Nutrition
Volume 17, Issue 10 , Pages 797-798 , October 2001

The genetic basis of vitamin e deficiency in humans

  • Herbert J. Kayden, MD

      Affiliations

    • Department of Medicine, New York University School of Medicine, New York, New York, USA
    • Corresponding Author InformationCorrespondence to: Herbert J. Kayden, MD, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA

,Accepted 1 June 2001.

References 

  1. Kayden HJ, Silber R. The role of vitamin E deficiency in the abnormal autohemolysis of acanthocytosis. Trans Assoc Am Phys. 1965;78:334
  2. Bjornson LK, Kayden HJ, Miller E, Moshell AN. The transport of α-tocopherol and β-carotene in human blood. J Lipid Res. 1976;17:343
  3. Kayden HJ, Hatam LJ, Traber MG. The measurement of nanograms of tocopherol from needle aspiration biopsies of adipose tissue (normal and abetalipoproteinemic subjects). J Lipid Res. 1983;24:652
  4. Gregg RE, Wetterau JR. The molecular basis of abetalipoproteinemia. Curr Opin Lipidol. 1994;5:81
  5. Traber MG, Kayden HJ. Preferential incorporation of α-tocopherol vs γ-tocopherol in human lipoproteins. Am J Clin Nutr. 1989;49:517
  6. Traber MG, Rudel LL, Burton GW, et al.  RRR- and SRR-α-tocopherols are secreted without discrimination in human chylomicrons, but RRR-α-tocopherol is preferentially secreted in very low density lipoproteins. J Lipid Res. 1990;31:675
  7. Traber MG, Sokol RJ, Burton GW, et al.  Impaired ability of patients with familial isolated vitamin E deficiency to incorporate α-tocopherol into lipoproteins secreted liver. J Clin Invest. 1990;85:397
  8. Sato Y, Hagiwara K, Arai H, Inoue K. Purification and characterization of the α-tocopherol transfer from rat liver. FEBS Lett. 1991;288:41
  9. Ben Hamida M, Belal S, Sirugo C, et al.  Friedreich’s ataxia phenotype not linked to chromosome 9 and associated with selective autosomal recessive vitamin E deficiency in two inbred Tunisian families. Neurology. 1993;43:2179
  10. Ouahchi K, Artia M, Kayden H, et al.  Ataxia with isolated vitamine E deficiency is caused by mutations in the α-tocopherol transfer protein. Nat Genet. 1995;9:141
  11. Kayden HJ, Traber MG. Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans. J Lipid Res. 1993;34:343
  12. Copp RP, Wisniewski T, Hentati F, et al. Localization of α-tocopherol transfer protein in the brains of patients with ataxia with vitamin E deficiency and other oxidative stress related neurodegenerative disorders. Brain Res 1999;822:80

PII: S0899-9007(01)00650-5

Nutrition
Volume 17, Issue 10 , Pages 797-798 , October 2001

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