Nutrition
Volume 17, Issue 4 , Pages 337-346 , April 2001

Nutritional factors in the pathobiology of human essential hypertension

  • Undurti N. Das, MD, FAMS

      Affiliations

    • From EFA Sciences LLC, Norwood, Massachusetts, USA
    • Corresponding Author InformationCorrespondence to: U. N. Das, MD, FAMS, EFA Sciences LLC, 1420 Providence Highway, Suite 266, Norwood, MA 02062, USA.

,Accepted 27 October 2000.

References 

  1. Law M. Salt, blood pressure and cardiovascular diseases. J Cardiovasc Risk. 2000;7:5
  2. Nakagawa H, Morikawa Y, Okayama A, et al.  Trends in blood pressure and urinary sodium and potassium excretion in Japan (reinvestigation in the 8th year after the Intersalt study). J Hum Hypertens. 1999;13:735
  3. Cook NR, Kumanyika SK, Cutler JA. Effect of change in sodium excretion on change in blood pressure corrected for measurement error (the trials of hypertension prevention, phase I). Am J Epidemiol. 1998;148:431
  4. Stamler J. The Intersalt study (background, methods, findings, and implications). Am J Clin Nutr. 1997;65:626S
  5. Elliott P, Stamler J, Nichols R, et al.  Intersalt revisited: further analyses of 24 hour sodium excretion and blood pressure within and across populations. Intersalt Cooperative Research Group. BMJ. 1996;312:1249
  6. Stamler J, Elliott P, Kesteloot H, et al.  Inverse relation of dietary protein markers with blood pressure findings for 10,020 men and women in the Intersalt study. Intersalt Cooperative Research Group. International study of salt and blood pressure. Circulation. 1996;94:1629
  7. Law MR, Frost CD, Wald NJ. By how much does dietary salt reduction lower blood pressure? I—Analysis of observational data among populations. BMJ. 1991;302:811
  8. Frost CD, Law MR, Wald NJ. By how much does dietary salt reduction lower blood pressure? II—Analysis of observational data within populations. BMJ. 1991;302:815
  9. Law MR, Frost CD, Wald NJ. By how much does dietary salt reduction lower blood pressure? III—Analysis of data from trials of salt reduction. BMJ. 1991;302:819
  10. Law MR, Frost CD, Wald NJ. Dietary salt and blood pressure. J Hypertens 1991;9(suppl):S37
  11. Graudal NA, Galloe AM, Garred P. Effects of sodium restriction on blood pressure, rennin, aldosterone, catecholamines, cholesterols, and triglyceride (a meta-analysis). JAMA. 1998;279:1383
  12. Swales JD. Studies of salt intake in hypetension. What can epidemiology teach us? Am J Hypertens 1990;3(8, pt 1):645
  13. Swales JD. Salt and blood pressure. Blood Press. 1992;1:201
  14. Swales JD. Salt and blood pressure revisited. J Hum Hypertens. 1995;9:517
  15. Swales J. Population advice on salt restriction: the social issues. Am J Hypertens 2000;13 (1, pt 1):2
  16. Alderman MH, Cohen H, Madhavan S. Dietary sodium intake and mortality (the National Health and Nutrition Examination Survey). Lancet. 1998;351:781
  17. Taubes G. The (political) science of salt. Science. 1998;281:898
  18. Whelton PK, He J, Cutler JA, et al.  Effects of oral potassium on blood pressure (meta-analysis of randomized controlled clinical trials). JAMA. 1997;277:1624
  19. Appel LJ, Moore TJ, Obarzanek E, et al.  A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med. 1997;336:1117
  20. McCarron DA, Morris CD, Henry HJ, Stanton JL. Blood pressure and nutrient intake in the United States. Science. 1984;224:1392
  21. McCarron DA. Diet and blood pressure—the paradigm shift. Science. 1998;281:933
  22. Das UN. Minerals, trace elements, and vitamins interact with essential fatty acids and prostaglandins to prevent hypertension, thrombosis, hypercholesterolaemia and atherosclerosis and their attendant complications. IRCS Med Sci. 1985;13:684
  23. Tannen RL. Effects of potassium on blood pressure control. Ann Intern Med. 1983;98:773
  24. Katz A, Rosenthal T, Maoz C, et al.  Effect of a mineral salt diet on 24-hour blood pressure monitoring in elderly hypertensive patients. J Hum Hypertens. 1999;13:777
  25. Nakagawa H, Morikawa Y, Okayama A, et al.  Trends in blood plasma and urinary sodium and potassium excretion in Japan (reinvestigation in the 8th year after the Intersalt study). J Hum Hypertens. 1999;13:735
  26. Department of Health and Human Services. DHSS Publications (PH 5). London, 1983:83
  27. Chandalia M, Abate N, Garg A, Stray-Gunderson J, Grundy SM. Relationship between generalized and upper body obesity to insulin resistance in Asian Indian men. J Clin Endocrinol Metab. 1999;84:2329
  28. Banerji MA, Faridi N, Atluri R, Chaiken RL, Lebovito HE. Body composition, visceral fat, leptin and insulin resistance in Asian Indian men. J Clin Endocrinol Metab. 1999;84:137
  29. Landsberg L. Role of the sympathetic adrenal system in the pathogenesis of the insulin resistance syndrome. Ann NY Acad Sci. 1999;892:84
  30. Young JB, Landsberg L. Suppression of sympathetic nervous system during fasting. Science. 1977;196:1473
  31. Young JB, Rosa RM, Landsberg L. Dissociation of sympathetic nervous system and adrenal medullary responses. Am J Physiol. 1984;247:E35
  32. Young JB, Landsberg L. Stimulation of the sympathetic nervous system during sucrose feeding. Nature. 1977;269:615
  33. Walgren MC, Young JB, Kaufman LN, Landsberg L. The effects of various carbohydrates on sympathetic activity in heart and interscapular brown adipose tissue (IBAT) of the rat. Metabolism. 1987;36:585
  34. Schwartz JH, Young JB, Landsberg L. Effect of dietary fat on sympathetic nervous system activity in the rat. J Clin Invest. 1983;72:361
  35. Das UN. GLUT-4, tumor necrosis factor, essential fatty acids and daf—genes and their role in insulin resistance and non-insulin dependent diabetes mellitus. Prostaglandins Leukot Essent Fatty Acids. 1999;60:13
  36. Uysal KT, Wesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature. 1997;389:610
  37. Hughes K, Aw TC, Kuperan P, Choo M. Central obesity, insulin resistance, syndrome X, lipoprotein(a) and cardiovascular risk in Indians, Malayas and Chinese in Singapore. J Epidemiol Community Health. 1997;51:394
  38. Das UN. Possible beneficial action(s) of glucose-insulin-potassium regimen in acute myocardial infarction and inflammatory conditions (a hypothesis). Diabetologia. 2000;43:1081
  39. Waeber G, Calandra T, Bonny C, Bucala R. A role for the endocrine and pro-inflammatory mediator MIF in the control of insulin secretion during stress. Diabetes Metab Res Rev. 1999;15:47
  40. Borovikova LV, Ivanova S, Zhang M, et al.  Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature. 2000;405:458
  41. Milled GD, DiRienzo DD, Reusser ME, McCarron DA. Benefits of dairy product consumption on blood pressure in humans (a summary of the biomedical literature). J Am Coll Nutr. 2000;19:147S
  42. Kolata G. Does a lack of calcium cause hypertension?. Science. 1984;225:705
  43. Altura BM, Altura BT, Carella A. Magnesium deficiency-induced spasms of umbilical vessels (relation to preeclampsia, hypertension, growth retardation). Science. 1983;221:376
  44. Saris NE, Mervaala E, Karppanen H, Khawaja JA, Lewenstava A. Magnesium (an update on physiological, clinical and analytical aspects). Clin Chim Acta. 2000;294:1
  45. Siegel G, Walter A, Gustavsson H, Lindman B. Magnesium and membrane function in vascular smooth muscle. Artery. 1981;9:232
  46. Kisters K, Krefting ER, Barenbrock M, Spieker C, Rahn KH. Na+ and Mg+ contents in smooth muscle cells in spontaneously hypertensive rats. Am J Hypertens. 1999;12:648
  47. Sanders GM, Sim KM. Is it feasible to use magnesium sulfate as a hypotensive agent in oral and maxillofacial surgery?. Ann Acad Med Singapore. 1998;27:780
  48. Witlin AG, Sibai BM. Magnesium sulfate therapy in preeclampsia and eclampsia. Obstet Gynecol. 1998;92:883
  49. Sudhakar K, Sujatha M, Rao VB, Jyothy A, Reddy PP. Serum and erythrocyte magnesium levels in hypertension and their first degree relatives. J Indian Med Assoc. 1999;97:211
  50. Corica F, Corsonello A, Buemi M, et al.  Platelet magnesium depletion in normotensive and hypertensive obese subjects (the role of salt-regulating hormones and catecholamines). Magnes Res. 1999;12:287
  51. Das UN. Nutrients, essential fatty acids and prostaglandins interact to augment immune responses and prevent genetic damage and cancer. Nutrition. 1989;5:106
  52. Das UN. Essential fatty acids (biology and their clinical implications). Asia Pacific J Pharmacol. 1991;6:317
  53. Das UN, Horrobin DF, Begin ME, et al.  Clinical significance of essential fatty acids. Nutrition. 1988;4:337
  54. Duffy SJ, Gokce N, Holbrook M, et al.  Treatment of hypertension with ascorbic acid. Lancet. 1999;354:2048
  55. Das UN. Hypertension and ascorbic acid. Lancet. 2000;355:1273
  56. Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation. 1998;97:2222
  57. Kruse HJ, Grunberg B, Siess W, Weber PC. Formation of biologically active autacoids is regulated by calcium influx in endothelial cells. Arterioscler Thromb. 1994;14:1821
  58. Lahera V, Ruilope LM, Romero JC. A single mechanism to explain the effect of calcium on renal function. Am J Hypertens. 1991;4:473S
  59. Miyoshi A, Suzuki H, Fujiwara M, Masai M, Iwasaki T. Impairment of endothelial function in salt-sensitive hypertnesion in humans. Am J Hypertens 1997;10(10, pt 1):1083
  60. Fujiwara N, Osanai T, Kamada T, et al.  Study of the relationship between plasma nitrite and nitrate level and salt sensitivity in human hypertension (modulation of nitric oxide synthesis by salt intake). Circulation. 2000;101:856
  61. Taddei S, Mattei P, Virdis A, et al.  Effect of potassium on vasodilation to acetylcholine in essential hypertension. Hypertension. 1994;23:485
  62. Pearson PJ, Evora PR, Seccombe JF, Schaff HV. Hypomagnesemia inhibits nitric oxide release from coronary endothelium (protective role of magnesium infusion after cardiac operations). Ann Thorac Surg. 1998;65:967
  63. Das UN. Essential fatty acids in health and disease. J Assoc Phys India. 1999;47:906
  64. Iacono JM, Judd JT, Marshall MW, et al.  The role of dietary essential fatty acids and prostaglandins in reducing blood pressure. Prog Lipid Res. 1981;20:349
  65. Tobian L, Ganguli M, Johnson MA, Iwai J. Influence of renal prostaglandins and dietary linoleate on hypertension in Dahl rats. Hypertension 1982;4(suppl): 149
  66. Hoffman P, Forster W, Markov Ch M. Attenuation of blood pressure increase in spontaneously hypertensive rats by diets enriched with polyunsaturated fatty acids. Prostaglandins Leukot Med. 1982;8:151
  67. Grimsgaard S, Bonaa KH, Jacobson BK, Bjerve KS. Plasma saturated and linoleic fatty acids are independently associated with blood pressure. Hypertension. 1999;34:478
  68. Wilde DW, Massey KD, Walker GK, Vollmer A, Grekin RJ. High-fat diet elevates blood pressure and cerebrovascular muscle Ca(2+) current. Hypertension. 2000;35:832
  69. Hassall CH, Kirtland SJ. Dihomo-gamma-linolenic acid reverses hypertension induced in rats by diets rich in saturated fat. Lipids. 1984;19:699
  70. Rupp H, Turcani M, Ohkubo T, Maisch B, Brilla CG. Dietary linolenic acid-mediated increase in vascular prostacyclin formation. Mol Cell Biochem. 1996;162:59
  71. Mills DE, Ward R. Attenuation of psychosocial stress-induced hypertension by gamma-linolenic acid (GLA) administration in rats. Proc Soc Exp Biol Med. 1984;176:32
  72. Engler MM, Schambelan M, Engler MB, Ball DL, Goodfriend TL. Effects of gamma-linolenic acid on blood pressure and adrenal angiotensin receptors in hypertensive rats. Proc Soc Exp Biol Med. 1998;218:234
  73. Mamalakis G, Kafatos A, Tornaritis M, Alevizos B. Anxiety and adipose essential fatty acid precursors for prostaglandin E1 and E2. J Am Coll Nutr. 1998;17:239
  74. Williams LL, Kiecolt-Glaser JK, Horrocks LA, Hillhouse JT, Glaser R. Quantitative association between altered plasma esterified omega-6-fatty acid proportions and psychological stress. Prostaglandins Leukot Essent Fatty Acids. 1992;47:165
  75. Yao JK, Leonard S, Reddy RD. Membrane phospholipid abnormalities in postmortem brains from schizophrenic patients. Schizophr Res. 2000;42:7
  76. Woodcock BE, Smith E, Lambert WH, et al.  Beneficial effect of fish oil on blood viscosity in peripheral vascular disease. BMJ. 1984;288:592
  77. Engler MB, Ma YH, Engler MM. Calcium-mediated mechanisms of eicosapentaenoic acid-induced relaxation in hypertensive rat aorta. Am J Hypertens. 1999;12:1225
  78. Engler MM, Engler MB, Goodfriend TL, et al.  Docosahexaenoic acid is an anti-hypertensive nutrient that affects aldotserone production in SHR. Proc Soc Exp Biol Med. 1999;221:32
  79. Prisco D, Paniccia R, Bandinelli B, et al.  Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. Thromb Res. 1998;91:105
  80. Rousseau D, Moreau D, Raederstorff D, et al.  Is a dietary n-3 fatty acid supplement able to influence the cardiac effect of the psychological stress?. Mol Cell Biochem. 1998;178:353
  81. Mori TA, Bao DQ, Burke V, Puddey IB, Beilin LJ. Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. Hypertension. 1999;34:253
  82. Das UN. Biological significance of arachidonic acid. Med Sci Res. 1987;24:1485
  83. Moncada S. Nitric oxide in the vasculature (physiology and pathophysiology). Ann NY Acad Sci. 1997;811:60
  84. Kumar KV, Das UN. Are free radicals involved in the pathophysiology of human essential hypertension?. Free Rad Res Commun. 1993;19:59
  85. Uwabo J, Soma M, Nakayama T, Kanmatsuse K. Association of a variable number of tandem repeats in the endothelial constitutive nitric oxide synthase gene with essential hypertension in Japanese. Am J Hypertens. 1998;11:125
  86. Vapaatalo H, Mervaala E, Nurminen ML. Role of endothelium and nitric oxide in experimental hypertension. Physiol Res. 2000;49:1
  87. Rees D, Ben-Ishay D, Moncada S. Nitric oxide and the regulation of blood pressure in the hypertension-prone and hypertension-resistant Sabra rat. Hypertension. 1996;28:367
  88. Bode-Boger SM, Boger RH, Kielstein JT, et al.  Role of endogenous nitric oxide in circadian blood pressure regulation in healthy humans and in patients with hypertension or atherosclerosis. J Invest Med. 2000;48:125
  89. Cachofeiro V, Sakakibara T, Nasiletti A. Kinins, nitric oxide and the hypertensive effect of captopril and ramipril in hypertension. Hypertension. 1992;19:138
  90. Lin ZW, Wohlfart P, Scholkens BA, Malinski T, Wiemer G. Interactions among ACE, kinins and NO. Cardiovasc Res. 1999;43:549
  91. McIntyre M, Bohr DF, Dominiczak AF. Endothelial function in hypertension (the role of superoxide anion). Hypertension. 1999;34:539
  92. Munzel T, Hink U, Heitzer T, Meinertz T. Role of NADPH/NADH oxidase in the modulation of vascular tone. Ann NY Acad Sci. 1999;874:386
  93. Weimer G, Linz W, Hatrik S, Scholkens BA, Malinski T. Angiotensin converting enzyme inhibition alters nitric oxide and superoxide release in normotensive and hypertensive rats. Hypertension. 1997;30:1183
  94. Kumar KV, Das UN. Effect of cis-unsaturated fatty acids prostaglandins and free radicals on angiotensin converting enzyme activity in vitro. Proc Soc Exp Biol Med. 1997;214:374
  95. Suryaprabha P, Das UN, Koratkar R, Sagar PS, Ramesh G. Free radical generation lipid peroxidation and essential fatty acids in uncontrolled essential hypertension. Prostaglandins Leukot Essential Fatty Acids. 1990;41:27
  96. Das UN. Beneficial action(s) of eicosapentaenoic acid/docosahexaenoic acid and nitric oxide in systemic lupus erythematosus. Med Sci Res. 1995;23:723
  97. Haglund O, Mental JL, Saldeen T. Effects of fish oil on some parameters of fibrinolysis and lipoprotein(a) in healthy subjects. Am J Cardiol. 1994;74:189
  98. Bang HO, Dyerberg J, Nielsen AB. Plasma lipid and lipoprotein pattern in Greenlandic west coast Eskimos. Lancet. 1971;i:1143
  99. Pauletto P, Puato M, Carold MG, et al.  Blood pressure and atherogenic lipoprotein profiles of fish-diet and vegetarian villagers in Tanzania (the Lugalewa study). Lancet. 1996;348:784
  100. Nelson GJ, Schmidt PC, Bartolini G, et al.  The effect of dietary arachidonic acid on plasma lipoprotein distributions, apoproteins, blood lipid levels, and tissue fatty acid composition in humans. Lipids. 1997;32:427
  101. Nelson GJ, Schmidt PC, Bartolini G, Kelley DS, Kyle D. The effect of dietary arachidonic acid on platelet function, platelet fatty acid composition and blood coagulation in humans. Lipids. 1997;32:421
  102. Das UN. Essential fatty acids metabolism in patients with essential hypertension, diabetes mellitus and coronary heart disease. Prostaglandins Leukot Essent Fatty Acids. 1995;52:387
  103. GISSI Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet. 1999;354:447
  104. Connor SL, Connor WE. Are fish oils beneficial in the prevention and treatment of coronary artery disease?. Am J Clin Nutr. 1997;66:1020S
  105. Kagawa Y, Nishizawa M, Suzuki M, et al.  Eicosapentaenoic acids of serum lipids of Japanese Islanders with low incidence of cardiovascular diseases. J Nutr Sci Vitaminol. 1982;28:441
  106. Leaf A, Weber PC. Cardiovascular effects of n-3 fatty acids. N Engl J Med. 1988;318:549
  107. Padhani A, Dandona P. Diabetes and coronary heart disease in north London Asians. Lancet. 1986;i:213
  108. Bhopal R, Unwin N, White M, et al.  Heterogeneity of coronary heart disease risk factors in Indian, Pakistani, Bangladeshi, and European origin populations (cross sectional study). BMJ. 1999;319:215
  109. Juan H, Sametz W. Dihomo-gamma-linolenic acid increases the metabolism of eicosapentaenoic acid in perfused vascular tissue. Prostaglandinn Leukot Med. 1985;19:79
  110. Bordet JC, Guichardant M, Lagarde M. Hydroperoxides produced by n-6 lipoxygenation of arachidonic and linoleic acids potentiate synthesis of prostacyclin related compounds. Biochim Biophys Acta. 1988;958:460
  111. Bordet JC, Guichardant M, Lagarde M. Arachidonic acid strongly stimulates prostaglandin I3 (PGI3) production from eicosapentaenoic acid in human endothelial cells. Biochem Biophys Res Commun. 1986;135:403
  112. Salonen JT, Alfthan G, Huttunen JK, Pikkarainen J, Puska P. Association between cardiovascular death and myocardial infarction and serum selenium in a matched-pair longitudinal study. Lancet. 1982;ii:175
  113. Salonen JT, Salonen R, Penttila I, et al.  Serum fatty acids, apolipoproteins, selenium and vitamin antioxidants and the risk of death from coronary artery disease. Am J Cardiol. 1985;56:226
  114. Meydani M. Modulation of the platelet thromxoxane A2 and aortic prostacyclin synthesis by dietary selenium and vitamin E. Biol Trace Elem Res. 1992;33:79
  115. McVeigh GE, Brennan GM, Johnson GD, et al.  Dietary fish oil augments nitric oxide production or release in patients with type 2 (non-insulin dependent) diabetes mellitus. Diabetologia. 1993;36:33
  116. Mohan IK, Das UN. Prevention of chemically induced diabetes mellitus in experimental animals by polyunsaturated fatty acids. Nutrition. 2001;17:126
  117. Mohan IK, Das UN. Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus. Prostaglandins Leukot Essent Fatty Acids. 2000;62:35
  118. Reaven G. Banting lecture 1988 (role of insulin resistance in human disease). Diabetes. 1988;37:1595
  119. Das UN. Insulin resistance and hyperinsulinaemia (are they secondary to an alteration in the metabolism of essential fatty acids?). Med Sci Res. 1994;22:243
  120. Balarajan R, Bulusu L, Adelstein AM, Shukla V. Patterns of mortality among migrants to England and Wales from the Indian subcontinent. BMJ. 1984;289:1185
  121. Office of Population Censuses and Surveys. Mortality and geography. A review in the mid 80s. The registrar-general’s decennial supplement for England and Wales. Series DS 209. London: HMSO, 1990
  122. McKeigue PM, Marmot MG, Adelstein AM, et al.  Diet and risk factors for coronary heart disease in Asians in northwest London. Lancet. 1985;ii:1086
  123. McKeigue PM, Shah B, Marmot MG. Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians. Lancet. 1991;337:382
  124. Yorek M, Leeney E, Dunlop J, Ginsberg B. Effect of fatty acid composition on insulin and IGF-I binding in retinoblastoma cells. Invest Ophthalmol Vis Sci. 1989;30:2087
  125. Ginsberg BH, Chaterjee P, Yorek M. Increased membrane fluidity is associated with greatest sensitivity to insulin (abstract). Diabetes 1987;36(suppl):51A
  126. Ginsberg BH, Jabour J, Spector AA. Effect of alterations in membrane lipid unsaturation on the properties of the insulin receptor of Ehrlich ascites cells. Biochim Biophys Acta. 1982;690:157
  127. Grunfeld C, Baird KL, Kahn CR. Maintenance of 3T3-L1 cells in culture media containing saturated fatty acids decreases insulin binding and insulin action. Biochem Biophys Res Commun. 1981;103:219
  128. Hagre T-A. Effects of unsaturated fatty acids on cell membrane functions. Scand J Clin Lab Invest. 1988;48:381
  129. Storlien LH, Jenkins AB, Chisholm DJ, et al.  Influence of dietary fat composition on development of insulin resistance in rats (relationship to muscle triglycerides and ω-3 fatty acids in muscle phospholipid). Diabetes. 1991;40:280
  130. Pelikanova T, Kohout M, Valek J, Base J, Kazdova L. Insulin secretion and insulin action related to the serum phospholipid fatty acid pattern in healthy men. Metabolism. 1989;38:188
  131. Das UN, Vijaykumar K, Ramesh G. Essential fatty acid metabolism in South Indians. Prostaglandins Leukot Essent Fatty Acids. 1994;50:253
  132. Huang YS, Das UN, Horrobin DF. Effect of dexamethasone on the distribution of essential fatty acids in plasma and liver phospholipids. IRCS Med Sci. 1986;14:180
  133. Tilvis RS, Miettinen TA. Fatty acid composition of serum lipids erythrocytes and platelets in insulin dependent diabetes. J Clin Endocrinol Metab. 1985;61:741
  134. Tilvis RS, Helve E, Miettinen TA. Improvement of diabetic control by continuous subcutaneous insulin infusion therapy changes fatty acid composition of serum lipids and erythrocytes in type 1 (insulin dependent) diabetes. Diabetologia. 1986;29:690
  135. Borkman M, Storlien LH, Pan DA, et al.  The relation between insulin sensitivity and the fatty acid composition of skeletal muscle phospholipids. N Engl J Med. 1993;328:238
  136. Mohan IK, Das UN. Oxidant stress anti-oxidants and nitric oxide in non-insulin dependent diabetes mellitus. Med Sci Res. 1997;25:55
  137. Blanchet F, Gauchy C, Perez S, Glowinski J, Kemel ML. Role of arachidonic acid in the regulation of the NMDA-evoked release of acetylcholine in striatal compartments. Synapse. 1999;31:140
  138. Takeuchi T, Okuda M, Yagasaki O. The differential contribution of endogenous prostaglandins to the release of acetylcholine from the myenteric plexus of the guinea-pig ileum. Br J Pharmacol. 1991;102:381
  139. Lawson DL, Mehta JL, Saldeen K, Mehta P, Saldeen TG. Omega-3 polyunsaturated fatty acids augment endothelium-dependent vasorelaxation by enhanced release of EDRF and vasodilator prostaglandins. Eicosanoids. 1991;4:217

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Nutrition
Volume 17, Issue 4 , Pages 337-346 , April 2001

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