Nutrition
Volume 17, Issue 4 , Pages 300-304 , April 2001

Persistent inflammation and immune activation contribute to cholestasis in patients receiving home parenteral nutrition

  • Jean-Marie Reimund, MD, PhD

      Affiliations

    • Service d’Hépato-Gastroentérologie et d’Assistance Nutritive, Centre Agréé de Nutrition Parentérale à Domicile, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, Strasbourg, France
    • Laboratoire de Pharmacologie et Physico-chimie Cellulaire et Moléculaire, UMR CNRS 7034, UFR de Sciences Pharmaceutiques,Illkirch, France
    • Corresponding Author InformationCorrespondence to: Jean-Marie Reimund, MD, PhD, Service d’Hépato-Gastroentérologie et d’Assistance Nutritive, Centre Agréé de Nutrition Parentérale à Domicile, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, Avenue Molière, 67098 Strasbourg Cedex, France
  • ,
  • Bernard Duclos, MD

      Affiliations

    • Service d’Hépato-Gastroentérologie et d’Assistance Nutritive, Centre Agréé de Nutrition Parentérale à Domicile, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, Strasbourg, France
    • Unité INSERM U381, Strasbourg, France
  • ,
  • Yves Arondel, MD

      Affiliations

    • Service d’Hépato-Gastroentérologie et d’Assistance Nutritive, Centre Agréé de Nutrition Parentérale à Domicile, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, Strasbourg, France
  • ,
  • René Baumann, MD

      Affiliations

    • Service d’Hépato-Gastroentérologie et d’Assistance Nutritive, Centre Agréé de Nutrition Parentérale à Domicile, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, Strasbourg, France

,Accepted 9 November 2000.

References 

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  3. Whitington PF. Cholestasis associated with total parenteral nutrition in infants. Hepatology. 1985;5:693
  4. Baker AL, Rosenberg IH. Hepatic complications of total parenteral nutrition. Am J Med. 1987;82:489
  5. Sax HC, Bower RH. Hepatic complications of total parenteral nutrition. JPEN. 1988;12:615
  6. Clarke PJ, Ball MJ, Kettlewell MGW. Liver function tests in patients receiving parenteral nutrition. JPEN. 1991;15:54
  7. Bowyer B, Fleming C, Ludwig J, et al.  Does long term home parenteral nutrition in adult patients cause chronic liver disease?. JPEN. 1985;9:11
  8. Quigley EMM, Marsh MN, Shaffer JL, et al.  Hepatobiliary complications of total parenteral nutrition. Gastroenterology. 1993;104:286
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  11. Nanji AA, Anderson FH. Sensitivity and specificity of liver function tests in the detection of parenteral nutrition-associated cholestasis. JPEN. 1985;9:307
  12. Campos AC, Oler A, Meguid MM, Chen T-Y. Liver biochemical and histological changes with graded amounts of total parenteral nutrition. Arch Surg. 1990;125:447
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  14. Fromenty B, Pessayre D. Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity. Pharmacol Ther. 1995;67:101
  15. Rashid A, Koteish AK, Cortez-Pinto H, et al.  Subcellular localization of uncoupling receptor (UCP)2 and evidence for increased UCP2 expression in nonalcoholic steatohepatitis (abstract). Hepatology. 1999;30:980
  16. Leclercq IA, Field J, Bell DR, Farrell GC, Robertson GR. Involvment of CYP2E1 and CYP4A in the pathogenesis of experimental nonalcoholic steatohepatitis (insights from studies in CYP2E1 knockout mice (abstract)). Hepatology. 1999;30:1055
  17. Messing B, Colombel JF, Heresbach D, Chazouillères O, Galian A. Chronic cholestasis and macronutrient excess in patients treated with prolonged parenteral nutrition. Nutrition. 1992;8:30
  18. Cavicchi M, Beau P, Crenn P, Degott C, Messing B. Prevalence of liver disease in patients receiving home parenteral nutrition for permanent intestinal failure. Ann Intern Med. 2000;132:525
  19. Raina N, Cameron RG, Jeejeebhoy KN. Gastrointestinal, hepatic, and metabolic effects of enteral and parenteral nutrition in rats infused with tumor necrosis factor. JPEN. 1997;21:7
  20. Heyman M, Darmon N, Dupont C, et al.  Mononuclear cells from infants allergic to cow’s milk secrete tumor necrosis factor α, altering intestinal function. Gastroenterology. 1994;106:1514
  21. Keith ME, Norwich KH, Jeejeebhoy KN. Nutritional support affects the distribution and organ uptake of cachectin/tumor necrosis factor in rats. JPEN. 1995;19:341

PII: S0899-9007(00)00583-9

Nutrition
Volume 17, Issue 4 , Pages 300-304 , April 2001