Abbott Laboratories, 200 Abbott Park Road, D-R4NH, AP30-2, Abbott Park, IL 60064-6149, USA.
    • ,
  • Marc L Masor, PhD

      Affiliations

    • Ross Products Division, Abbott Laboratories, Columbus, Ohio, USA

References 

  1. Rodwell VW. Structure, function, replication of informational macromolecules. In:  Murray RK,  Granner DK,  Mayes PA,  Rodwell VW editor. Harper’s biochemistry. Norwalk, CT: Appleton & Lange; 1993;p. 353
  2. Barness LA. Dietary sources of nucleotides—from breast milk to weaning. J Nutr. 1994;124(suppl):128S
  3. Carver JD, Walker WA. The role of nucleotides in human nutrition. J Nutr Biochem. 1995;6:58
  4. Rodwell VW. Metabolism of purine and pyrimidine nucleotides. In:  Murray RK,  Granner DK,  Mayes PA,  Rodwell VW editor. Harper’s biochemistry. Norwalk, CT: Appleton & Lange; 1993;p. 363
  5. Uauy R, Stringel G, Thomas R, et al.  Effect of dietary nucleosides on growth and maturation of the developing gut in the rat. J Pediatr Gastroenterol Nutr. 1990;10:497
  6. Uauy R, Quan R, Gil A. Role of nucleotides in intestinal development and repair (implications for infant nutrition). J Nutr. 1994;124(suppl):14

    36S

  7. Carver JD. Dietary nucleotides (cellular immune, intestinal, and hepatic system effects). J Nutr. 1994;124(suppl):1

    44S

  8. Kulkarni AD, Fanslow WC, Rudolph FB, et al.  Effect of dietary nucleotides on response to bacterial infections. JPEN. 1986;10:169
  9. Rudolph FB, Van Burren CT. The metabolic effects of enterally administered ribonucleic acids. Curr Opin Clin Nutr Metab Care. 1998;1:527
  10. Carver JD. Dietary nucleotides (effects on the immune and gastrointestinal systems). Acta Paediatr. 1999;88(suppl):83
  11. Kuchan M, Winship T, Masor M. Nucleotides in infant nutrition (effects on immune function). In:  Reifen R,  Lerner A,  Branski D,  Heymans HAS editor. Pediatric nutrition. Pediatric adolescent medicine. Vol 8:Basel: Karger; 1998;p. 80
  12. Grimble GK, Westwood OM. Nucleotides as immunomodulators in clinical nutrition. Curr Opin Clin Nutr Metab Care. 2001;4:57
  13. Kobata A, Ziro S, Kida M. The acid-soluble nucleotides of milk. IV. The chemical structure of UDP-X3. J Biochem (Tokyo). 1966;59:63
  14. Johke T. Acid-soluble nucleotides of colostrum, milk, and mammary gland. J Biochem. 1963;54:388
  15. Dewey KG, Heinig MJ, Nommsen-Rivers LA. Differences in morbidity between breast-fed and formula-fed infants. J Pediatr. 1995;126:696
  16. Martinez-Augustin O, Boza JJ, Navarro J, et al.  Dietary nucleotides may influence the humoral immunity in immunocompromised children. Nutrition. 1997;13:465
  17. Brunser O, Espinoza J, Araya M, et al.  Effect of dietary nucleotide supplementation on diarrhoeal disease in infants. Acta Paediatr. 1994;83:188
  18. Cosgrove M, Davies DP, Jenkins HR. Nucleotide supplementation and the growth of term small for gestational age infants. Arch Dis Child Fetal Neonatal Ed. 1996;74:F122
  19. Gil A, Sanchez-Medina F. Acid-soluble nucleotides of human milk at different stages of lactation. J Dairy Res. 1982;49:301
  20. Janas LM, Picciano MF. The nucleotide profile of human milk. Pediatr Res. 1982;16:659
  21. Leach JL, Baxter JH, Molitor BE, et al.  Total potentially available nucleosides of human milk by stage of lactation. Am J Clin Nutr. 1995;61:1224
  22. Pickering LK, Granoff DM, Erickson JR, et al.  Modulation of the immune system by human milk and infant formula containing nucleotides. Pediatrics. 1998;101:242
  23. Schaller JP, Wheeler JG, Thomas DL, et al. Vaccine response in infants fed formula containing nucleotides. Paper presented at the 14th NASPGN Annual Meeting, Orlando, Florida, October 25–28, 2001.
  24. Buck RH, Thomas DL, Winship TR, et al. Dietary nucleotides enhance immune cell maturation in infants. Paper presented at the 14th NASPGN Annual Meeting, Orlando, Florida, October 25–28, 2001.
  25. Yau K, Huang C, Chen W, et al. Effect of a nucleotide-fortified infant formula on immune response. Paper presented at the World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Boston, Massachusetts, August 5–9, 2000
  26. Thorell L, Sjoberg L-B, Hernell O. Nucleotides in human milk (sources and metabolism by the newborn infant). Pediatr Res. 1996;40:845

☆ This research supported by Abbott Laboratories, Abbott Park, Illinois.

PII: S0899-9007(02)00843-2

Nutrition
Volume 19, Issue 1 , Pages 16-20 , January 2003

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