Nutrition
Volume 17, Issue 10 , Pages 835-838 , October 2001

Antioxidants: an integrative approach

  • Paul A. Lachance, PhD

      Affiliations

    • Nutraceuticals Institute, Department of Food Science, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA
    • Corresponding Author InformationCorrespondence to: Paul A. Lachance, PhD, The Nutraceuticals Institute, Department of Food Science, Rutgers, The State University of New Jersey, 65 Dudley Road, New Brunswick, NJ 08901-8520, USA
    • ,
  • Zeina Nakat, BS

      Affiliations

    • Nutraceuticals Institute, Department of Food Science, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA
    • ,
  • Woo-Sik Jeong, MS

      Affiliations

    • Nutraceuticals Institute, Department of Food Science, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA

,Accepted 1 June 2001.

References 

  1. In:  Machlin LJ editors. Vitamin E (a comprehensive treatise). New York: Marcel Dekker; 1980;
  2. In:  Diplock AT,  Machlin LJ,  Packer L,  Pryor WA editor. Vitamin E (biochemistry and health implications). New York: New York Academy of Sciences; 1989;
  3. Machlin LJ, ed. Handbook of vitamins, 1st/2nd eds. New York: Marcel Dekker, 1984/1991
  4. Halliwell B. Oxidants and human disease (some new concepts). FASEB J. 1987;1:358
  5. Machlin LJ, Bendich A. Free radical tissue damage (protective role of antioxidant nutrients). FASEB J. 1987;1:441
  6. Kong Q, Beel JA, Lillehei KO. A threshold concept for cancer therapy. Med Hypotheses. 2000;55:29
  7. Fries JF, Koop CE, Beadle CE, et al.  Reducing health care costs by reducing the need and demand for medical services. N Engl J Med. 1993;329:321
  8. Guhr G, Lachance PA. Role of phytochemicals in chronic disease prevention. In:  Lachance LA editors. Nutraceuticals (designer foods III: garlic, soy and licorice). Trumbull: Food and Nutrition Press; 1997;p. 311
  9. Esterbauer H, Ramos P. Chemistry and pathophysiology of oxidation of LDL. Rev Physiol Biochem Pharmacol. 1996;127:31
  10. Institute of Medicine . Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington, DC: National Academy Press; 2000;
  11. Gopalakrishna R, Jaken S. Protein kinase C signaling and oxidative stress. Free Radic Biol Med. 2000;28:1349
  12. Jaeschke H. Reactive oxygen and mechanisms of inflammatory liver injury. J Gastroenterol Hepatol. 2000;15:718
  13. Rusyn I, Rose ML, Bojes HK, Thurman RG. Novel role of oxidants in the molecular mechanism of action of peroxisome proliferators. Antioxid Redox Signal. 2000;2:607
  14. Steiling H, Munz B, Werner S, Brauchle M. Different types of ROS-scavenging enzymes are expressed during cutaneous wound repair. Exp Cell Res. 1999;247:484
  15. Herrera B, Alvarez AM, Sanchez A, et al.  Reactive oxygen species (ROS) mediate the mitochondrial-dependent apoptosis induced by transforming growth factor (beta) in fetal hepatocytes. FASEB J. 2001;15:741
  16. Davis W, Ronai Z, Tew KD. Cellular thiols and reactive oxygen species in drug-induced apoptosis. J Pharmacol Exp Ther. 2001;296:1
  17. Allen RG, Tresini M. Oxidative stress and gene regulation. Free Radic Biol Med. 2000;28:463
  18. Eiserich JP, van der Vliet A, Handelman GJ, Halliwell B, Cross CE. Dietary antioxidants and cigarette smoke-induced biomolecular damage (a complex interaction). Am J Clin Nutr. 1995;62(suppl)::1490S
  19. Elsayed NM, Bendich A. Dietary antioxidants (potential effects on oxidative products in cigarette smoke). Nutr Res. 2000;21:551
  20. Valkonen MM, Kuusi T. Vitamin C prevents the acute atherogenic effects of passive smoking. Free Rad Biol Med. 2000;28:428
  21. Mustafa MG. Biochemical basis of ozone toxicity. Free Radic Biol Med. 1990;9:245
  22. Doelman CJ, Leurs R, Oosterom WC, Bast A. Mineral dust exposure and free radical-mediated lung damage. Exp Lung Res. 1990;16:41
  23. Twaroski TP, O’Brien ML, Larmonier N, Glauert HP, Robertson LW. Polychlorinated biphenyl-induced effects on metabolic enzymes, AP-1 binding, vitamin E, and oxidative stress in the rat liver. Toxicol Appl Pharm. 2001;171:85
  24. Arroyo PL, Hatch-Pigott V, Mower HF, Cooney RV. Mutagenicity of nitric oxide and its inhibition by antioxidants. Mutat Res. 1992;281:193
  25. Tu B, Wallin A, Moldeus P, Cotgreave I. The cytoprotective roles of ascorbate and glutathione against nitrogen dioxide toxicity in human endothelial cells. Toxicology. 1995;98:125
  26. Bohm F, Edge R, McGarvey DJ, Truscott TG. Beta Carotene with vitamins E and C offers synergistic cell protection against NOx. FEBS Lett. 1998;436:387
  27. ATBC Cancer Prevention Study Group . The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancer in male smokers. N Engl J Med. 1994;330:1029
  28. Omenn GS, Goodman GE, Thomquist MD, et al.  Risk factors for lung cancer and for intervention effects in CARET, the beta carotene and retinol efficacy trial. J Natl Cancer Inst. 1996;88:1550
  29. Omenn GS, Goodman GE, Thomquist MD, et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996;334:1150
  30. Hennekens CH, Buring JE, Manson JE, et al.  Lack of effect of long-term supplementation with beta-carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med. 1996;334:1145
  31. Mason RP, Fischer V. Free radicals of acetaminophen (their subsequent reactions and toxicological significance). FASEB J. 1986;45:2493
  32. Viola G, Miolo G, Vedaldi D, Dall’Acqua F. In vitro studies of the phototoxic potential of the antidepressant drugs amitriptyline and imipramine. Farmaco. 2000;55:211
  33. Pagano G, de Biase A, Deeva IB, et al.  The role of oxidative stress in developmental and reproductive toxicity of tamoxifen. Life Sci. 2001;68:1735
  34. Longoni B, Boschi E, Demontis GC, et al.  Apoptosis and adaptive responses to oxidative stress in human endothelial cells exposed to cyclopsprin A correlate with BCL-2 expressions levels. FASEB J. 2001;15:731
  35. Gurbay A, Gonthier B, Daveloose D. Microsomal metabolism of ciprofloxacin generates free radicals. Free Radic Biol Med. 2001;30:1118
  36. Inserra PF, Ardestani SK, Watson RR. Antioxidants and immune function. In:  Garewal HS editors. Antioxidants and disease prevention. Boca Raton: CRC Press; 1997;p. 19
  37. Jacques PF. Nutritional antioxidants and prevention of age-related eye disease. In:  Garewal HS editors. Antioxidants and disease prevention. Boca Raton: CRC Press; 1997;p. 149
  38. Varma SD, Richards RD. Ascorbic acid and the eye lens. Ophthal Res. 1988;20:164
  39. Hu FB, Hankinson SE, Stampfer MJ, et al.  Prospective study of cataract extraction and risk of coronary artery disease in women. Am J Epidmiol. 2001;153:875
  40. Singh VN. A current perspective on nutrition and exercise. J Nutr. 1992;122(suppl)::760
  41. Dandekar T. Free radicals and memory loss. Redox Rep. 1997;3:71
  42. Bickford PC, Gould T, Briederick L, et al.  Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats. Brain Res. 2000;866:211
  43. Lachance PA. Future vitamin and antioxidant RDAs for health promotion. Prev Med. 1996;25:46
  44. Van der Vliet A, Cross CE. Oxidants, nitrosants and the lung. Am J Med. 2000;109:398
  45. In:  Chiueh CC editors. Reactive oxygen species (from radiation to molecular biology). New York: New York Adacamy of Sciences; 2000;
  46. Kant AK, Schatzkin A, Harris TB, Ziegler RG, Block G. Dietary diversity and subsequent mortality in the First National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. Am J Clinic Nutr. 1993;57:434

PII: S0899-9007(01)00636-0

Nutrition
Volume 17, Issue 10 , Pages 835-838 , October 2001

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