Nutrition
Volume 17, Issue 10 , Pages 828-834 , October 2001

Antioxidant mobilization in response to oxidative stress: a dynamic environmental–nutritional interaction

  • Nabil M. Elsayed, PhD

      Affiliations

    • New Products Research, GlaxoSmithKline, Consumer Healthcare, Parsippany, New Jersey, USA
    • Corresponding Author InformationCorrespondence to: Nabil M. Elsayed, PhD, New Products Research, GlaxoSmithKline, Consumer Healthcare, 1500 Littleton Road, Parsippaney, NJ 07054-3884, USA

,Accepted 1 June 2001.

References 

  1. Raloff J. Fight ozone with a breath of vitamin E?. Science. 1984;1125:197
  2. Elsayed NM. Mobilization of vitamin E to the lung under oxidative stress. Ann NY Acad Sci. 1989;570:439
  3. Elsayed NM. , Mustafa MG, Mead JF. Increased vitamin E content in the lung after ozone exposure: a possible mobilization in response to oxidative stress. Arch Biochem Biophys. 1990;282::263
  4. Sies H. Oxidative stress (introductory remarks). In:  Sies H editors. Oxidative stress. London: Academic Press; 1985;p. 1
  5. Flohe’ L, Beckmann R, Giertz H, Loschen G. Oxygen-centered free radicals as mediators of inflammation. In:  Sies H editors. Oxidative stress. London: Academic Press; 1985;p. 403
  6. Murray JF. The normal lung. Philadelphia: WB Saunders; 1976;
  7. Clark JM, Lambertsen CJ. Pulmonary oxygen toxicity. A review. Pharmacol Rev. 1971;23:37
  8. Mustafa MG, Tierney DF. Biochemical and metabolic changes in the lung with oxygen, ozone, and nitrogen dioxide toxicity. Am Rev Respir Dis. 1978;118:1061
  9. Evans HM, Burr GO. The anti-sterility vitamine fat soluble E. Proc Natl Acad Sci USA. 1925;11:334
  10. Tappel AL. Vitamin E as the biological lipid antioxidant. Vitam Horm. 1962;20:493
  11. Tappel AL. Free-radical lipid peroxidation damage and its inhibition by vitamin E and selenium. Fed Proc. 1965;24:73
  12. Witting LA. Vitamin E and lipid antioxidants in free-radical-initiated reactions. In:  Pryor WA editors. Free radicals in biology, Vol 4. New York: Academic Press; 1980;p. 295
  13. Tappel A. Vitamin E and free radical peroxidation of lipids. Ann NY Acad Sci. 1972;202:29
  14. Green J. Vitamin E and the biological antioxidant theory. Ann NY Acad Sci. 1972;202:29
  15. Chow CK, Tappel AL. An enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats. Lipids. 1972;7:518
  16. Mustafa MG. Influence of dietary vitamin E on lung cellular sensitivity to ozone in rats. Nutr Rep Int. 1975;11:473
  17. Dillard CJ, Litov RE, Savin WM, Dumelin EE, Tappel AL. Effect of exercise, vitamin E, and ozone on pulmonary function and lipid peroxidation. J Appl Physiol. 1978;45:927
  18. Elsayed NM, Mustafa MG. Dietary antioxidants and the biochemical response to oxidant inhalation. I. Influence of dietary vitamin E on the biochemical effects of nitrogen dioxide exposure in rat lung. Toxicol Appl Pharmacol. 1982;66:319
  19. Elsayed NM, Hacker AD, Kuehn K, Mustafa MG, Schrauzer GN. Dietary antioxidants and the biochemical response to oxidant inhalation II. Influence of dietary selenium on the biochemical effects of ozone exposure in mouse lung. Toxicol Appl Pharmacol. 1983;71:398
  20. Elsayed NM. Influence of vitamin E on polyamine metabolism in ozone-exposed rat lungs. Arch Biochem Biophys. 1987;255:392
  21. Chow CK, Airriess GR, Chen L-C, Changchit C. Vitamin C levels in tissues of cigarette-smoked guinea pigs and rats. Annal NY Acad Sci. 1987;498:467
  22. Chow CK. Vitamin E and cigarette smoking-induced oxidative damage. In:  Packer L,  Fuchs J editor. Vitamin E in health and disease. New York: Marcel Dekker; 1993;p. 683
  23. Avunduk AM, Yardimci S, Avunduk MC, et al.  Prevention of lens damage associated with cigarette smoke exposure in rats by α-tocopherol (vitamin E) treatment. Invest Opthalmol Vis Sci. 1999;40:537
  24. Harumi J, Sun S, Mizokami M, Ingbar DH. Cell density and antioxidant vitamins determine the effects of hyperoxia on proliferation and death of MDCK epithelial cells. Nutr Cancer. 1997;28:115
  25. Tolle A, Kolleck I, Schlame M, et al.  Effect of hyperoxia on the composition of the alveolar surfactant and the turnover of surfactant phospholipids, cholesterol, plasmalogens, and vitamin E. Biochim Biophys Acta. 1997;1346:198
  26. Rock CL, Dechert RE, Khilnani R, Parker RS, Rodriguez JL. Carotenoids and antioxidant vitamins in patients after burn injury. J Burn Care Rehabil. 1997;18:269
  27. Di Prampero PE. Energetics of muscular exercise. Rev Physiol Biochem Pharmacol. 1981;96:143
  28. Davies KJA, Quintanilha AT, Brooks GA, Packer L. Free radicals and tissue damage produced by exercise. Biochem Biophys Res Commun. 1982;107:1198
  29. Pincemail J Deby C, Camus G, et al.  Tocopherol mobilization during intensive exercise. Eur J Appl Physiol. 1988;57:189
  30. Bus JS, Gibson JE. Paraquat. Model for oxidant initiated toxicity. Environ Health Perspect. 1984;55:37
  31. Suntres ZE, Shek PN. The pulmonary uptake of intravenously administered liposomal alpha-tocopherol is augmented in acute lung injury. J Drug Target. 1996;4:151
  32. Bismuth C, Garnier R, Baud FJ, Muszynski J, Keys C. Paraquat poisoning (an overview of the status). Drug Saf. 1990;5:243
  33. Azevedo LCP, Pedro Mde A, Souza LC, et al.  Oxidative stress as a signaling mechanism of the vascular response to injury (the redox hypothesis of restenosis). Cardiovasc Res. 2000;47:436
  34. Palace VP, Hill MF, Farahmand F, Singal PK. Mobilization of antioxidant vitamin pools and hemodynamic function after myocardial infarction. Circulation. 1999;99:121
  35. Warren DL, Reed DJ. Modification of hepatic vitamin E stores in vivo. I. Alterations in plasma and liver vitamin E content by methyl ethyl ketone peroxide. Arch Biochem Biophys. 1991;285:45
  36. Rocchi E, Casalgrandi G, Ronzoni A, et al.  Antioxidant liposoluble vitamins and carotenoids in chronic hepatitis. Eur J Intern Med. 2001;12:116
  37. World Health Organization . Health hazards of the human environment. Geneva: World Health Organization; 1972;
  38. Haagen Smit AJ. Chemistry and physiology of Los Angeles smog. Indian Engin Chem. 1952;44:1342
  39. Sagai M, Ichinose T, Oda H, Kubota K. Studies on biochemical effects of nitrogen dioxide. II. Changes of the protective systems in rat lungs and of lipid peroxidation by acute exposure. J Toxicol Environ Health. 1982;9:153
  40. Elsayed NM. Modulation of pulmonary vitamin E by environmental oxidants. In:  Packer L,  Fuchs J editor. Vitamin E (biochemistry and clinical applications). New York: Marcel Dekker; 1993;p. 699
  41. Elsayed NM, Mustafa MG, Hacker AD, Kuehn K, Schrauzer GN. Dietary antioxidants and the biochemical response to oxidant inhalation. III. Influence of dietary selenium on mouse lung response and tolerance to ozone. Biol Trace Elem Res. 1984;6:249
  42. Muller B, Hochscheid R, Seifart C, Barth PJ. Alpha-tocopherol improves impaired physiology of rat type II pneumocytes isolated from experimentally injured lungs. Eur J Clin Invest. 2000;30:1018
  43. Last JA, Gerriets JE, Hyde DM. Synergistic effects on rat lungs of mixtures of oxidant air pollutants (ozone or nitrogen dioxide) and respirable aerosols. Am Rev Respir Dis. 1983;128:539
  44. Mustafa MG, Elsayed NM, von Dohlen FM, et al.  A comparison of biochemical effects of nitrogen dioxide, ozone, and their combination in mouse lung. I. Intermittent exposures. Toxicol Appl Pharmacol. 1984;72:82
  45. Sagai M. Biochemical effects on combined gases of nitrogen dioxide and ozone. III. Synergistic effects on lipid peroxidation and antioxidative protective systems in the lungs of rats and guinea pigs. Toxicology. 1989;59:259
  46. Rajini P, Gelzleichter TR, Last JA, Witschi H. Alveolar and airway cell kinetics in the lungs of rats exposed to nitrogen dioxide, ozone, and a combination of the two gases. Toxicol Appl Pharmacol. 1993;121:186
  47. Elsayed NM, Kass RA, Mustafa MG, et al.  Effect of dietary vitamin E level on rat lung response to ozone inhalation. Drug Nutr Interact. 1988;5:373
  48. Elsayed NM, Kuehn K, Schrauzer GN, Mustafa MG. Selenium deficiency increases mortality, and potentiates extrapulmonary hepatic response to inhaled ozone. Environ Nutr Interact. 1997;1:23
  49. Suzuki YJ, Forman HJ, Sevanian A. Oxidants as simulators of signal transduction. Free Radic Biol Med. 1997;22:269
  50. Travers JB. Oxidative stress can activate the epidermal platelet-activating factor receptor. J Invest Dermatol. 1999;112:279
  51. Evans MJ. Cell death and cell renewal in small airways and alveoli. In:  Witschi H,  Nettesheim P editor. Mechanisms in respiratory toxicology. Boca Raton: CRC Press; 1982;p. 189
  52. Rustow B, Haupt R, Stevens PA, Kunze D. Type II pneumocytes secret vitamin E together with surfactant lipids. Am J Physiol. 1993;256:L133
  53. Bjorneboe A, Bjorneboe GEA, Drevon CA. Absorption, transport, and distribution of vitamin E. J Nutr. 1990;120:232
  54. Kayden HJ, Traber MG. Absorption, lipoprotein transport, and regulation of plasma concentration of vitamin E in humans. J Lipid Res. 1993;34:343
  55. Parks EJ, Dare D, Frazier KB, et al.  Dependence of plasma α-tocopherol flux on very low-density triglyceride clearance in humans. Free Radic Biol Med. 2000;29:1151
  56. Shaw H-M, Huang C-J. Secretion of α-tocopherol in VLDL is decreased by dietary protein insufficiency in young growing rats. J Nutr. 2000;130:3050
  57. Kolleck I, Schlame M, Fechner H, et al.  HDL is the major source of vitamin E for type II pneumocytes. Free Radic Biol Med. 1999;27:882
  58. Maxwell SR. Prospects for use of antioxidant therapies. Drugs. 1995;49:345
  59. Lee C-Y  J , Wan J  M-F . Vitamin E supplementation improved cell-mediated immunity and oxidative stress of Asian men and women. J Nutr. 2000;130:2932

PII: S0899-9007(01)00646-3

Nutrition
Volume 17, Issue 10 , Pages 828-834 , October 2001