Nutrition
Volume 17, Issue 4 , Pages 354-355 , April 2001

Can posttraumatic insulin resistance be attenuated by prior glucose loading?

  • C.R Byrne, PhD

      Affiliations

    • MRC Trauma Group and Department of Surgery University of Manchester Hope Hospital, Salford, UK
    • ,
  • G.L Carlson, BSc, MD, FRCS

      Affiliations

    • MRC Trauma Group and Department of Surgery University of Manchester Hope Hospital, Salford, UK
    • Corresponding Author InformationCorrespondence to: Clare R. Byrne, PhD, MRC Trauma Group,University of Manchester, Hope Hospital, Salford M6 8HD, UK.

References 

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  2. Howard JM. Studies of the absorption and metabolism of glucose following injury. Ann Surg. 1955;141:321
  3. Thorell A, Nygren J, Ljungqvist O. Insulin resistance (a marker of surgical stress). Curr Opin Nutr Metab Care. 1999;2:69
  4. DeFronzo RA, Gunnarsson R, Bjorkman O, et al.  Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest. 1985;76:149
  5. Saeed M, Carlson GL, Little RA, Irving MH. Selective impairment of glucose storage in human sepsis. Br J Surg. 1999;86:813
  6. Michie HR. Metabolism of sepsis and multiple organ failure. World J Surg. 1996;20:460
  7. Sakurai Y, Aarsland A, Herndon DN, et al.  Stimulation of muscle protein synthesis by long-term insulin infusion in severely burned patients. Ann Surg. 1995;222:283
  8. Woolfson AMJ, Heatley RV, Allison SP. Insulin to inhibit protein catabolism after injury. N Engl J Med. 1979;300:14
  9. Brandi LS, Frediani M, Oleggini M, et al.  Insulin resistance after surgery (normalisation by insulin treatment). Clin Sci. 1990;79:443
  10. Pierre EJ, Barrow RE, Hawkins HK, et al.  Effects of insulin on wound healing. J Trauma. 1998;44:342
  11. Thorell A, Efendic S, Gutniak M, Haggmark T, Ljungqvist O. Insulin resistance after abdominal surgery. Br J Surg. 1994;81:59
  12. Uchida I, Asoh T, Shirasaka C, Tsuji H. Effect of epidural analgesia on postoperative insulin resistance as evaluated by insulin clamp technique. Br J Surg. 1988;75:557
  13. Ljungqvist O, Thorell A, Gutniak M, Haggmark T, Efendic S. Glucose infusion instead of preoperative fasting reduces postoperative insulin resistance. J Am Coll Surg. 1994;178:329
  14. Nygren J, Soop M, Thorell A, et al.  Preoperative oral carbohydrate administration reduces postoperative insulin resistance. Clin Nutr. 1998;17:65
  15. Nygren J, Soop M, Thorell A, Sree-Nair K, Ljungqvist O. Preoperative oral carbohydrates and postoperative insulin resistance. Clin Nutr. 1999;18:117
  16. Strömmer L, Isaksson B, Wickbom B, et al.  Effect of carbohydrate feeding on insulin action in skeletal muscle after surgical trauma in the rat. Nutrition. 2001;17:331

PII: S0899-9007(00)00591-8

Nutrition
Volume 17, Issue 4 , Pages 354-355 , April 2001

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