Nutrition
Volume 19, Issue 1 , Pages 1-6 , January 2003

Glutamine attenuates tumor necrosis factor-α release and enhances heat shock protein 72 in human peripheral blood mononuclear cells

  • Paul E Wischmeyer, MD

      Affiliations

    • Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    • Corresponding Author InformationCorrespondence to: Paul E. Wischmeyer, MD, Department of Anesthesiology, University of Colorado Health Sciences Center, Box B-113, 4200 E. 9th Avenue, Denver, CO 80262, USA.
    • ,
  • Jacob Riehm

      Affiliations

    • Department of Medicine, Martin Boyer Laboratories, Chicago, Illinois, USA
    • ,
  • Kristen D Singleton, BS

      Affiliations

    • Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    • ,
  • Hongyu Ren, MD

      Affiliations

    • Department of Medicine, Martin Boyer Laboratories, Chicago, Illinois, USA
    • ,
  • Mark W Musch, MD

      Affiliations

    • Department of Medicine, Martin Boyer Laboratories, Chicago, Illinois, USA
    • ,
  • Madelyn Kahana, MD

      Affiliations

    • Department of Anesthesia and Critical Care, and the Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
    • ,
  • Eugene B Chang, MD

      Affiliations

    • Department of Medicine, Martin Boyer Laboratories, Chicago, Illinois, USA

References 

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  3. Wischmeyer PE, Kahana MD, Wolfson R, et al.  Glutamine reduces cytokine release, organ damage, and mortality in a rat model of endotoxemia. Shock. 2001;16:398
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  5. Chang W, Yang KD, Shaio M. Effect of glutamine on Th1 and Th2 cytokine responses of human peripheral blood mononuclear cells. Clin Immunol. 1999;93:294
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  7. Wischmeyer PE, Musch MW, Madonna MB, et al.  Glutamine protects intestinal epithelial cells (role of inducible HSP 70). Am J Physiol. 1997;272:G879
  8. Wischmeyer PE, Kahana MD, Wolfson R, et al.  Glutamine induces heat shock protein and protects against endotoxin shock in the rat. J Appl Physiol. 2001;90:2403
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  14. De Beaux A, O’Riordan M, Ross J, et al.  Glutamine-supplemented total parenteral nutrition reduces blood mononuclear cell interleukin-8 release in severe acute pancreatitis. Nutrition. 1998;14:261
  15. Wong H, Ryan M, Wispe JR. Stress response decreases NF-κB nuclear translocation and increases I-κβα expression in A549 cells. J Clin Invest. 1997;99:2423
  16. Chang WG, Yank YD, Shaio MF. Effect of glutamine on Th1 and Th2 cytokine responses of human peripheral blood mononuclear cells. Clin Immunol. 1999;93:294
  17. Lacey JM, Wilmore DW. Is glutamine a conditional essential amino acid?. Nutr Rev. 1990;48:297
  18. Newsholme EA, Crabtree B, Ardawi MSM. The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells. Biosci Rep. 1985;5:393
  19. Askanazi J, Carpentier YA, Michelsen CB, et al.  Muscle and plasma amino acids following injury. Ann Surg. 1980;192:78
  20. Ziegler TR, Young LS, Benfell K, et al.  Clinical and metabolic efficacy of glutamine supplemented parental nutrition after bone marrow transplantation. Ann Intern Med. 1992;16:821
  21. Giffiths RD, Jones C, Palmer TE. Six-month outcome of critically ill patients given glutamine supplemented parenteral nutrition. Nutrition. 1997;13:295
  22. Neu J, Roig JC, Meetze WH, et al.  Enteral glutamine supplementation for very low birth weight infants decreases morbidity. J Pediatr. 1997;131:691
  23. Houdijk APJ, Rijnsburger ER, Jansen J, et al.  Randomized trial of glutamine-enriched nutrition on infectious morbidity in patients with multiple trauma. Lancet. 1998;352:772
  24. Wischmeyer PE, Liedel JL, Lynch J, et al.  Glutamine reduces gram negative bacteremia in severely burned patients. Crit Care Med. 2001;29:2075

☆ This work was supported by the National Institute of Diabetes, Digestive and Kidney Disease grants DK38510 and DK 47722, Digestive Disease Core grant DK-42086, and Crohn’s and Colitis Foundation of America Research (E.B.C.), and the Foundation for Anesthesia Education and Research (P.E.W.).

PII: S0899-9007(02)00839-0

Nutrition
Volume 19, Issue 1 , Pages 1-6 , January 2003

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