Nutrition
Volume 17, Issue 4 , Pages 332-336 , April 2001

Effect of carbohydrate feeding on insulin action in skeletal muscle after surgical trauma in the rat

  • Lisa Strömmer, MD

      Affiliations

    • Arvid Wretlinds Laboratory for Metabolic and Nutritional Research, Department of Surgery, Karolinska Institute at Huddinge University Hospital, Stockholm, Sweden
    • Corresponding Author InformationCorrespondence to: Lisa Strömmer, MD, Department of Surgery, Huddinge University Hospital, 141 86 Stockholm, Sweden.
    • ,
  • Bengt Isaksson, MD

      Affiliations

    • Arvid Wretlinds Laboratory for Metabolic and Nutritional Research, Department of Surgery, Karolinska Institute at Huddinge University Hospital, Stockholm, Sweden
    • ,
  • Malin Wickbom, MD

      Affiliations

    • Arvid Wretlinds Laboratory for Metabolic and Nutritional Research, Department of Surgery, Karolinska Institute at Huddinge University Hospital, Stockholm, Sweden
    • ,
  • Urban Arnelo, MD, PhD

      Affiliations

    • Arvid Wretlinds Laboratory for Metabolic and Nutritional Research, Department of Surgery, Karolinska Institute at Huddinge University Hospital, Stockholm, Sweden
    • ,
  • Claes-Göran Östenson, MD, PhD

      Affiliations

    • Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden
    • ,
  • Margery Herrington, PhD

      Affiliations

    • Arvid Wretlinds Laboratory for Metabolic and Nutritional Research, Department of Surgery, Karolinska Institute at Huddinge University Hospital, Stockholm, Sweden
    • Department of Biology, Adams State College, Alamosa, Colorado, USA
    • ,
  • Johan Permert, MD, PhD

      Affiliations

    • Arvid Wretlinds Laboratory for Metabolic and Nutritional Research, Department of Surgery, Karolinska Institute at Huddinge University Hospital, Stockholm, Sweden

,Accepted 25 October 2000.

References 

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  3. Ljungqvist O, Thorell A, Gutniak M, et al.  Glucose infusion instead of preoperative fasting reduces postoperative insulin resistance. J Am Coll Surg. 1994;178:329
  4. Nygren J, Thorell A, Efendic S, et al.  Site of insulin resistance after surgery (the contribution of hypocaloric nutrition and bed rest). Clin Sci (Colch). 1997;93:137
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  6. Nygren J, Soop M, Thorell A, et al.  Preoperative oral carbohydrate administration reduces postoperative insulin resistance. Clin Nutr. 1998;17:65
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  9. Song XM, Kawano Y, Krook A, et al.  Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats. Diabetes. 1999;48:664
  10. Olefsky JM, Kolterman OG, Scarlett JA. Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus. Am J Physiol. 1982;243:E15
  11. Strommer L, Permert J, Arnelo U, et al.  Skeletal muscle insulin resistance after trauma (insulin signaling and glucose transport). Am J Physiol. 1998;275:E351
  12. Strommer L, Isaksson B, Arnelo U, et al.  Preoperative feeding does not reverse postoperative insulin resistance in skeletal muscle in the rat. Metabolism. 2000;49:486
  13. Tsukamoto H, Reidelberger RD, French SW, et al.  Long-term cannulation model for blood sampling and intragastric infusion in the rat. Am J Physiol. 1984;247:R595
  14. Wallberg-Henriksson H, Zetan N, Henriksson J. Reversibility of decreased insulin-stimulated glucose transport capacity in diabetic muscle with in vitro incubation (insulin is not required). J Biol Chem. 1987;262:7665
  15. Megeney LA, Neufer PD, Dohm GL, et al.  Effects of muscle activity and fiber composition on glucose transport and GLUT-4. Am J Physiol. 1993;264:E583
  16. Nygren J, Thorell A, Jacobsson H, et al.  Preoperative gastric emptying (effects of anxiety and oral carbohydrate administration). Ann Surg. 1995;222:728
  17. Nygren JO, Thorell A, Soop M, et al.  Perioperative insulin and glucose infusion maintains normal insulin sensitivity after surgery. Am J Physiol. 1998;275:E140
  18. Ren JM, Marshall BA, Gulve EA, et al.  Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle. J Biol Chem. 1993;268:16113
  19. Lombardi AM, Moller D, Loizeau M, et al.  Phenotype of transgenic mice overexpressing GLUT4 and hexokinase II in muscle. FASEB J. 1997;11:1137
  20. Chiasson JL, Shikama H, Chu DT, et al.  Inhibitory effect of epinephrine on insulin-stimulated glucose uptake by rat skeletal muscle. J Clin Invest. 1981;68:706
  21. Alberti KG, Batstone GF, Foster KJ, et al.  Relative role of various hormones in mediating the metabolic response to injury. JPEN. 1980;4:141
  22. Rutberg H, Hakanson E, Anderberg B, et al.  Effects of the extradural administration of morphine, or bupivacaine, on the endocrine response to upper abdominal surgery. Br J Anaesth. 1984;56:233
  23. Thorell A, Alston-Smith J, Ljungqvist O. The effect of preoperative carbohydrate loading on hormonal changes, hepatic glycogen, and glucoregulatory enzymes during abdominal surgery. Nutrition. 1996;12:690
  24. Stenberg A, Gustavsson S, Lundqvist G, et al.  Effect of surgical trauma on plasma insulin and somatostatin in response to glucose. Acta Chir Scand. 1984;150:119
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☆ This study was supported by grants 00034 and K99-72X-1265-02B from the Swedish Medical Research Council, the Swedish Diabetes Association, and Förenade Liv Mutual Group Life Insurance Company, Stockholm, Sweden.

PII: S0899-9007(00)00587-6

Nutrition
Volume 17, Issue 4 , Pages 332-336 , April 2001

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